GNIPST BULLETIN 2013

1118-1177-4796-9849-7562-5062

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCE

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06th September , 2013

Volume No.: 28

Issue No.: 04

Vision

Contents
Message from GNIPST Letter to the Editor News Update Health awareness Disease Outbreak News Forth Coming Events Drugs Update GNIPST Photo Gallery
For your comments/contributionOR

Campus News Students Section Editors Note Archive

For Back-Issues,
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1 EDITOR: Soumya Bhattacharya

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

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MESSAGE FROM GNIPST

GNIPST BULLETIN is the official publication of Guru Nanak Institute of Pharmaceutical Science & Technology. All the members of GNIPST are proud to publish the 28th Volume of GNIPST BULLETIN. Over the last two years this bulletin updating readers with different scientific, cultural or sports activities of this prestigious institute and promoting knowledge of recent development in Pharmaceutical and Biological Sciences. Students section is informing readers about some curious facts of drug discovery, science, sports and other relevant fields. We look forward to seeing your submission and welcome comments and ideas you may have.

LETTER TO THE EDITOR.

NEWS UPDATE

Detailed view of morphing parkinson's protein revealed (6 September, 2013)

th

Researchers have taken detailed images and measurements of the morphing structure of a brain protein thought to play a role in Parkinson's disease, information that could aid the development of medications to treat the condition. Researchers incubated the protein in a laboratory and then used an electron microscope and a technique called cryoelectron microscopy to snap thousands of pictures over 24 hours, capturing its changing shape. The protein was frozen at specific time intervals with liquid nitrogen. Read more

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Natural killer cell activity can be influenced by phosphorylating a protein in NK cells (6th September,
2013)

Scientists at the University of Veterinary Medicine, Vienna (Vetmeduni Vienna) provide evidence that NK cell activity can be influenced by phosphorylating a protein (STAT1) in NK cells. The results, which could be of immediate therapeutic relevance, are published in the journal Cell Reports. Read more

Drug patch treatment sees new breakthrough (6th

September, 2013)

An assistant professor with the Virginia Tech -- Wake Forest School of Biomedical Engineering has developed a flexible microneedle patch that allows drugs to be delivered directly and fully through the skin. The new patch can quicken drug delivery time while cutting waste, and can likely minimize side-effects in some cases, notable in vaccinations and cancer therapy Read more

Novel therapeutic cancer vaccine goes to human clinical trials (6th September, 2013)
A cross-disciplinary team of scientists, engineers, and clinicians announced today that they have begun a Phase I clinical trial of an implantable vaccine to treat melanoma, the most lethal form of skin cancer. Read more

Short-Term blood sugar control protects the kidney but not the heart in patients with diabetes (6th September,2013)
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Cell death protein could offer new antiinflammatory drug target (5thSeptember, 2013)

An international study has shown that short-term blood sugar control in patients with diabetes has a limited effect on their risk of cardiovascular problems, such as heart disease and stroke. Read more

Scientists in Melbourne, Australia, have revealed the structure of a protein that is essential for triggering a form of programmed cell death called necroptosis, making possible the development of new drugs to treat chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. Read more

