Scribd Logo
Upload

Welcome to Scribd!

  • 89 views

    Herpetiform Pemphigus: Courtesy, Ronald P Rapini, MD

    Uploaded by

    Cristian Quito
    1) Pemphigus foliaceus is a blistering skin disease characterized by multiple erosions and fragile vesicles that rupture easily, leaving scale-crust on the skin surface. Common sites of involvement are the trunk. 2) Herpetiform pemphigus is a variant characterized by erythematous urticarial plaques and tense vesicles in a herpetiform pattern, with minimal acantholysis histologically. It is caused by autoantibodies against desmoglein 1 and 3. 3) Pemphigus erythematosus presents with erythematous plaques and scale-crust in seborrheic areas like the face. Some

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Herpetiform Pemphigus: Courtesy, Ronald P Rapini, MD

    Uploaded by

    Cristian Quito
    89 views1 page
    1) Pemphigus foliaceus is a blistering skin disease characterized by multiple erosions and fragile vesicles that rupture easily, leaving scale-crust on the skin surface. Common sites of involvement are the trunk. 2) Herpetiform pemphigus is a variant characterized by erythematous urticarial plaques and tense vesicles in a herpetiform pattern, with minimal acantholysis histologically. It is caused by autoantibodies against desmoglein 1 and 3. 3) Pemphigus erythematosus presents with erythematous plaques and scale-crust in seborrheic areas like the face. Some

    Original Title

    Untitled3.pdf

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    1) Pemphigus foliaceus is a blistering skin disease characterized by multiple erosions and fragile vesicles that rupture easily, leaving scale-crust on the skin surface. Common sites of involvement are the trunk. 2) Herpetiform pemphigus is a variant characterized by erythematous urticarial plaques and tense vesicles in a herpetiform pattern, with minimal acantholysis histologically. It is caused by autoantibodies against desmoglein 1 and 3. 3) Pemphigus erythematosus presents with erythematous plaques and scale-crust in seborrheic areas like the face. Some

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    89 views1 page

    Herpetiform Pemphigus: Courtesy, Ronald P Rapini, MD

    Uploaded by

    Cristian Quito
    1) Pemphigus foliaceus is a blistering skin disease characterized by multiple erosions and fragile vesicles that rupture easily, leaving scale-crust on the skin surface. Common sites of involvement are the trunk. 2) Herpetiform pemphigus is a variant characterized by erythematous urticarial plaques and tense vesicles in a herpetiform pattern, with minimal acantholysis histologically. It is caused by autoantibodies against desmoglein 1 and 3. 3) Pemphigus erythematosus presents with erythematous plaques and scale-crust in seborrheic areas like the face. Some

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    CHAPTER

    29

    Pemphigus
    A B

    C D

    Fig. 29.8 Pemphigus foliaceus. A,B Multiple erosions arising on an erythematous base as well as the characteristic scale-crust; the latter can vary in thickness. A
     

    common site of involvement is the trunk. C As the disease progresses, the lesions become confluent, but because the vesicles are fragile and rupture easily, only
    erosions with scale-crust are observed. D The scales have been likened to cornflakes.

    Herpetiform Pemphigus
    Most patients with herpetiform pemphigus have a clinical variant of
    pemphigus foliaceus and the remainder may have a variant of pem-
    phigus vulgaris. This disorder is characterized by: (1) erythematous
    urticarial plaques and tense vesicles that present in a herpetiform
    arrangement; (2) eosinophilic spongiosis and subcorneal pustules
    with minimal or no apparent acantholysis histologically; and (3) IgG
    autoantibodies directed against the cell surfaces of keratinocytes46.
    The target antigen is Dsg1 in most cases and Dsg3 in the remain-
    der47. Some patients with herpetiform pemphigus will have fea-
    tures of pemphigus foliaceus or vulgaris during the course of their
    disease, and some patients will evolve into having pemphigus folia-
    ceus or vulgaris. It is assumed that the pathogenic blister-inducing
    activity of the IgG autoantibodies in herpetiform pemphigus might
    be weaker than that seen in classic forms of pemphigus. Although
    often clinically less severe than pemphigus vulgaris, the course may
    Fig. 29.9 Pemphigus erythematosus. Erythematous plaques with scale-crust
     
    be more chronic48.
    and erosions on the nose and malar area of the face. Courtesy, Ronald P Rapini, MD.
    Drug-Induced Pemphigus
    appear in the malar region of the face (Fig. 29.9) and in other “seb- There are sporadic cases of pemphigus associated with the use of drugs,
    orrheic” areas. Originally, the term “pemphigus erythematosus” was in particular penicillamine and captopril49. In patients receiving penicil-
    introduced to describe patients with immunologic features of both lamine, pemphigus foliaceus is seen more commonly than pemphigus
    lupus erythematosus (LE) and pemphigus, i.e. in vivo IgG and C3 vulgaris, with a ratio of approximately 4 : 1. Although most patients
    deposition on cell surfaces of keratinocytes as well as the basement with drug-induced pemphigus are shown to have autoantibodies against
    membrane zone, in addition to circulating antinuclear antibodies45. the same molecules involved in sporadic pemphigus, evidence suggests
    However, only a few patients have been reported to actually have the that some drugs may induce acantholysis without the production of 501
    two diseases concurrently. antibodies. Both penicillamine and captopril contain sulfhydryl groups

    You might also like