Rle Finals
Rle Finals
Rle Finals
ABORTION
Questions:
1. What is the definition of abortion?
Abortion is the termination or the end of pregnancy before fetus is viable at 20 weeks
gestation or when the fetus is delivered at less than 500 grams.
2. Different types of abortion?
There are two types of abortion these are:
1. Spontaneous Abortion
This type of abortion is an ending of pregnancy that is not associated which the use of
interventions made by the mother or any medical practitioner and this type of abortion
occurs naturally. Spontaneous abortion occurs because of:
Abnormal fetal position
Maternal age above 35 years old and below 18 years old
Abnormal embryonic development
Viral infections (ex. Varicella, rubella, Cytomegalovirus)
Immune response
Trauma and accidents
Exposure to teratogenic substances (ex. (T)oxoplasmosis, (O)ther Agents,
(R)ubella (also known as German Measles), (C)ytomegalovirus, and (H)erpes
Simplex.)
Too much sexual activity
Incompetent cervix
There are different types of spontaneous abortions such as:
Threatened
Inevitable
Complete
Incomplete
Missed
Habitual
Septic
2. Induced or Elective Abortion
This type of abortion is done for therapeutic purposes in order to preserve or protect
the health of the mother. The pregnant mother could be induced at roughly about 20
weeks of gestation and this is done in cases such as where the fetus could endanger
the life of the mother such as genetic disease and anomalies.
3. What are the causes and risk factors of abortion?
Miscarriage or abortion goes along with different causes and risk that could affect
maternal health.
There are different factors for miscarriage that parents, fetus or both that could
partake.
Lifestyle factors such as:
Smoking
Drinking of alcohol
Using of illegal drugs
Consuming too much caffeine
The reproductive system of the female consists of two main parts these are the uterus
and the ovaries which produce the woman’s egg cells. A female’s internal productive
organs consist of the vagina, uterus, fallopian tubes, cervix and the ovary. While the
mons pubis, pudendal cleft, labia majora and minora, vulva, Bartholin’s gland and
clitoris.
Uterus
Produces vaginal and uterine secretions
Hosts the developing fetus
Passes the anatomically male sperm through the fallopian tubes
Ovaries
Produces the anatomically female egg cells
Produce and secrete estrogen and progesterone
Ovaries
The ovum producing organs of the internal female reproductive system.
Secretes estrogen and progesterone
Attached to the uterus via ovarian ligament (which runs in the broad ligament)
There are two extremities to the ovary, the tubal extremity and the uterine
extremity.
Endocrine organs and produce hormones that act during the female menstrual
cycle and pregnancy.
Locates in the lateral wall of the pelvis in a region called the ovarian fossa.
Ovaries takes turns releasing the eggs every moth, however if one is absent or
dysfunctional then the other ovary releases egg every month.
Uterus
The body of the uterus is connected to the ovaries via the fallopian tubes, and
opens into the vagina via the cervix.
Two Mullerian ducts: usually form initially in a female fetus, but I humans they
completely fuse into a single uterus during gestation.
Essential in sexual response by directing blood flow to the pelvis and to the
external genitalia, including the ovaries, vagina, labia and the clitoris.
Its function is to accept a fertilized ovum which passes through the utero-tubal
junction from the fallopian tube.
The lining of the uterine cavity is called the endometrium.
Female Duct System
The fallopian tubes, or oviducts, connects the ovaries to the fetus.
The fallopian tube allows passage of the egg from the ovary to the uterus.
The lining of the fallopian tube is ciliated and have several segments, including
the infundibulum, ampullary, isthmus, and interstitial regions.
Interspersed between the ciliated cells are peg cells, which contains apical
granules and produce the tubular fluid that contains nutrients for spermatozoa,
oocytes and zygotes.
Sometimes the embryo implants into the fallopian tube instead of the uterus
creating an ectopic pregnancy.