HEALTH AWARENESS

Foodborne trematodiases
Foodborne trematodiases affect more than 56 million people throughout the world.They are caused by trematode worms ("flukes"), of which the most common species affecting humans are Clonorchis, Opisthorchis, Fasciola andParagonimus. People become infected through the consumption of raw or poorly cooked food: fish, crustaceans and vegetables that harbour the minute larval stages of the parasites . Transmission Foodborne trematodiases are zoonoses, i.e. they are naturally transmissible from vertebrate animals to people and vice versa. Direct transmission is however not possible, as the relevant causative parasites become infective only after having completed complex life-cycles that usually involve stages in intermediate, non-human hosts. The first intermediate host is in all cases a freshwater snail, while the second host differs: in clonorchiasis
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and opisthorchiasis it is a freshwater fish, in paragonimiasis it is a crustacean, while fascioliasis does not require a second intermediate host. The final host is always a mammal. People become infected when they ingest the second intermediate host that is infected with larval forms of the parasite. In the case of fascioliasis, people become infected when the larvae are ingested together with the aquatic vegetables to which they are attached . Epidemiology In 2005, more than 56 million people worldwide were infected with foodborne trematodes and over 7000 people died. Cases of foodborne trematodiases have been reported from over 70 countries worldwide; however South-East Asia and South America are the most affected areas. In these regions, infections with foodborne trematodes represent a significant public health problem. Within countries, transmission is often restricted to limited areas and reflects behavioural and ecological patterns, such as peoples food habits, methods of food production and preparation, and the distribution of the intermediate hosts. Information on the epidemiological status of foodborne trematode infections in Africa is largely missing. The economic impact of foodborne trematodiases is significant, and is mainly linked to losses in the expanding aquaculture industry due to restrictions on exports and reduced consumer demand. Symptoms The public health burden attributable to foodborne trematodiases is predominantly due to morbidity rather than mortality. Early and light infections often pass unnoticed, as they are asymptomatic or only scarcely symptomatic. Conversely, if the worm load is high, general malaise is common and severe pain can occur, especially in the abdominal region, and most frequently in the case of fascioliasis.
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Chronic infections are invariably associated with severe morbidity. Symptoms are mainly organ-specific and reflect the final location of the adult worms in the body. In clonorchiasis and opisthorchiasis, the adult worms lodge in the smaller bile ducts of the liver, causing inflammation and fibrosis of the adjacent tissues and eventually cholangiocarcinoma, a severe and fatal form of bile cancer. Both C. sinensis and O. viverrini, but not O. felineus, are classified as carcinogenic agents. In fascioliasis, the adult worms lodge in the larger bile ducts and the gall bladder, where they cause inflammation, fibrosis, blockage, colic pain and jaundice. Liver fibrosis and anaemia are also frequent. In paragonimiasis, the final location of the worms is the lung tissue. They cause symptoms that can be confounded with tuberculosis: chronic cough with blood-stained sputum, chest pain, dyspnoea (shortness of breath) and fever. Migration of the worms is possible: cerebral locations are the most severe. Prevention and control Control of foodborne trematodiases aims to reduce the risk of infection and at controlling associated morbidity. Veterinary public health measures and food safety practices are recommended to reduce the risk of infection, while, to control morbidity, WHO recommends improved access to treatment using safe and effective anthelminthic medicines (drugs that expel the worms). Treatment can be offered through preventive chemotherapy or individual case-management. Preventive chemotherapy involves a population-based approach whereby everyone in a given region or area is given medicines, irrespective of their infection status; it is recommended in areas where large numbers of individuals are infected. Individual case-management involves the treatment of people with confirmed or suspected infection: this approach is more appropriate where cases are less clustered and where health facilities are available.
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WHO response WHOs work on foodborne trematodiases is part of an integrated approach to the control of neglected tropical diseases, and includes: development of strategic directions and recommendations; support for mapping in endemic countries; support for pilot interventions and control programmes in endemic countries; support for monitoring and evaluation of implemented activities; and documentation of the burden of foodborne trematodiases and the impact of implemented interventions. WHO is working to include foodborne trematodiases in its mainstream preventive chemotherapy strategy and ensure that their worst consequences (cancers of the bile duct and others) are fully prevented. WHO has also negotiated an agreement with Novartis Pharma AG whereby this company will donate triclabendazole for the treatment of human fascioliasis and paragonimiasis. The medicines are shipped free of charge to ministries of health that apply for them. WHO invites all endemic countries to take advantage of this donation programme.

DISEASE OUTBREAK NEWS

Middle

East

respiratory

syndrome

coronavirus

(MERS-CoV) (30th August,2013)

WHO has been informed of an additional four laboratory-confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Saudi Arabia. Read more
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FORTHCOMING EVENTS

The 2nd Pharm. Tech IAPST International Conference on "New insights into
diseases and recent therapeutic approaches" from 17th to 19th January 2014 in Kolkata, India. Read more

DRUGS UPDATES

FDA approves Abraxane for pancreatic cancer (6th September, 2013)

late-stage

The U.S. Food and Drug Administration today expanded the approved uses of Abraxane (paclitaxel protein-bound particles for injectable suspension, albumin-bound) to treat patients with latestage (metastatic) pancreatic cancer. Read more

CAMPUS NEWS Teachers day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium. Azalea (exotic flower ) , the fresher welcome programme for
newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium. One day seminar cum teachers development programme for school teachers on the theme of Recent Trends of Life Sciences in Higher Education organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy
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Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science.

STUDENTS SECTION
WHO CAN ANS WER FIRS T????

Which biotechnological technique was developed by Kary Mullis in 1983? Isidor Rabi awarded Nobel Prize in 1944 in Physics for which remarkable work?
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Answer of Previous Issues Questions:

A) Dengue B)Dengue virus

Send your thoughts/ Quiz/Puzzles/games/writeups or any other contributions for Students Section& answers of this Section [email protected]

EDITORS NOTE I am proud to publish the 4th issue of 28th Volume of GNIPST BULLETIN. GNIPST BULLETIN now connected globally through facebook account GNIPST bulletin I want to convey my thanks to all the GNIPST members and the readers for their valuable comments, encouragement and supports. I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha and Mr. Debabrata Ghosh Dastidar for their kind co-operation and technical supports. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

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ARCHIVE The following B.Pharm. final year students have qualified, GPAT-2013. We congratulate them all.

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The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day. GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18.
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The number of seats in B.Pharm. has been increased from 60 to 120. AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta. c. Grant-in-aid sanctioned:Rs. 16,25000/- only d. Approved duration: 3 years e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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