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Contents Vol. 27, 2009

Dementia and Geriatric Cognitive Disorders

Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/dem_issues

Vol. 27, 2009 Editor-in-Chief Editorial Board V. Chan-Palay, New York, N.Y. M. Altieri, Rome D.L. Bachmann, Charleston, S.C. C. Ballard, London B. Lynn Beattie, Vancouver A. Brun, Lund J. Cummings, Los Angeles, Calif. M.J. de Leon, New York, N.Y. R.S. Doody, Houston, Tex. R. Fama, San José, Calif. H. Feldman, Vancouver H. Förstl, Munich S.E. Gandy, New York, N.Y. C.-G. Gottfries, Mölndal L. Gustafson, Lund F.F. Hefti, Philadelphia, Pa. E.C. Hirsch, Paris A. Homma, Tokyo P.G. Ince, Sheffield K.A. Jellinger, Vienna P. Johannsen, Copenhagen K. Maeda, Kobe C.L. Masters, Melbourne B.L. Miller, San Francisco, Calif. U.P. Mosimann, Bern J.-M. Orgogozo, Bordeaux M. Patterson, Cleveland, Ohio J. Pérez-Tur, Valencia D. Price, Baltimore, Md. K. Ritchie, Montpellier G.C. Roman, San Antonio, Tex. I. Rosén, Lund M.N. Rossor, London E. Salmon, Liège P. Scheltens, Amsterdam H. Soininen, Kuopio M. Takeda, Osaka T. Tanaka, Osaka K. Urakami, Yonago F.R.J. Verhey, Maastricht G. Waldemar, Copenhagen B. Winblad, Stockholm Basel • Freiburg • Paris • London • New York • Bangalore • Bangkok • Shanghai • Singapore • Tokyo • Sydney S. Karger Medical and Scientific Publishers Basel • Freiburg • Paris • London • New York • Bangalore • Bangkok • Shanghai • Singapore • Tokyo • Sydney Disclaimer The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Fax +41 61 306 12 34 E-Mail [email protected] www.karger.com All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see ‘General Information’). © Copyright 2009 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel Contents Vol. 27, 2009 50 Does a Reliable Decline in Mini Mental State Examination No. 1 Total Score Predict Dementia? Diagnostic Accuracy of Two Reliable Change Indices Review Article 1 Functional Magnetic Resonance Imaging of Compensatory Neural Recruitment in Aging and Risk for Alzheimer’s Disease: Review and Recommendations Han, S.D. (Chicago, Ill./Maywood, Ill.); Bangen, K.J.; Bondi, M.W. (San Diego, Calif.) Original Research Articles 11 Plasma Homocysteine and Risk of Mild Cognitive Impairment Reitz, C.; Tang, M.-X. (New York, N.Y.); Miller, J.; Green, R. (Davis, Calif.); Luchsinger, J.A. (New York, N.Y.) 18 Associations between Patterns of EEG Abnormalities and Diagnosis in a Large Memory Clinic Cohort Liedorp, M.; van der Flier, W.M. (Amsterdam); Hoogervorst, E.L.J. (Utrecht); Scheltens, P.; Stam, C.J. (Amsterdam) 24 Diabetes as a Risk Factor for Cognitive Decline in Older Patients Maggi, S.; Limongi, F.; Noale, M.; Romanato, G. (Padua); Tonin, P. (Venice); Rozzini, R. (Brescia); Scafato, E. (Rome); Crepaldi, G. (Padua) for the ILSA Study Group 34 Cognitive Impairment and Dementia in Elderly People Living in Rural Benin, West Africa Guerchet, M. (Limoges); Houinato, D. (Limoges/Cotonou); Paraiso, M.N. (Limoges/Ouidah); von Ahsen, N. (Göttingen); Nubukpo, P. (Limoges); Otto, M. (Ulm); Clément, J.-P.; Preux, P.-M. (Limoges); Dartigues, J.