Vagina
Female reproductive tract that has two primary functions: sexual intercourse and
childbirth
Situated between the cervix of the uterus and the external genitalia, primarily
the vulva
The length of the aroused vagina of a woman of childbearing age is
approximately 6 to 7.5 cm (2.5 to 3 inches) across the interior wall (front) and 9
cm (3.5 inches) long across the posterior wall (rear)
During sexual arousal the vagina expands both length and width
Vaginal lubrication is provided by the Bartholin’s glands near the vaginal opening
and the cervix
Hymen is a membrane of tissue that surrounds or partially covers the external
opening.
Vulva
External genitalia of the female reproductive tract, situated immediately external
to the genital orifice
Rich in nerves that are stimulated during sexual activity and arousal
Contains the opening of the female urethra and thus serves the vital function of
passing urine.
Perineum
Region between the genitals and the anus, including the perineal body and
surrounding structures
Refer to both external and deep structures
An erogenous zone for both males and females
Mammary Glands
An organ in female mammals that produces milk to feed young offspring.
Not associated with female reproductive tract, but develop as secondary sex
characteristics in reproductive-age females.
Basic component are alveoli, hollow cavities, a few millimeters large lined with
milk-secreting cuboidal cells and surrounded by myoepithelial cells
ECTOPIC PREGNANCY
1. What is ectopic pregnancy?
In anormal pregnancy the fertilized egg is attached to the lining of the uterus.
While an ectopic pregnancy or tubal pregnancy occurs when the fertilized egg is
implanted and grows outside the main cavity of the uterus. Ectopic pregnancy
often occurs in the fallopian tube, which carries the eggs from the ovaries to the
uterus. Sometimes, ectopic pregnancy may also occur in areas such as ovary,
and abdominal cavity or the lower part of the uterus which is the cervix.
2. Enumerate the sites of ectopic pregnancy. What is the most common?
1. Fallopian tube – most common
2. Cervix
3. Abdomen
4. Ovaries
3. What are the early signs of ectopic pregnancy. What are the life-threatening
symptoms?
Early signs of ectopic pregnancy:
Kehr’s sign – a severe lower quadrant pain radiating to the shoulders that
causes inflammation.
Pain when urinating
Vaginal bleeding that is slightly dark red
Internal bleeding where the hemorrhage is only on the affected site
Cullen’s sign- internal bleeding that will cause bluish navel
Life threatening symptoms of ectopic pregnancy:
Severe abdominal pain or pelvic pain accompanied by vaginal bleeding- heavy
bleeding inside the abdomen likely occurred
Extreme lightheadedness or fainting
Shoulder pain
External cephalic version – the doctor uses ultrasound imaging and external
massage on the mother’s abdomen to try to turn the baby from a head-up
position (breech) to a head-down position in readiness for childbirth. This
procedure can occasionally (rarely) dislodge the placenta.
4. What are the effects of Placental Abruption on the mother?
Placental abruption is life-threatening to the mother and these complications
includes:
Blood loss.
Blood clotting issues.
Blood transfusion.
Hemorrhage.
Kidney failure.
5. What are the effects of Placental Abruption on the baby?
Placental abruption is life-threatening to the baby and these complications
includes:
Premature birth.
Low birth weight.
Growth problems.
Brain injury from lack of oxygen.
Stillbirth.
6. What are the signs and symptoms of Placental Abruption?
Couvelaire uterus – forming a hard board like uterus
Uterus is enlarged due to concealed bleeding
Painful vaginal bleeding in the 3rd trimester
Sharp-like stabbing pain that radiates in the back
Heavy dark red bleeding
Labor pains (uterine contractions) that do not relax
7. What is the difference between Abruptio placenta and placenta previa?
Abruptio placenta is when the placenta is partially or completely detaches itself
from the uterine wall before the delivery of the fetus. While placenta previa
refers to placenta which is implanted partially or completely over the lower
uterine segment.
8. What diagnostic test is done to confirm Abruptio Placenta?
Abruptio placenta could be diagnosed by conducting a physical examination and
ultrasound.
