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    Magnesium Sulfate

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    Trixie Anne Gamotin
    Magnesium sulfate is available as granules or injections and is administered orally, intramuscularly, or intravenously. It acts as a cofactor for enzymes, prevents seizures by blocking neuromuscular transmission, and treats constipation by retaining water in the intestines. Common indications include constipation, torsades de pointes, muscle effects of barium poisoning, seizures, and toxemias of pregnancy. Adverse reactions include weakness, respiratory and heart issues, and hypocalcemia. Nursing responsibilities include monitoring for contraindications, administering properly, observing for side effects, and discontinuing appropriately.

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    Magnesium Sulfate

    Uploaded by

    Trixie Anne Gamotin
    1K views1 page
    Magnesium sulfate is available as granules or injections and is administered orally, intramuscularly, or intravenously. It acts as a cofactor for enzymes, prevents seizures by blocking neuromuscular transmission, and treats constipation by retaining water in the intestines. Common indications include constipation, torsades de pointes, muscle effects of barium poisoning, seizures, and toxemias of pregnancy. Adverse reactions include weakness, respiratory and heart issues, and hypocalcemia. Nursing responsibilities include monitoring for contraindications, administering properly, observing for side effects, and discontinuing appropriately.

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    DRUG STUDY

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    MAGNESIUM SULFATE

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    Magnesium sulfate is available as granules or injections and is administered orally, intramuscularly, or intravenously. It acts as a cofactor for enzymes, prevents seizures by blocking neuromuscular transmission, and treats constipation by retaining water in the intestines. Common indications include constipation, torsades de pointes, muscle effects of barium poisoning, seizures, and toxemias of pregnancy. Adverse reactions include weakness, respiratory and heart issues, and hypocalcemia. Nursing responsibilities include monitoring for contraindications, administering properly, observing for side effects, and discontinuing appropriately.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    1K views1 page

    Magnesium Sulfate

    Uploaded by

    Trixie Anne Gamotin
    Magnesium sulfate is available as granules or injections and is administered orally, intramuscularly, or intravenously. It acts as a cofactor for enzymes, prevents seizures by blocking neuromuscular transmission, and treats constipation by retaining water in the intestines. Common indications include constipation, torsades de pointes, muscle effects of barium poisoning, seizures, and toxemias of pregnancy. Adverse reactions include weakness, respiratory and heart issues, and hypocalcemia. Nursing responsibilities include monitoring for contraindications, administering properly, observing for side effects, and discontinuing appropriately.

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    Drug Data Generic Name Magnesium Sulfate Trade Name Martham Minimum Dose 1-2 g qH by IV infusion Maximum Dose

    4-6 g qH by IV infusion Contents Magnesium sulfate Availability and color - Granules- 40 mEq/5 g - Injection0.325, 0.65, 1, 4 mEq/mL Routes of administration Oral Intramuscular Intravenous

    Classification Pharmacologic Class Mineral, Electrolyte Therapeutic Class Antiepileptic, Laxative; Mineral, electrolyte replacement Pregnancy Risk Factor A B (Laxative)

    Mechanism of Action Cofactor of many enzyme systems involved in neurochemical transmission and muscular excitability; prevents or controls seizures by locking the neuromuscular transmission; attracts and retains the water in the intestinal lumen and distends the bowel to promote mass movement and relieve constipation. Pharmacokinetics A: Following administration, 30-50% of the dose is absorbed from the small intestine. D: Crosses the placenta and small amounts enter the breast milk. M: Unknown E: Via urine and feces. Route Oral IM IV Onset 1-2 hr 60 min Immediate Peak unknown unknown unknown Duration 3-4 hr 3-4 hr 30 min

    Indication General Indications - Constipation - Torsades de pointes - Muscle stimulating effects of barium poisoning - Reduction of cerebral oedema. Hypomagnesaemia - Seizures associated with epilepsy, glomerulonephritis or hypothyroidism. - Toxemias of pregnancy - Boils and carbuncles

    Contraindications Concentrations - Allergy to magnesium products - Abdominal pain - Nausea - Vomiting - Acute surgical abdomen - Fecal impaction - Intestinal and biliary tract obstruction - Hepatitis - Myocardial damage - Heart blocks - 2 hr preceding delivery Precaution - Renal insufficiency Drug interaction Drug to drug - Potentiation of neuromuscular blockade produced by nondepolarizing neuromuscular relaxants Drug to food - none reported

    Adverse Reaction CNS: Weakness, drowsiness, dizziness, fainting, sweating Respiratory: Decreased respiratory rate CV: Palpitations GI: Excessive bowel activity, perianal irritation Metabolic: Magnesium intoxication, hypocalcemia with tetany

    Nursing Responsibilities Before - Assess for contraindicated conditions. - Monitor knee-jerk reflex before repeated parenteral administration. - Give as laxative as temporary measure. - Reserve IV use in eclampsia for life-threatening situations. - Observe the 15 rights in drug administration. During - Give IM route by deep IM injection. - Monitor serum magnesium levels. - Do not give oral MgSO4 with abdominal pain, nausea, or
    vomiting. - Do not administer if knee-jerk reflexes are suppressed - Monitor bowel function. After - Arrange to discontinue administration as soon as levels are within normal limits and desired clinical response is obtained. - Discontinue if diarrhea or cramping occurs. - Arrange for dietary measures, exercise and environmental control to return to normal bowel activity. - Report sweating, flushing, muscle tremors or twitching, inability to move extremities. - Maintain urine output at a level of 100 mL every 4 hr during parenteral administration.

    Drug Half Life Unknown

    GAMOTIN,TRIXIE ANNE G.

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