-F. (Bordeaux) 42 Serum Lipids Are Related to Alzheimer’s Pathology in Nursing Home Residents Lesser, G.T.; Haroutunian, V.; Purohit, D.P.; Schnaider Beeri, M.; Schmeidler, J.; Honkanen, L.; Neufeld, R.; Libow, L.S. (New York, N.Y.) © 2009 S. Karger AG, Basel Fax +41 61 306 12 34 E-Mail [email protected] www.karger.com Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/dem_issues Hensel, A.; Luck, T.; Luppa, M.; Glaesmer, H. (Leipzig); Angermeyer, M.C. (Gösing a.W.); Riedel-Heller, S.G. (Leipzig) 59 Genetic Analysis of Alzheimer’s Disease in the Uppsala Longitudinal Study of Adult Men Giedraitis, V.; Kilander, L.; Degerman-Gunnarsson, M.; Sundelöf, J.; Axelsson, T.; Syvänen, A.-C.; Lannfelt, L.; Glaser, A. (Uppsala) 69 Korean Version of the Baylor Profound Mental Status Examination: A Brief Staging Measure for Patients with Severe Alzheimer’s Disease Na, H.R.; Lee, S.H. (Seongnam); Lee, J.S. (Cheju); Doody, R.S. (Houston, Tex.); Kim, S.Y. (Seoul) 76 Factors Underlying Caregiver Stress in Frontotemporal Dementia and Alzheimer’s Disease Mioshi, E. (Sydney, N.S.W./Cambridge); Bristow, M.; Cook, R. (Cambridge); Hodges, J.R. (Sydney, N.S.W./Cambridge) 82 Interleukin-1␣ –889 C/T Polymorphism in Turkish Patients with Late-Onset Alzheimer’s Disease Dursun, E.; Gezen-Ak, D.; Ertan, T.; Bilgiç, B.; Gürvit, H.; Emre, M.; Eker, E.; Engin, F.; Uysal, Ö.; Yilmazer, S. (Istanbul) 88 Plasma Homocysteine Levels and Different Forms of Vascular Disease in Patients with Dementia and Other Psychogeriatric Diseases Nilsson, K.; Gustafson, L.; Hultberg, B. (Lund) 96 Neuroanatomy of Apathy and Disinhibition in Frontotemporal Lobar Degeneration Massimo, L.; Powers, C.; Moore, P.; Vesely, L.; Avants, B.; Gee, J.; Libon, D.J.; Grossman, M. (Philadelphia, Pa.) No. 2 No. 3 Review Articles Review Article 105 Functional Outcome in Delusional Alzheimer Disease Patients. Cognitive Screening Fischer, C.E.; Verhoeff, N.P.L.G.; Churchill, K.; Schweizer, T.A. (Toronto, Ont.) Pinto, E.; Peters, R. (London) 164 Memantine Therapy of Behavioral Symptoms in Community-Dwelling Patients with Moderate to Severe Alzheimer’s Disease Grossberg, G.T. (St. Louis, Mo.); Pejović, V.; Miller, M.L. (Chicago, Ill.); Graham, S.M. (Jersey City, N.J.) Original Research Articles 111 Association of Cognitive Impairment with Serum Lipid/ Lipoprotein among Chinese Nonagenarians and Centenarians Huang, C.-Q.; Dong, B.-R.; Wu, H.-M.; Zhang, Y.-L.; Wu, J.-H.; Lu, Z.-C.; Flaherty, J.H. (Chengdu) 117 Changes in Cortical Activation during Retrieval of Clock Time Representations in Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease Leyhe, T.; Erb, M.; Milian, M.; Eschweiler, G.W. (Tübingen); Ethofer, T. (Tübingen/Geneva); Grodd, W.; Saur, R. (Tübingen) 133 Frontal Assessment Battery and Brain Perfusion Imaging in Early Dementia Yoshida, H.; Terada, S.; Sato, S.; Kishimoto, Y.; Ata, T.; Ohshima, E.; Honda, H.; Ishihara, T.; Kuroda, S. (Okayama) 139 Risk Factors for Falls in Community-Dwelling Patients with Alzheimer’s Disease and Dementia with Lewy Bodies: Walking with Visuocognitive Impairment May Cause a Fall Kudo, Y.; Imamura, T.; Sato, A.; Endo, N. (Niigata) 147 Education Attenuates the Association between Dietary Patterns and Cognition Akbaraly, T.N. (London); Singh-Manoux, A. (London/Paris); Marmot, M.G.; Brunner, E.J. (London) 155 Effect of Oxcarbazepine in the Treatment of Agitation and Aggression in Severe Dementia