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    Natalie Kuldell February 3rd, 2009: Courtesy of Justin Lo. Used With Permission

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    Natalie Kuldell February 3rd, 2009: Courtesy of Justin Lo. Used With Permission

    Uploaded by

    Shiva
    38 views32 pages

    Original Title

    MIT20_020S09_lec1_wk1_orntn

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    Copyright:

    © All Rights Reserved
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    38 views32 pages

    Natalie Kuldell February 3rd, 2009: Courtesy of Justin Lo. Used With Permission

    Uploaded by

    Shiva

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 32

    Courtesy of Justin Lo. Used with permission.

    Natalie Kuldell

    February 3rd, 2009


    2020: Futurists
    Freeman Dyson writes:

    "Biotechnology will become as domesticated as computer


    games and children and housewives will create their new
    animal and plant species at home.”

    Photo of Freeman Dyson

    removed due to copyright restrictions.

    Quack? Genius?
    2020: Futurists
    Freeman Dyson writes:

    "Biotechnology will become as domesticated as computer


    games and children and housewives will create their new
    animal and plant species at home.

    Photo of Freeman Dyson


    removed due to copyright restrictions.

    Quack? Genius?
    MIT Human Ecology Design team

    Courtesy of Mitchell Joachim. Used with permission. See http://www.archinode.com/bienal.html.


    2020: Historians

    Image removed due to copyright restrictions.

    Cover of Omni Magazine, Feburary 1980.

    See http://www.physics.emory.edu/~weeks/sea/omni/800204.htm

    “a sophisticated
    computer at your
    fingertips” Image removed due to copyright restrictions.
    Advertisement from same Omni Magazine issue (1980)
    •20 lb for the Hewlett-Packard HP-85 "personal-professional" computer.
    See http://oldcomputers.net/ads/80s/hp-85.jpg

    •16K RAM
    •Built in thermal
    printer
    •Operating system
    and BASIC language
    in ROM
    “a scientist clad in white
    spools threads of DNA onto a
    glass rod. He is about to treat
    it with enzymes, then insert it
    into E. coli, endowing the
    microbe with powers nature
    never gave it.”

    Image removed due to copyright restrictions.


    Page image from McAuliffe, K., and S. McAuliffe. "The Gene Trust." Omni Magazine, February, 1980.
    What’s new: Application of

    engineering principles to biology


    Courtesy of Vincent Rouilly. Used with permission.


    Postcards & snapshots so far

    •genome re-

    engineering

    Images removed due to copyright restrictions.

    See Chan, L. Y., S. Kosuri, and D. Endy. "Refactoring bacteriophage T7."

    Mol Syst Biol 1 (2005): 0018. PMCID: PMC1681472.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681472/

    Postcards & snapshots so far


    •genome re-
    engineering

    Science 319, no. 5867 (Feb 29, 2008): 1215-20.

    Postcards & snapshots so far


    •genome re-
    engineering

    Science 310, no. 5475 (October 7, 2005): 77-80.


    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory

    Courtesy of the authors. License: Creative Commons attribution.


    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic
    engineering
    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic
    engineering
    •circuit
    engineering
    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic
    engineering
    •circuit
    engineering Source: Nature Biotechnology 21 (2003): 796-802.
    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic
    engineering
    •circuit
    engineering
    •system
    engineering

    Courtesy of Christopher A. Voigt. Used with permission.


    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic Image removed due to copyright restrictions.��
    engineering See: http://www.technologyreview.com/tr35/Profile.aspx?TRID=601

    •circuit
    engineering
    •system
    engineering
    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic
    engineering
    •circuit
    engineering
    •system
    engineering
    •biomaterials

    engineering
    Courtesy of Paul W. K. Rothemund. Used with permission.

    Postcards & snapshots so far

    •genome re-

    engineering

    •DNA based
    memory
    •logic
    engineering
    •circuit
    engineering
    •system
    engineering Courtesy of the League of Imaginary Scientists. Used with permission.

    •biomaterials

    engineering

    What you’ll work on…


    1. design a plausible and compelling synthetic biological system


    2. develop a detailed design plan and construction roadmap

    3. evaluate ownership, commercial, ethical aspects of the project


    Courtesy of Justin Lo. Used with permission.


    What you’ll learn (I think)…

    Tuesdays/Thursdays

    • Start with challenge/puzzle/activity


    • Follow-up with group discussion
    • Occasional homework
    How can biology be made easier to engineer?

    What are the consequences of success?

    How has nature solved physical challenges?

    In what ways does nature innovate?


    Wednesdays
    2-5
    Wednesdays
    2-5
    3 ideas
    presentation
    Wednesdays
    2-5

    Tech spec
    review
    Project
    • 3 ideas presentation

    • Tech spec review


    • Final presentation
    60%, team grades
    Personal Design Portfolio
    Project 25%, individual grades
    • 3 ideas presentation
    Project Development Ntbk
    • Tech spec review
    10%, team grades
    • Final presentation
    Instructor Leverage
    60%, team grades
    5%, individual grades
    any ???s

    Let’s get building!!!


    the end

    MIT OpenCourseWare
    http://ocw.mit.edu

    20.020 Introduction to Biological Engineering Design


    Spring 2009

    For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms.

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