Oncogenetics

Abstract
BACKGROUND:
Risk-reducing mastectomy (RRM) decreases breast cancer (BC) risk in BRCA1/2 mutation carriers by up to 95%, but the Italian attitude towards this procedure is reluctant.
PATIENTS AND METHODS:
This is an observational study with retrospective design, using quantitative and qualitative research methods, aimed at evaluating the attitude towards RRM by rapid genetic counselling and testing (RGCT), at the time of BC diagnosis, compared with traditional genetic counselling and testing (TGCT), after previous BC surgery. Secondary aims were to investigate patient satisfaction after RRM and the rate of occult tumour in healthy breasts. A total of 1168 patients were evaluated: 1058 received TGCT, whereas 110 underwent RGCT.
RESULTS:
In TGCT, among 1058 patients, 209 (19.7%) mutation carriers were identified, with the rate of RRM being 4.7% (10 of 209). Conversely in RGCT, among 110 patients, 36 resulted positive, of which, 15 (41.7%) underwent bilateral mastectomy at the BC surgery time, showing an overall good satisfaction, measured by interpretative phenomenological analysis 12 months after the intervention.
CONCLUSIONS:
Our study shows that RGCT in patients with a hereditary profile is associated with a high rate of RRM at the BC surgery time, this being the pathway offered within a multidisciplinary organization.

Santé mondiale - Soutenir le mouvement de personnalisation en santé en Afrique

Le présent livre blanc fait suite au colloque de Libreville qui a eu le mérite de permettre de fructueux échanges entre praticiens et universitaires sur divers aspects de la médecine personnalisée préférentiellement  africain. Il s'agit ici de soutenir toutes les actions visant à promouvoir l’intégration de la composante des soins de santé ajustés aux particularités individuelles dans les curricula de formation des facultés de médecine qui tiennent compte des spécificités locales.

Lipoma is a rare intraoral tumor. Recurrences after excision are minimum.  It’s important to differentiate it from other lesions of the oral cavity presenting as a swelling. Further investigations into the etiopathogenesis of intraoral lipomas, would provide more light  in  the direction of their development and towards better management and treatment options. Here we present a case report of an intra-oral lipoma in relation to floor of the mouth in a 40 year old male patient.