10. Formulate at least 2 nursing diagnoses.
Fear r/t threat to self and fetus
Acute Pain: abdominal/back r/t premature separation of placenta before
deliver
Acute Pain r/t surgical incision
impaired Tissue integrity: maternal r/t possible uterine rupture
PREGNANCY INDUCED HYPERTENSION
Questions:
Case 4:
Mild pre-eclampsia
Blood pressure 140/90 or systolic pressure elevated 30 mm Hg or diastolic pressure
elevated 15 mm Hg above prepregnancy level; proteinuria of 1–2% on a random
sample; weight gain over 2 lb per wk in second trimester and 1 lb per week in third
trimester; mild edema in upper extremities or face.
Severe pre-eclampsia
Blood pressure of 160/110; proteinuria 3–4% on a random sample and 5 g on a 24-hour
sample; oliguria (500 mL or less in 24 hours or altered renal function tests; elevated
serum creatinine more than 1.2 mg/dL); cerebral or visual disturbances (headache,
blurred vision); pulmonary or cardiac involvement; extensive peripheral edema; hepatic
dysfunction; thrombocytopenia; epigastric pain
Eclampsia
Seizure or coma accompanied by signs and symptoms of pre-eclampsia
HELLP syndrome is a variation of PIH named for the common symptoms that occur:
hemolysis that leads to anemia, elevated liver enzymes that lead to epigastric pain, and
low platelets that lead to abnormal bleeding/clotting and petechial (Guberman,
Greenspon, & Goodwin, 2007).
The syndrome occurs in 4% to 12% of patients with PIH. It is a serious syndrome
because it results in a maternal mortality rate as high as 24% and an infant mortality
rate as high as 35%.
3. What are the contributing factors that lead to the development of this condition?
The cause of PIH is unknown. Some conditions may increase the risk of developing PIH,
including the following:
pre-existing hypertension (high blood pressure)
kidney disease
diabetes
PIH with a previous pregnancy
mother's age younger than 20 or older than 40
multiple fetuses (twins, triplets)
4. What are the significant laboratory findings results presented that confirm the diagnosis?
Through this test we are able to identify that is patient is experiencing PIH.
Her platelet count and Hb is abnormal. Biochemistry results mostly shows abnormal results such
as the urea, bilirubin, bilirubin direct, SGOT, SGPT, LDH.
5. What are the signs and symptoms of PIH and at what age in weeks does it appear?
A serious medical condition that can occur about midway through pregnancy (after 20
weeks). Most common symptoms of high blood pressure in pregnancy. However, each
woman may experience symptoms differently. Symptoms may include:
increased blood pressure
protein in the urine
edema (swelling)
sudden weight gain
visual changes such as blurred or double vision
nausea, vomiting
right-sided upper abdominal pain or pain around the stomach
urinating small amounts
changes in liver or kidney function tests
6. Discuss the pathophysiology of the disease. Make a schematic diagram
7.What are the complication of PIH?
There are other problems that may develop as a result of PIH. Placental abruption (premature
detachment of the placenta from the uterus) may occur in some pregnancies. PIH can also lead
to fetal problems including intrauterine growth restriction (poor fetal growth) and stillbirth. If
untreated, severe PIH may cause dangerous seizures and even death in the mother and fetus.
Because of these risks, it may be necessary for the baby to be delivered early, before 37 weeks
gestation.
HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening
pregnancy complication usually considered to be a variant of preeclampsia. Both conditions
usually occur during the later stages of pregnancy, or soon after childbirth.
HELLP syndrome was named by Dr. Louis Weinstein in 1982 after its characteristics:
Labor induction — also known as inducing labor — is the stimulation of uterine contractions
during pregnancy before labor begins on its own to achieve a vaginal birth. A health care
provider might recommend labor induction for various reasons, primarily when there's concern
for a mother's health or a baby's health. One of the most important factors in predicting the
likelihood of a successful labor induction is how soft and distended your cervix is (cervical
ripening)
The Bishop score is a scale used by medical professionals to assess how ready your cervix is for
labor. Your healthcare provider can use the score to estimate the likelihood of a vaginal birth if
you need to be induced. The higher the score, the more likely you will have a successful
induction.
