Drug Name Action Indication Contraindication Drug Interaction Adverse Effect Nursing Responsibilities

Generic Name: Amlodipine Known Increased metabolism Assessment

Amlodine relaxes Angina hypersensitivity to with rifampin. Reduced CNS: Dizziness, light-
peripheral and dihydropyridines hypotensive effect with headedness, History: Allergy to
Brand Name: coronary Hypertension calcium. Potentiates effects of headache,asthenia, fatigue, amlodipine, impaired
Norvasc vascular Special Precaution thiazide diuretics and ACE lethargy hepatic or renal function,
smooth Impaired liver or inhibitors. Avoid combination sick sinus
Dosage: muscle. It renal function, with β-blockers in patients CV:Peripheral edema,arrhyt syndrome, heart block,
Amlodipine 10mg produces CHF, sick-sinus with markedly impaired left hmias lactation, CHF
1-0-0 coronary syndrome, severe ventricular function. May
1-0-1 vasodilation ventricular increase serum levels of Dermatologic:Flushing,rash Physical: Skin lesions,
by inhibiting dysfunction, CYP1A2 substrates e.g. color, edema; P, BP,
Date Ordered: the entry of Ca hypertrophic aminophylline, fluvoxamine, GI:Nausea, abdominal baseline ECG, peripheral
09-18-10 ions into the cardiomyopathy, ropinirole. CYP3A4 inhibitors discomfor perfusion,
09-28-10 voltage- severe aortic (e.g. clarithromycin, auscultation; R,
sensitive stenosis doxycycline, isoniazid, adventitious sounds; liver
Pregnancy Category channels of the nicardipine) may increase the evaluation, GI normal
C vascular effects of amlodipine. output; liver and
smooth muscle Additive BP-lowering effects renal function tests,
Drug classes and when used with sildenafil, urinalysis
Calcium channel- myocardium tadalafil or vardenafil
blocker during Interventions
Antianginal drug depolarisation.
Antihypertensive It also Monitor patient carefully
increases (BP, cardiac rhythm, and
Absorption: Well myocardial output) while adjusting
absorbed from the GI O2delivery in drug to
tract (oral); peak patients with therapeutic dose; use
plasma vasospastic special caution if patient
concentrations after angina. has CHF.
6-12 hr.
Distribution: Protein Monitor BP very
-binding: 97.5%. carefully if patient is also
Metabolism: Hepatic on nitrates.
: Extensive.
Excretion: Via urine Monitor cardiac rhythm
regularly during
stabilization of dosage
and periodically
during long-term therapy.

Administer drug without

regard to meals.

Teaching points

Take with meals if upset

stomach occurs.

These side effects may

occur: Nausea, vomiting
(eat small, frequent
meals);
headache (adjust lighting,
noise, and temperature;
medication may be
ordered).

Report irregular
heartbeat, shortness of
breath, swelling of the
hands or feet,
pronounced dizziness,
constipation