Sommer, O.H. (Reinsvoll); Aga, O. (Hokksund); Cvancarova, M.; Olsen, I.C. (Oslo); Selbaek, G. (Ottestad); Engedal, K. (Oslo) 173 Predictive Value of Mild Cognitive Impairment for Dementia. The Influence of Case Definition and Age Baars, M.A.E.; van Boxtel, M.P.J.; Dijkstra, J.B. (Maastricht); Visser, P.J. (Maastricht/Amsterdam); van den Akker, M.; Verhey, F.R.J.; Jolles, J. (Maastricht) 182 Presymptomatic Generalized Brain Atrophy in Frontotemporal Dementia Caused by CHMP2B Mutation Rohrer, J.D.; Ahsan, R.L.; Isaacs, A.M. (London); Nielsen, J.E. (Copenhagen); Ostergaard, L. (Aarhus); Scahill, R.; Warren, J.D.; Rossor, M.N.; Fox, N.C. (London); Johannsen, P. (Copenhagen) the FReJA consortium 187 Self-Appraised, Informant-Reported, and Objective Memory and Cognitive Function in Mild Cognitive Impairment Chung, J.C.C.; Man, D.W.K. (Hong Kong) 194 Biomarkers in Relation to Cognitive Reserve in Patients with Mild Cognitive Impairment – Proof of Concept Rolstad, S.; Nordlund, A.; Eckerström, C.; Gustavsson, M.H.; Zetterberg, H.; Wallin, A. (Mölndal) IV 201 Literature Review of the Clock Drawing Test as a Tool for A Systematic Review Dement Geriatr Cogn Disord Vol. 27, 2009 Original Research Articles 214 Neuropathological Investigation of Regions Responsible for Semantic Aphasia in Frontotemporal Lobar Degeneration Yamamoto, R.; Iseki, E.; Higashi, S.; Murayama, N.; Minegishi, M.; Sato, K. (Tokyo); Hino, H.; Fujisawa, K.; Kosaka, K.; Togo, T.; Katsuse, O.; Uchikado, H.; Furukawa, Y. (Yokohama); Yoshida, M.; Hashizume, Y. (Aichi); Arai, H. (Tokyo) 224 Diagnosis of Mild Cognitive Impairment Revisited after One Year. Preliminary Results of a Prospective Study Diniz, B.S.; Nunes, P.V.; Yassuda, M.S.; Forlenza, O.V. (São Paulo) 232 Long-Term Safety and Efficacy of Donepezil in Patients with Severe Alzheimer’s Disease: Results from a 52-Week, Open-Label, Multicenter, Extension Study in Japan Homma, A.; Imai, Y. (Tokyo); Tago, H. (Fukushima City); Asada, T. (Ibaraki); Shigeta, M.; Iwamoto, T. (Tokyo); Takita, M. (Fukuoka;); Arimoto, I.; Koma, H.; Takase, T.; Ohbayashi, T. (Tokyo) 240 Cardiovascular Disease Risk Factors and Progression of Alzheimer’s Disease Abellan van Kan, G.; Rolland, Y.; Nourhashémi, F.; Coley, N.; Andrieu, S.; Vellas, B. (Toulouse) on behalf of the REAL.FR group 247 Validation Study of the Mini-Mental State Examination in a Malay-Speaking Elderly Population in Malaysia Ibrahim, N.M. (Kuala Lumpur); Shohaimi, S. (Selangor); Chong, H.-T.; Rahman, A.H.A.; Razali, R.; Esther, E.; Basri, H.B. (Kuala Lumpur) 254 A SPECT Study of Sleep Disturbance and Alzheimer’s Disease Ismail, Z.; Herrmann, N.; Francis, P.L.; Rothenburg, L.S.; Lobaugh, N.J.; Leibovitch, F.S.; Black, S.E.; Lanctôt, K.L. (Toronto, Ont.) 260 Assessment of Patient and Caregiver Experiences of Dementia-Related Symptoms: Development of the Multidimensional Assessment of Neurodegenerative Symptoms Questionnaire Locke, D.E.C. (Scottsdale, Ariz.); Dassel, K.B.; Hall, G.; Baxter, L.C. (Phoenix, Ariz.); Woodruff, B.K.; Hoffman Snyder, C. (Scottsdale, Ariz.); Miller, B.L. (San Francisco, Calif.); Caselli, R.J. (Scottsdale, Ariz.) 273 No Genetic Association between Polymorphisms of Heme Oxygenase 1 and 2 and Alzheimer’s Disease in a Japanese Population Shibata, N.; Ohnuma, T.; Baba, H.; Arai, H. (Tokyo) 278 Characteristic Profiles of Instrumental Activities of Daily Living in Different Subtypes of Mild Cognitive Impairment Kim, K.R.; Lee, K.S. (Seoul); Cheong, H.