11. The patient verbalize her feelings “I am worried to loss my baby”. What would be your
response?
Listen actively to the patient and show empathy make sure to share hope to the patient like “I
believe you can get through this and the baby will be safe because we are doing our best to
improve your situation and save you and your baby from harm. I need you to remain clam and
be strong because everything will be fine.”
your pregnancy
overall health and medical history
extent of the disease
your tolerance for specific medications, procedures, or therapies
expectations for the course of the disease
your opinion or preference
The goal of treatment is to prevent the condition from becoming worse and to prevent it from
causing other complications. Treatment for pregnancy-induced hypertension (PIH) may include:
Nurses also have a role in reducing the blood pressure of the patient. These are just simple
interventions but could create a dramatic effect when applied properly.
Assess vital signs, especially blood pressure. An elevated blood pressure of 140/90
mmHg and above would indicate hypertension.
Presence of protein could be determined through urine tests.
Assess patient for the presence of edema on the face, fingers, and upper extremities.
Promote bed rest in a recumbent position to aid in the secretion of sodium.
Promote good nutrition, since the woman has still to continue her usual pregnancy
nutrition.
Provide emotional support to establish a trusting relationship and let the woman voice
out her fears.
14. Identify at least two nursing diagnosis and make a nursing care plan.
POST PARTUM HEMORRHAGE
Postpartum hemorrhage (PPH) is severe bleeding after giving birth. It's a serious and
dangerous condition. PPH usually occurs within 24 hours of childbirth, but it can happen up to
12 weeks postpartum. When the bleeding is caught early and treated quickly, it leads to more
successful outcomes. Postpartum hemorrhage is when the total blood loss is greater than 32
fluid ounces after delivery, regardless of whether it’s a vaginal delivery or a Cesarian section, or
C-section, or when bleeding is severe enough to cause symptoms of too much blood loss or a
significant change in heart rate or blood pressure.
The causes of postpartum hemorrhage are called the four Ts (tone, trauma, tissue and
thrombin). The most common causes of PPH are:
Uterine atony: Uterine atony (or uterine tone) refers to a soft and weak uterus after
delivery. This is when your uterine muscles don’t contract enough to clamp the placental
blood vessels shut. This leads to a steady loss of blood after delivery.
Uterine trauma: Damage to your vagina, cervix, uterus or perineum (area between your
genitals and anus) causes bleeding. Using instruments like forceps or vacuum extraction
during delivery can increase your risk of uterine trauma. Sometimes, a hematoma
(collection of blood) can form in a concealed area and cause bleeding hours or days
after delivery.
Retained placental tissue: This is when the entire placenta doesn't separate from your
uterine wall. It’s usually caused by conditions of the placenta that affect your uterus’s
ability to contract after delivery.
Blood clotting condition (thrombin): If you have a coagulation disorder or pregnancy
condition like eclampsia, it can interfere with your body’s clotting ability. This can make
even a tiny bleed uncontrollable.
3. Who is at risk for postpartum hemorrhage?
Some women are at greater risk for postpartum hemorrhage than others. Conditions that may
increase the risk include:
Placental abruption. This is the early detachment of the placenta from the uterus.
Placenta previa. This is when the placenta covers or is near the opening of the cervix.
Overdistended uterus. This is when the uterus is larger than normal because of too
much amniotic fluid or a large baby.
Multiple-baby pregnancy
High blood pressure disorders of pregnancy
Having many previous births
Prolonged labor
Infection
Obesity
Use of forceps or vacuum-assisted delivery
Being of Asian or Hispanic ethnic background
What are the symptoms of postpartum hemorrhage?
