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    Symptoms: Cyanide Toxicity Is Often Associated With The Odor of Almonds On Breath

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    Ryan Pan
    The article discusses the treatment of cyanide poisoning, which includes supportive care like oxygen supplementation and ventilator support. Activated charcoal may be used for conscious patients presenting soon after ingestion. Intravenous fluids are given to treat hypotension, while vasopressors are used for patients unresponsive to fluids. Sodium bicarbonate may be considered for severely acidemic patients. Cyanide toxicity is treated by administering sodium thiosulfate or sodium nitrate to increase the body's ability to remove cyanide, while methylene blue can treat methemoglobinemia caused by sodium nitrate or nitroprusside overdose. Thiocyanate toxicity from prolonged nitroprusside use is treated by

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    Symptoms: Cyanide Toxicity Is Often Associated With The Odor of Almonds On Breath

    Uploaded by

    Ryan Pan
    47 views2 pages
    The article discusses the treatment of cyanide poisoning, which includes supportive care like oxygen supplementation and ventilator support. Activated charcoal may be used for conscious patients presenting soon after ingestion. Intravenous fluids are given to treat hypotension, while vasopressors are used for patients unresponsive to fluids. Sodium bicarbonate may be considered for severely acidemic patients. Cyanide toxicity is treated by administering sodium thiosulfate or sodium nitrate to increase the body's ability to remove cyanide, while methylene blue can treat methemoglobinemia caused by sodium nitrate or nitroprusside overdose. Thiocyanate toxicity from prolonged nitroprusside use is treated by

    Original Description:

    Biochem Cyanidee

    Original Title

    Biochem Cyanidee

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    The article discusses the treatment of cyanide poisoning, which includes supportive care like oxygen supplementation and ventilator support. Activated charcoal may be used for conscious patients presenting soon after ingestion. Intravenous fluids are given to treat hypotension, while vasopressors are used for patients unresponsive to fluids. Sodium bicarbonate may be considered for severely acidemic patients. Cyanide toxicity is treated by administering sodium thiosulfate or sodium nitrate to increase the body's ability to remove cyanide, while methylene blue can treat methemoglobinemia caused by sodium nitrate or nitroprusside overdose. Thiocyanate toxicity from prolonged nitroprusside use is treated by

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    47 views2 pages

    Symptoms: Cyanide Toxicity Is Often Associated With The Odor of Almonds On Breath

    Uploaded by

    Ryan Pan
    The article discusses the treatment of cyanide poisoning, which includes supportive care like oxygen supplementation and ventilator support. Activated charcoal may be used for conscious patients presenting soon after ingestion. Intravenous fluids are given to treat hypotension, while vasopressors are used for patients unresponsive to fluids. Sodium bicarbonate may be considered for severely acidemic patients. Cyanide toxicity is treated by administering sodium thiosulfate or sodium nitrate to increase the body's ability to remove cyanide, while methylene blue can treat methemoglobinemia caused by sodium nitrate or nitroprusside overdose. Thiocyanate toxicity from prolonged nitroprusside use is treated by

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    5. What is the treatment for this condition?

    Initial management of cyanide poisoning is largely supportive and includes


    supplemental oxygen as well as airway and ventilator support. Activated charcoal
    may be considered in conscious patients who present soon after ingestion. Although
    adsorption of cyanide to charcoal is poor, binding may be sufficient to avert severe
    toxicity in some case. Intravenous crystalloid should be administered initially to
    resuscitate hypotensive patients. Patients who are unresponsive of fluid
    administration should be given vasopressors. Sodium bicarbonate may be
    considered in severely acidemic patients that are refractory to other supportive
    measures.
    Cyanide toxicity
    Acute cyanide toxicity occurs when the cyanide ions bind to tissue cytochrome
    oxidase and interfere with normal oxygen utilization. This as a result leads to
    metabolic acidosis, cardiac arrhythmias, and increased venous oxygen content (as a
    result of the inability to utilize oxygen). Another early sign of cyanide toxicity is the
    acute resistance to the hypotensive effects of increasing doses of sodium
    nitroprusside (tachyphylaxis). (It should be noted that tachyphylaxis implies acute
    tolerance to the drug following multiple rapid injections, as opposed to tolerance,
    which is caused by more chronic exposure). Cyanide toxicity can usually be avoided
    if the cumulative dose of sodium nitroprusside is less than 0.5 mg/kg/h.
    Symptoms: Cyanide toxicity is often associated with the odor of almonds on breath
    and can result in acidosis, tachycardia, mental status changes, and death.
    How to intervene: Patients with cyanide toxicity should be mechanically
    ventilated with 100% oxygen to maximize oxygen availability.
    Pharmacological treatment: Treatment of cyanide toxicity depends on increasing
    the kinetics of the two reactions by administeringsodium thiosulfate (150 mg/kg
    over 15 min) or 3% sodium nitrate (5 mg/kg over 5 min), which oxidizes hemoglobin
    to methemoglobin, or by limiting the administration of nitroprusside.
    Methemoglobinemia

    Methemoglobinemia from excessive doses of sodium nitroprusside or sodium nitrate


    can be treated with methylene blue (12 mg/kg of a 1% solution over 5 min), which
    reduces methemoglobin to hemoglobin.
    Thiocyanate toxicity
    Symptoms: Thiocyanate toxicity causes anorexia, fatigue, and mental status
    changes, including psychosis, weakness, seizures, tinnitus, and
    hyperreflexia. Thiocyanate is usually excreted in the urine. Toxicity can be
    minimized by avoiding prolonged administration of nitroprusside and by limiting
    drug use in patients with renal insufficiency. If necessary, thiocyanate can be
    removed by dialysis.
    1. What kind of article?

    The article is a controlled clinical trial.

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