High Blood Pressure Epilepsy Pregnancy Breast: Dry Mouth Headache

Download as docx, pdf, or txt
Download as docx, pdf, or txt
You are on page 1of 3

PRECAUTIONS: Tell your doctor your medical history, especially of: an overactive thyroid,

heart disease, high blood pressure, epilepsy, diabetes, drug allergies. This medication should be
used only when clearly needed during pregnancy. Discuss the risk and benefits with your doctor.
This drug may be excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medications
you use, including: beta-blockers (e.g., propranolol, timolol), all asthma medications, ephedrine,
epinephrine, pseudoephedrine, antidepressants, MAO inhibitors (e.g., furazolidone, linezolid,
phenelzine, selegiline, tranylcypromine), diuretics (e.g., hydrochlorothiazide). It is important to
read the labels carefully on all over-the-counter medications, especially those used for colds,
allergies, asthma or diets as they may contain ingredients mentioned above. Do not start or stop
any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency
room immediately. US residents can call the US national poison hotline at 1-800-222-1222.
Canadian residents should call their local poison control center directly. Symptoms of overdose
may include chest pain, fast or irregular heartbeat, headache, tremors, nervousness, weakness,
and dizziness.

NOTES: Do not share this medication with others.

MISSED DOSE: Ask your doctor about what action to take if you should miss a dose. Do not
"double-up" the dose.

STORAGE: Store at temperatures below 86 degrees F (30 degrees C) away from moisture and
sunlight. Do not store in the bathroom.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For
enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

Dry mouth, irritated throat, dizziness, headache, lightheadedness,


heartburn, loss of appetite, altered taste sensation,
restlessness, anxiety, nervousness, trembling, and sweating

This drug relaxes the smooth muscle in the lungs and opens airways
to improve breathing. It is used to treat asthma, chronic
bronchitis, emphysema and to prevent exercise-related asthma.

Indications

Salbutamol is used in cases of bronchospasm in patients with reversible airway obstruction: mild
and moderate attacks of dyspnea in patients suffering from bronchial asthma; mild and moderate
bronchoobstruction in patients with chronic bronchitis and lung emphysema.

Dosage and administration


Adults and children over 12 years: The recommended dose is 2 - 4 mg (5 - 10 ml syrup) 3 - 4
times daily. The maximal daily dose should not exceed 32 mg (divided in 3 or 4 doses).
Children: between 2 and 6 years, the dose is 0.1 - 0.2 mg/kg body weight given 3 times daily.
The maximal daily dose must not exceed 4 mg, 3 times daily, and the daily dose for 6 - 12 years-
old children is to 24 mg daily, divided in 3 or 4 doses.

Contraindications

Hypersensitivity to some of the drug ingredients.

Special warnings and precautions

The drug should be used with caution in patients with heart diseases and probable rhythm
disorders (advanced high grade valvular diseases, ischemic heart disease, cardiomyopathy, etc.),
as well as in patients with diabetes mellitus. The safety, efficacy, and dosage of the drug in
bellow 2 year-old children have not been established. The drug should be avoided during
pregnancy, particularly during the first trimester and during labor, because it is established that
the high doses can suppress the contractions of the uterus. There are no data for risks related with
the administration of the drug in breast-feeding women. Because of the possibility for induction
of tremor, dizziness, and weakness, the drug should be used cautiously in drivers and people
working with machines.

Drug interactions

In cases of concurrent administration with MAO-inhibitors or antidepressants, a potentiation of


the cardiovascular effects is observed. The β-blockers antagonize the action of Salbutamol. In
cases of simultaneous administration with digitalis glycosides, theophylline, oral antidiabetic
agents, insulin, sympathomimetics, Salbutamol can increase the toxicity of these agents.

Adverse reactions

Headache; tremor; tachycardia; hypertension; anxiety. Rarely nausea, vomiting, and skin rash
can be observed.

Pharmacological mechanisms

Salbutamol is a selective 2-adrenomimetic agent stimulating mainly the 2-adrenergic receptors


and to a lesser extent 1-adrenergic receptors in the myocardium. The stimulation of the 2
receptors leads to adenylate cyclase activation and cAMP accumulation, alterations in the methyl
transferase activity, decrease in the calcium ion intracellular concentration. Due to these changes
bronchial smooth muscle relaxation and inhibition of mast cell degranulation develop. The
antiasthmatic action of Salbutamol is related to the decrease of edema and mucus secretion. The
drug has no influence on the heart activity, and there are no tachycardia and blood pressure
elevation.

Supplied
Vial, containing 125 ml syrup.

Expiry

2 years.

You might also like