These are the most common symptoms of postpartum hemorrhage:
Uncontrolled bleeding
Decreased blood pressure
Increased heart rate
Decrease in the red blood cell count
Swelling and pain in the vagina and nearby area if bleeding is from a hematoma
4. Can low iron cause postpartum hemorrhage?
Indications for the D&C in the pregnant patient include elective termination of pregnancy, early
pregnancy failure, evacuation of a molar pregnancy, or suspected retention of products of
conception. The pregnant D&C is usually performed with either manual or electric vacuum
aspiration.
A dilation and curettage procedure, also called a D&C, is a surgical procedure in which the
cervix (lower, narrow part of the uterus) is dilated (expanded) so that the uterine lining
(endometrium) can be scraped with a curette (spoon-shaped instrument) to remove abnormal
tissues.
CESAREAN SECTION
Scheduled Cesarean Birth are planned which means there is time for thorough preparation for
the experience throughout the antepartal period.
Emergent Cesarean Birth are done for reasons that arise suddenly in labor, such as placenta
previa, premature separation of placenta, fetal distress or failure to progress
2. What are the following indication or reasons for the need of caesarean section?
Labor fails to progress
Compressed umbilical cord Umbilical cord compression happens when the
umbilical cord, the tube-like structure that connects the placenta to the fetus,
becomes compressed or flattened, restricting the flow of blood, oxygen, and
nutrients to the baby.
Abnormal fetal heart rate
Pregnancy of multiples
Placenta previa (the placenta lies over the cervix)
Placenta accrete (the placenta grows too deeply into the uterine wall)
A fetus that is too big to be born vaginally
A fetus in an unfavorable position (breech or transverse lie)
HIV infection
Active herpes infection
Diabetes
High blood pressure / Incompatible Pelvic outlet…( PELVIMETRY)
3. What are the major risk or complication in caesarean birth?
FOR THE MOTHER
Infection
Blood loss
Blood clots A blood clot, also called a thrombus, is blood that has coagulated
or clotted.
Injury to bowel or bladder
Amniotic fluid embolism can cause potentially life-threatening breathing and
heart issues, as well as uncontrolled bleeding. It is an often-fatal emergency that
requires immediate medical care for both the pregnant person and the baby.
Reaction to anesthesia
Amniotic fluid embolism is a rare but serious condition that occurs when amniotic
fluid — the fluid that surrounds a baby in the uterus during pregnancy — or fetal
material, such as fetal cells, enters the mother's bloodstream.
FOR THE BABY
Altered immune development
Increased likelihood of developing allergies and asthma
Reduced gut microbiome diversity -The gut flora (also referred to as the
microbiome, microbiota, or microflora) make up a world of microorganisms that
populate our gastrointestinal tract. It is estimated there are about 100 trillion of
these microorganisms, called microbes.
4. What are the different type of anesthesia used in caesarean section described and
discuss each procedure.
There are two main types of anesthesia typically used: regional anesthesia, which makes an
area of your body numb, like a spinal block, combined spinal-epidural anesthesia (CSE) or
epidural anesthesia; and general anesthesia, where you go to "sleep" for the surgery.
The regional anesthesias, like an epidural, will block pain sensation in your
abdomen and nearby parts.3 You will be wide awake during the surgery and
aware of everything. You will feel pushing, pulling and tugging, but not pain.
One of the regional anesthesia choices is the most common type of anesthesia
for an elective cesarean section. Additional medications can be given if you are
experiencing nausea, anxiety, etc.
General anesthesia is used when your medical history or an emergency dictates
that regional anesthesia is too risky or not possible.
5. Reason for indwelling catheter insertion before surgery in C- section. What are the
possible complication in prolong Foley catheter insertion?
Kidney damage (usually only with long-term, indwelling catheter use) Urethral injury. Urinary
tract or kidney infections. Bladder cancer (only after long-term indwelling catheter)
6. Explain how important is breast feeding to both mother and the baby and skin to skin
contact soon after delivery of the baby
Weight gain improves because your baby doesn’t use as much energy to regulate body
temperature. Instead, that energy can go toward growing. Improved breastfeeding also
contributes to healthier weight gain. Newborns that have skin-to-skin contact immediately after
birth are twice as likely to breastfeed within the first hour. Mom’s prolactin level rises as a result
—this is a hormone that is critical in maintaining a strong milk supply.
