Week As C-Shaped Rolls in A Stack, Separated By: Clefts Pharyngeal Pouches

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During embryological development, the pharyngeal arches appear in the fourth


week as c-shaped rolls in a stack, separated by clefts. There are initially six arches,
but the fifth arch regresses before development is complete. Pharyngeal pouches are
developed from the endoderm and they open towards the pharyngeal clefts.

. Four out of the five facial swellings derive from the pharyngeal arches. These
include the bilateral maxillary and mandibular processes and exclude the singular
frontonasal prominence.

· pharyngeal arches are paired structures associated with the pharynx that contribute
greatly to the formation of the face, jaw, ear, and neck

· the 1st pharyngeal arch appears at about the beginning of the 4th week and others
are added more caudally later such that there are ultimately 5 arches by the end of the
4th week; the 5th arch fails to form, so the arches are numbered 1, 2, 3, 4, and 6.

· the entire apparatus consists of paired pharyngeal arches, pharyngeal pouches,


pharyngeal clefts (or grooves), and pharyngeal membranes (see diagram).

 each pharyngeal arch consists of a core of somatic mesoderm and neural crest
mesenchyme
o somatic mesoderm contributes to the arch artery (i.e. aortic arches 1-6)
as well as skeletal muscle tissue in each arch
o neural crest mesenchyme develops into bone, cartilage, and/or
connective tissue in each arch.

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