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    Thalassemia

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    Jobelle Fernandez-Santos
    Family history of Thalassemia is associated with mutations in chromosomes 16 or 11 that result in reduced alpha or beta globin synthesis, respectively, with excess of the other chain. This causes precipitation in bone marrow erythroid precursors, premature cell death, hemolysis, and anemia requiring blood transfusions. Symptoms include pallor, fatigue, dizziness, and others due to inadequate oxygen carrying capacity.

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    Thalassemia

    Uploaded by

    Jobelle Fernandez-Santos
    182 views1 page
    Family history of Thalassemia is associated with mutations in chromosomes 16 or 11 that result in reduced alpha or beta globin synthesis, respectively, with excess of the other chain. This causes precipitation in bone marrow erythroid precursors, premature cell death, hemolysis, and anemia requiring blood transfusions. Symptoms include pallor, fatigue, dizziness, and others due to inadequate oxygen carrying capacity.

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    pathophysiology of thalassemia

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    Family history of Thalassemia is associated with mutations in chromosomes 16 or 11 that result in reduced alpha or beta globin synthesis, respectively, with excess of the other chain. This causes precipitation in bone marrow erythroid precursors, premature cell death, hemolysis, and anemia requiring blood transfusions. Symptoms include pallor, fatigue, dizziness, and others due to inadequate oxygen carrying capacity.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    182 views1 page

    Thalassemia

    Uploaded by

    Jobelle Fernandez-Santos
    Family history of Thalassemia is associated with mutations in chromosomes 16 or 11 that result in reduced alpha or beta globin synthesis, respectively, with excess of the other chain. This causes precipitation in bone marrow erythroid precursors, premature cell death, hemolysis, and anemia requiring blood transfusions. Symptoms include pallor, fatigue, dizziness, and others due to inadequate oxygen carrying capacity.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Family history of Thalassemia

    Southeast Asian decent

    Mutation in chromosome 16 or 11

    Reduced alpha globin synthesis


    Reduced beta globin synthesis With excess beta globin chain
    With excess alpha globin chain

    Precipitation in erythroid
    Membrane damage to precursor within bone marrow
    peripheral erythrocytes

    Premature death of erythroid


    precursors
    Hemolysis

    Ineffective erythropoiesis

    Anemia

    Blood transfusion
    Inadequate Pallor
    Infectious agent oxyhemoglobin

    Antibiotic
    Activity
    Inadequate intolerance
    Overcome oxygen carrying Weakness
    protective barriers capacity
    or the resp system

    Cytokines & Tissue hypoxia Dizziness


    (Cerebral)
    Fever inflammatory
    Cough mediators

    Fluid accumulation Hypoxic Tachycardia


    in the alveoli w/ sensors Tachypnea
    Crackles impaired gas
    exchange

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