7. When can the mother start having sex again after caesarean section and what should I
be doing for birth control?
Sexual activity after a cesarean delivery, but many women will wait between four and six weeks
before resuming intercourse.
Although you may experience slightly less bleeding with a cesarean section, it will still take
about six weeks for your cervix to close completely. Some women may feel ready to resume
intercourse sooner than others, but you should only have sex again once given the ok by your
obstetrician and when you feel comfortable.
Combined hormonal methods increase the risk of DVT even further. If you have no additional
risk factors for DVT and you are not breastfeeding, you can start using these methods 3 weeks
after childbirth. There is a very small risk that the estrogen in these methods can affect your
milk supply if you are breastfeeding.
8. What is the meaning of postpartum depression and its management? Discuss.
Postpartum depression (PPD) is a complex mix of physical, emotional, and behavioral changes
that happen in some women after giving birth. According to the DSM-5, a manual used to
diagnose mental disorders, PPD is a form of major depression that begins within 4 weeks after
delivery. The diagnosis of postpartum depression is based not only on the length of time
between delivery and onset but on the severity of the depression.
Cesarean section is indicated and the best for the client in the case scenario because the baby’s
cord is possibly wrapping around the baby’s neck and this is great risk for the life of the fetus,
the placenta is transverse and the baby in is breech presentation-footling
10. Formulate 2 nursing diagnosis and nursing intervention post caesarean section.
11. Mrs L. is receiving IV fluids of D5 LRS 1 Li.x 8 hours. Calculate how many gtts. / Min.
and cc. / hour will the patient received. Show formulas.
12. Oxytocin was incorporated to 2nd bottle of IVF. Discuss the rationale of giving oxytocin
to patient postpartum
Antepartum: Induction of labor in pts with medical indication (e.g., at or near term), to
stimulate reinforcement of labor, as adjunct in managing incomplete or inevitable abortion.
Postpartum: To produce uterine contractions during third stage of labor and to control
postpartum bleeding/hemorrhage.
Abortion
Abortion is the expulsion or extraction of an embryo or fetus weighing 500 g or less from its
mother when it is not capable of independent survival (i.e. before the period of viability)
Incidence
• 10–20% of all clinical pregnancies
• 75% abortions occur before the 16th week
• Rates vary with maternal age; also high in women with past miscarriages
Abortion
Spontaneous
o Isolated
Threatened
Inevitable
Incomplete Complete
Missed Septic
o Recurrent
Induced
o MTP
o Illegal
Etiology
• Fetal Factors
• Maternal Factors
Fetal Factors
• Genetic
– 50% of early miscarriage is due to chromosomal abnormalities
– Numerical defects like Trisomy, Polyploidy, Monosomy
– Structural defects like translocation, deletion, inversion
• Multiple Pregnancies
• Degeneration of villi
Maternal Factors
• ENDOCRINE AND METABOLIC FACTORS (10–15%):
– Luteal Phase Defect
– Thyroid abnormalities
– Diabetes mellitus
• Anatomical abnormalities (10–15%)
Cervicouterine factors
– Cervical incompetence & insufficiency
– Congenital malformation of the uterus
– Uterine Fibroid
– Intrauterine adhesions
• Infections (5%)
– Viral: rubella, cytomegalo, HIV,..
– Parasitic: toxoplasma, malaria,..
– Bacterial: ureaplasma, chlamydia,..
• IMMUNOLOGICAL DISORDERS (5–10%)
– Autoimmune disease
– Alloimmune disease
– Antifetal antibodies
• Environmental Factors
– Cigarette smoking
– Alcohol consumption
– Contraceptive agents
• Maternal medical illness
– Cyanotic heart disease
– Hemoglobinopathies
• Unexplained (40-60%)
– In majority, the exact cause is not known.
