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Bleomycin A5 (hydrochloride) Revision: 11/12/2016

according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008

Section 1. Identification of the Substance/Mixture and of the Company/Undertaking

1.1 Product Code: 19692
Product Name: Bleomycin A5 (hydrochloride)
Synonyms: N1-[3-[(4-aminobutyl)amino]propyl]-bleomycinamide, hydrochloride; Bleomycin A5 Hydrochloride
Salt; Pingyangmycin hydrochloride;

1.2 Relevant identified uses of the substance or mixture and uses advised against:
Relevant identified uses: For research use only, not for human or veterinary use.

1.3 Details of the Supplier of the Safety Data Sheet:

Company Name: Cayman Chemical Company

1180 E. Ellsworth Rd.
Ann Arbor, MI 48108
Web site address: www.caymanchem.com
Information: Cayman Chemical Company +1 (734)971-3335
1.4 Emergency telephone number:
Emergency Contact: CHEMTREC Within USA and Canada: +1 (800)424-9300
CHEMTREC Outside USA and Canada: +1 (703)527-3887

Section 2. Hazards Identification

2.1 Classification of the Substance or Mixture:
Acute Toxicity: Inhalation, Category 4
Acute Toxicity: Oral, Category 4
Acute Toxicity: Skin, Category 4
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Carcinogenicity, Category 2
Specific Target Organ Toxicity (single exposure), Category 3
2.2 Label Elements:

GHS Signal Word: Warning

GHS Hazard Phrases:
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H351: Suspected of causing cancer.

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GHS Precaution Phrases:

P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P261: Avoid breathing {dust/fume/gas/mist/vapors/spray}.
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
GHS Response Phrases:
P301+312: IF SWALLOWED: P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
P308+313: IF exposed or concerned: Get medical attention/advice.
P321: Specific treatment {see ... on this label}.
P330: Rinse mouth.
P332+313: If skin irritation occurs, get medical advice/attention.
P337+313: If eye irritation persists, get medical advice/attention.
P362+364: Take off contaminated clothing and wash it before reuse.
GHS Storage and Disposal Phrases:
Please refer to Section 7 for Storage and Section 13 for Disposal information.
2.3 Adverse Human Health Causes serious eye irritation.
Effects and Symptoms: Causes skin irritation.
Harmful if inhaled, swallowed, or in contact with skin.
Material may be irritating to the mucous membranes and upper respiratory tract.
May cause eye, skin, or respiratory system irritation.
Suspected of causing cancer.
To the best of our knowledge, the toxicological properties have not been thoroughly investigated.

Section 3. Composition/Information on Ingredients

CAS # / Hazardous Components (Chemical Name)/ Concentration EC No./ GHS Classification
RTECS # REACH Registration No. EC Index No.
55658-47-4 Bleomycin A5 (hydrochloride) 100.0 % NA Acute Tox.(O) 4: H302
EC5990700 NA Acute Tox.(D) 4: H312
Acute Tox.(I) 4: H332
Skin Corr. 2: H315
Eye Damage 2A: H319
STOT (SE) 3: H335 H336
Carcinogen 2: H351

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Section 4. First Aid Measures

4.1 Description of First Aid
Measures:
In Case of Inhalation: Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel.
Get immediate medical attention.
In Case of Skin Contact: Immediately wash skin with soap and plenty of water for at least 15 minutes. Remove contaminated
clothing. Get medical attention if symptoms occur. Wash clothing before reuse.
In Case of Eye Contact: Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Have eyes examined
and tested by medical personnel.
In Case of Ingestion: Wash out mouth with water provided person is conscious. Never give anything by mouth to an
unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by
medical personnel.

Section 5. Fire Fighting Measures

5.1 Suitable Extinguishing Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.
Media: Use water spray to cool fire-exposed containers.
Unsuitable Extinguishing A solid water stream may be inefficient.
Media:
5.2 Flammable Properties andNo data available.
Hazards:
No data available.
Flash Pt: No data.
Explosive Limits: LEL: No data. UEL: No data.
Autoignition Pt: No data.
5.3 Fire Fighting Instructions: As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved or
equivalent), and full protective gear to prevent contact with skin and eyes.

Section 6. Accidental Release Measures

6.1 Protective Precautions, Avoid raising and breathing dust, and provide adequate ventilation.
Protective Equipment and As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or respirator,
Emergency Procedures: and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves).
6.2 Environmental Take steps to avoid release into the environment, if safe to do so.
Precautions:
6.3 Methods and Material For Contain spill and collect, as appropriate.
Containment and Cleaning Transfer to a chemical waste container for disposal in accordance with local regulations.
Up:

Section 7. Handling and Storage

7.1 Precautions To Be Taken Avoid breathing dust/fume/gas/mist/vapours/spray.
in Handling: Avoid prolonged or repeated exposure.
7.2 Precautions To Be Taken Keep container tightly closed.
in Storing: Store in accordance with information listed on the product insert.

