Drug Data Classification Mechanism of Action Indication Contraindications Adverse Reaction Nursing Responsibilities

Generic Name Pharmacologic Acts directly on vascular smooth General Indications Concentrations CNS: Headache, peripheral Before
Hydralazine Class muscle to cause vasodilation, - Hypertension - Hypersensitivity neuritis, dizziness, tremors, - Check blood pressure.
Vasodilator primarily arteriolar, decreasing - Eclampsia - CAD psychotic reactions, characterized - Arrange for CBC, LE cell
Trade Name peripheral resistance; maintains or - mitral valvular by depression, disorientation, preparations, and ANA titers before
Apresoline, Novo- Therapeutic Class increases renal and cerebral flow. rheumatic heart anxiety therapy.
Hylazin Antihypertensive disease - Assess for contraindicated
Pharmacokinetics CV: Palpitations, tachycardia, conditions.
Precaution
Minimum Dose Pregnancy Risk angina pectoris, hypotension, - Observe the 15 rights of drug
- with CAV’s
5 mg/hr by IV Factor A: Rapidly absorbed from the GI paradoxical pressor response, administration.
- increased intracranial
infusion C tract after oral administration. orthostatic hypotension - Assess bowel sounds.
pressure
D: About 90% bound to plasma - Assess voiding pattern.
- severe hypertension
Maximum Dose proteins.
with uremia GI: Anorexia, nausea, vomiting,
10 mg by IV M: Undergoes considerable first- During
- advanced renal diarrhea, constipation, paralytic
infusion pass metabolism by acetylation in - Give oral drug with food.
damage ileus
the GI mucosa and liver. - Use parenteral drug immediately
- slow acetylators
Contents E: Mainly excreted in urine as after opening ampule.
- lactation
Hydralazine HCl metabolites. GU: Difficult micturition, impotence - Discard discolored solutions.
- pregnancy
- Arrange for CBC, LE cell
- pulmonary
Availability and Route Hematologic: Blood dyscrasias preparations, and ANA titers during
hypertension
color Onset prolonged therapy.
- Tablets- 10, 25, Peak - Instruct to take drug exactly as
Duration Drug interaction Hypersensitivity: Rash, urticaria,
50, 100 mg Oral prescribed.
Drug to drug pruritus, fever, chills, arthralgia,
- Injection- 20 Rapid
- Increased eosinophilia; rarely, hepatits,
mg/mL 1-2 hr After
6-12 hr pharmacologic effects obstructive jaundice - Withdraw drug gradually.
Routes of IM of beta-adrenergic
Rapid - Discontinue if blood dyscrasias
administration blockers and
10-20 min Other: Nasal congestion, flushing, occur.
Oral 2-4 hr hydralazine when given
edema, muscle cramps, - Arrange for pyridoxine therapy if
Intramuscular IV concomitantly
Rapid
lymphadenopathy, splenomegaly, patient develops symptoms of
Intravenous 10-20 min dyspnea, lupus-like syndrome, peripheral neuritis.
Drug to food
2-4 hr possible carcinogenesis, - Monitor for orthostatic
- Increased
lacrimation, conjunctivitis hypotension.
bioavailability of oral
Drug Half Life - Report persistent or severe
hydralazine given with
3-7 hr constipation, unexplained fever or
food.
malaise, muscle or joint aching,
chest pain, rash, numbness,
tingling.
- Do proper documentation.
Source: Source: Source: Source: Source: Source: Source:
Karch, Amy: 2009 http://mims.com.ph/, http://mims.com.ph/, Karch, Amy: 2009 http://mims.com.ph/ Karch, Amy: 2009 Lippincott’s Karch, Amy: 2009 Lippincott’s Nursing Drug Karch, Amy: 2009 Lippincott’s Nursing Drug
Lippincott’s Nursing Drug Karch, Amy: 2009 Lippincott’s Nursing Drug Guide, p. 588 Nursing Drug Guide, p. 589 Guide, p. 589 Guide, pp. 589-590
Guide, p. 588 Lippincott’s Nursing Drug
Guide, p. 588