Threatened Abortion
• Condition in which miscarriage has started but has not progressed to a state from which
recovery is impossible
CLINICAL FEATURES:
• The patient, having amenorrhea, complains of:
(1) Slight bleeding per vagina
(2) Pain: Usually painless; there may be mild backache or dull pain in lower abdomen
• The uterus and cervix feel soft.
• Digital examination reveals closed external os
• Differential diagnosis includes
– cervical ectopy
– polyps or carcinoma
– ectopic pregnancy
– molar pregnancy
Inevitable Abortion
It is the clinical type of abortion where the changes have progressed to a state from
where continuation of pregnancy is impossible.
CLINICAL FEATURES:
• The patient, having the features of threatened miscarriage, presents with
– vaginal bleeding
– Aggravation of colicky pain in the lower abdomen
• Sometimes, the features may develop quickly without prior clinical evidence of threatened
miscarriage
• Internal examination reveals dilated internal os through which the products of conception are
felt
Management
• Management is aimed:
– To accelerate the process of expulsion
– To maintain strict asepsis
• If pregnancy < 12 weeks, suction evacuation is done
• If pregnancy > 12 weeks, expulsion by oxytocin infusion
• General measures:
– Excessive bleeding is controlled by administering methergine 0.2 mg
– Blood loss is corrected by IV fluid therapy and blood transfusion
Incomplete abortion
The process of abortion has already taken place, but the entire products of conception are not
expelled & a part of it is left inside the uterine cavity
Clinical features:
• History of expulsion of a fleshy mass per vaginam;
– Continuation of pain in lower abdomen
– Persistence of vaginal bleeding
• Internal examination reveals
– uterus smaller than the period of amenorrhea
– Open internal os
– varying amount of bleeding
• On examination, the expelled mass is found incomplete Complications:
• The retained products may cause:
(a) bleeding
(b) sepsis or
(c) placental polyp.
MANAGEMENT:
• Evacuation of the retained products of conception (ERCP)
• Early abortion: Dilatation and evacuation under analgesia or general anesthesia is to be done.
• Late abortion: Uterus is evacuated under general anesthesia and the products are removed by
ovum forceps or by blunt curette. In late cases, D&C is to be done to remove the bits of tissues
left behind.
• Prophylactic antibiotics are given; removed materials are subjected to a histological
examination.
• Medical management
- Tab. Misoprostol 200 μg is used vaginally every 4 hours
Complete Abortion
• When the products of conception are completely expelled from the uterus, it is called
complete miscarriage.
Clinical features
• There is history of expulsion of a fleshy mass per vaginam followed by
– Subsidence of abdominal pain
– Vaginal bleeeding becomes trace or absent
• Internal examination reveals:
– Uterus smaller than the period of amenorrhea
– Cervical os is closed
– Bleeding is trace.
• Transvaginal sonography confirms that uterus is empty
Missed Abortion
• The fetus is dead and retained passively inside the uterus for a variable period
• It is diagnosed when there is a fetus with a crown rump length of 5mm without a fetal heart.
CLINICAL FEATURES:
The patient usually presents with features of threatened miscarriage followed by:
– Subsidence of pregnancy symptoms
– Uterus becomes smaller in size
– Cervix feels firm with closed internal os
– Nonaudibility of the fetal heart sound even with Doppler ultrasound
– Immunological test for pregnancy becomes negative
Complications
• Retaining the products for long time can lead to sepsis
• DIC [Disseminated Intravascular Coagulation]
– (very rare) in gestations exceeding 16 weeks
Management Uterus is less than 12 weeks:
• Prostaglandin E1 (Misoprostol) 800 mg is given vaginally and repeated after 24 hours if
needed. Expulsion usually occurs within 48 hours
• Suction evacuation is done when the medical method fails Uterus more than 12 weeks
• 6th or 12th hourly misoprostol tablets given vaginally
• If this fails, extra amniotic instillation of ethacridine lactate is used
• Antibiotics are given
Septic Abortion
• Any abortion associated with clinical evidences of infection of the uterus and its contents
• Most common cause
– Attempt at induced abortion by an untrained person without the use of aseptic precautions
Clinical Grading:
• Grade–I: The infection is localized in the uterus.