Section 8. Exposure Controls/Personal Protection

8.1 Exposure Parameters:

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8.2 Exposure Controls:

8.2.1 Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne
(Ventilation etc.): levels below recommended exposure limits.
8.2.2 Personal protection equipment:
Eye Protection: Safety glasses
Protective Gloves: Compatible chemical-resistant gloves
Other Protective Clothing: Lab coat
Respiratory Equipment NIOSH approved respirator, as conditions warrant.
(Specify Type):
Work/Hygienic/Maintenan Do not take internally.
ce Practices: Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower.
Wash thoroughly after handling.
No data available.

Section 9. Physical and Chemical Properties

9.1 Information on Basic Physical and Chemical Properties
Physical States: [ ] Gas [ ] Liquid [ X ] Solid
Appearance and Odor: A powder
pH: No data.
Melting Point: No data.
Boiling Point: No data.
Flash Pt: No data.
Evaporation Rate: No data.
Flammability (solid, gas): No data available.
Explosive Limits: LEL: No data. UEL: No data.
Vapor Pressure (vs. Air or mm No data.
Hg):
Vapor Density (vs. Air = 1): No data.
Specific Gravity (Water = 1): No data.
Solubility in Water: No data.
Solubility Notes: Soluble in: water;
Octanol/Water Partition No data.
Coefficient:
Autoignition Pt: No data.
Decomposition Temperature: No data.
Viscosity: No data.
9.2 Other Information
Percent Volatile: No data.
Molecular Formula & Weight: C57H89N19O21S2 • XHCl 1477.0

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Section 10. Stability and Reactivity

10.1 Reactivity: No data available.
10.2 Stability: Unstable [ ] Stable [ X ]
10.3 Stability Note(s): Stable if stored in accordance with information listed on the product insert.
Polymerization: Will occur [ ] Will not occur [ X ]
10.4 Conditions To Avoid: No data available.
10.5 Incompatibility - Materials strong oxidizing agents
To Avoid:
10.6 Hazardous carbon dioxide
Decomposition or carbon monoxide
Byproducts: hydrogen sulfide gas
nitrogen oxides
phosgene

Section 11. Toxicological Information

11.1 Information on The toxicological effects of this product have not been thoroughly studied.
Toxicological Effects: Bleomycin A5 (hydrochloride) - Toxicity Data: Intraperitoneal LD50 (rat): 117 mg/kg; Oral LD50
(mouse): 800 mg/kg; Intraperitoneal LD50 (mouse): 66 mg/kg; Subcutaneous LD50 (mouse): 67
mg/kg;
Chronic Toxicological Bleomycin A5 (hydrochloride) - Investigated as a drug.
Effects: Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.
See actual entry in RTECS for complete information.
Bleomycin A5 (hydrochloride) RTECS Number: EC5990700

CAS # Hazardous Components (Chemical Name) NTP IARC ACGIH OSHA

55658-47-4 Bleomycin A5 (hydrochloride) n.a. n.a. n.a. n.a.

Section 12. Ecological Information

12.1 Toxicity: Avoid release into the environment.
Runoff from fire control or dilution water may cause pollution.
12.2 Persistence and No data available.
Degradability:
12.3 Bioaccumulative No data available.
Potential:
12.4 Mobility in Soil: No data available.
12.5 Results of PBT and vPvB No data available.
assessment:
12.6 Other adverse effects: No data available.

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Section 13. Disposal Considerations

13.1 Waste Disposal Method: Dispose in accordance with local, state, and federal regulations.

Section 14. Transport Information

14.1 LAND TRANSPORT (US DOT):
DOT Proper Shipping Name: Not dangerous goods.
DOT Hazard Class:
UN/NA Number:
14.1 LAND TRANSPORT (European ADR/RID):
ADR/RID Shipping Name: Not dangerous goods.
UN Number:
Hazard Class:
14.3 AIR TRANSPORT (ICAO/IATA):
ICAO/IATA Shipping Name: Not dangerous goods.
Additional Transport Transport in accordance with local, state, and federal regulations.
Information:

Section 15. Regulatory Information

EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists
CAS # Hazardous Components (Chemical Name) S. 302 (EHS) S. 304 RQ S. 313 (TRI)
55658-47-4 Bleomycin A5 (hydrochloride) No No No

CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists

55658-47-4 Bleomycin A5 (hydrochloride) CAA HAP,ODC: No; CWA NPDES: No; TSCA: No; CA
PROP.65: No

Regulatory Information This SDS was prepared in accordance with 29 CFR 1910.1200 and Regulation (EC)
Statement: No.1272/2008.

Section 16. Other Information

Revision Date: 11/12/2016
Additional Information About No data available.
This Product:
Company Policy or Disclaimer: DISCLAIMER: This information is believed to be accurate and represents the best information
currently available to us. However, we make no warranty of merchantability or any other warranty,
express or implied, with respect to such information, and we assume no liability resulting from its
use. Users should make their own investigations to determine the suitability of the information for
their particular purposes.

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