• Grade–II: The infection spreads beyond the uterus to the parametrium, tubes and ovaries or
pelvic peritoneum.
• Grade–III: Generalized peritonitis and/or endotoxic shock or jaundice or acute renal failure.
Grade-I is the commonest and is usually associated with spontaneous abortion
Clinical Features
• Fever, abdominal pain and vomiting or diarrhea
• A rising pulse rate of 100–120/min or more is a significant finding than even pyrexia. It
indicates spread of infection beyond the uterus.
• Examination shows abdominal tenderness, guarding, rigidity
• Internal examination reveals:
– offensive purulent vaginal discharge
– tender uterus usually with patulous os or a boggy feel
– Soft cervix with open internal os
Investigations
• CBC
• Serum urea, creatinine, electrolytes
• High vaginal swab
• Blood culture in suspected septicaemia
• Pelvic USG to detect retained products of conception
• X-ray abdomen in suspected bowel injury
• X-ray chest if there is difficulty in respiration
Complications Immediate:
• Hemorrhage
• Injury may to uterus & adjacent structures
• Spread of infection leads to:
– Generalized peritonitis
– Endotoxic shock
—mostly due to E. Coli
– DIC
– Acute renal failure
– Thrombophlebitis.
• All these lead to increased maternal deaths
Management
• Mild cases
– Broad spectrum antibiotics started
– Uterus is evacuated
• Severe Cases
– Vigorous IV infusion with crystalloid
– Oxygen given by nasal catheter
– Broad spectrum antibiotics
– combination of ampicillin, gentamicin, metronidazole is started
– Uterus is evacuated in 4-6 hrs of commencing therapy.
Recurrent Miscarriage/ Pregnancy loss
Recurrent Abortion
• Recurrent miscarriage is defined as a sequence of three or more consecutive spontaneous
abortion
• Seen in ~ 1% of all women
• Risk increases with each successive abortion
• No underlying cause is found for 50% of recurrent pregnancy loss
Etiology FIRST TRIMESTER ABORTION:
• Genetic factors (3–5%):
Parental chromosomal abnormalities
The most common abnormality is a balanced translocation.
This leads to unbalanced translocation in the fetus, causing early miscarriage or a live birth with
congenital malformations
Risk of miscarriage in couples with a balanced translocation is > 25%.
This is the most common cause for 1st trimester loss
Endocrine and Metabolic:
– Poorly controlled diabetic patients
– Presence of thyroid autoantibodies
– Luteal phase defect
– Hypersecretion of luteinizing hormone (e.g. in PCOS).
• Infection:
– Infection in the genital tract - (Transplacental fetal infection)
– Syphilis
• Inherited thrombophilia
– Protein C deficiency, Protein S deficiency, factor V Leiden mutation, prothrombin gene
mutation
• Immunological cause:
Autoimmunity – Antiphospholipid antibody syndrome(15%). – Antiphospholipid antibodies
present in mother produce adverse fetal outcome – Diagnosis by presence of lupus
anticoagulant/IgG/IgM anticardiolipin antibodies Alloimmune factors – Immune response
against paternal antigens in the fetus – This is a result of lack of production of blocking
antibodies by the mother due to failure of recognition of TLX
37. SECOND TRIMESTER MISCARRIAGE: • Anatomic abnormalities - responsible for 10– 15% of
recurrent abortion. • Causes may be (a) Congenital - defects in the mullerian duct fusion (e.g.
unicornuate, bicornuate, septate or double uterus) (b) Acquired - intrauterine adhesions,
uterine fibroids and endometriosis, cervical incompetence