-K. (Suwon); Eom, J.-S. (Cheongju); Oh, B.H. (Seoul); Hong, C.H. (Suwon) 286 Interaction between Interleukin-8 and Methylenetetrahydrofolate Reductase Genes Modulates Alzheimer’s Disease Risk Li, K.; Liu, S.; Yao, S.; Wang, B.; Dai, D.; Yao, L. (Harbin) 292 Age in High-Functioning Healthy Men Is Associated with Nonlinear Decline in Some ‘Executive’ Functions in Late Middle Age Silver, H.; Goodman, C. (Haifa); Bilker, W. (Philadelphia, Pa.) Contents No. 4 No. 5 Original Research Articles Original Research Articles 301 Use of the Virtual Action Planning Supermarket for the Diagnosis of Mild Cognitive Impairment. A Preliminary Study Werner, P.; Rabinowitz, S. (Haifa); Klinger, E. (Paris); Korczyn, A.D. (Tel Aviv); Josman, N. (Haifa) 310 Development of the Subjective Memory Complaints Questionnaire Youn, J.C. (Yongin); Kim, K.W. (Seoul/Seongnam); Lee, D.Y. (Seoul); Jhoo, J.H. (Chuncheon); Lee, S.B. (Seoul); Park, J.H. (Gyeonggido); Choi, E.A. (Gonju); Choe, J.Y.; Jeong, J.W.; Choo, I.H.; Woo, J.I. (Seoul) 318 Flanking Markers of Cystatin C (CST3) Gene Do Not Show Association with Alzheimer’s Disease Helisalmi, S.; Väkevä, A.; Hiltunen, M.; Soininen, H. (Kuopio) 322 The Effect of Recent Consumption of Caffeine-Containing Foodstuffs on Neuropsychological Tests in the Elderly Lesk, V.E.; Honey, T.E.M.; de Jager, C.A. (Oxford) 329 Establishment of a Predominantly African-American Cohort for the Study of Alzheimer’s Disease. The South Carolina Alzheimer’s Disease Clinical Core Bachman, D.L.; Stuckey, M.; Ebeling, M.; Wagner, M.T. (Charleston, S.C.); Evans, W.J. (Florence, S.C.); Hirth, V. (Columbia, S.C.); Walker, A. (Charleston, S.C.); Memon, M. (Spartanburg, S.C.); Joglekar, R. (Anderson, S.C.); Faison, W.; Mintzer, J.E. (Charleston, S.C.) 337 Sense of Competence in a Dutch Sample of Informal Caregivers of Frontotemporal Dementia Patients Riedijk, S.; Duivenvoorden, H.; Van Swieten, J. (Rotterdam); Niermeijer, M. (Nijmegen); Tibben, A. (Leiden) 344 Agreement in Cognitive and Clinical Assessments in Alzheimer’s Disease Tractenberg, R.E. (Washington, D.C./La Jolla, Calif.); Aisen, P.S. (La Jolla, Calif.) 353 The Neuropsychological Performance of Nondemented Puerto Rican Nonagenarians Carrión-Baralt, J.R.; Meléndez-Cabrero, J. (New York, N.Y./San Juan, P.R.); Schnaider Beeri, M. (New York, N.Y.); Sano, M.; Silverman, J.M. (New York, N.Y./Bronx, N.Y.) 361 Validation of the Danish Addenbrooke’s Cognitive Examination as a Screening Test in a Memory Clinic Stokholm, J.; Vogel, A.; Johannsen, P.; Waldemar, G. (Copenhagen) 366 Observation of Hand Movements by Older Persons with Dementia: Effects on Cognition. A Pilot Study Eggermont, L.H.P.; Swaab, D.F.; Hol, E.M. (Amsterdam); Scherder, E.J.A. (Amsterdam/Groningen) 375 Impact of Vascular Risk Factors and Diseases on Cognition in Persons with Mild Cognitive Impairment Villeneuve, S.; Belleville, S.; Massoud, F.; Bocti, C.; Gauthier, S. (Montreal, Que.) 382 Uric Acid and Dementia in Community-Dwelling Older Persons Ruggiero, C.; Cherubini, A. (Perugia); Lauretani, F.; Bandinelli, S. (Florence); Maggio, M. (Parma); Di Iorio, A. (Chieti); Zuliani, G. (Ferrara); Dragonas, C. (Nuremberg); Senin, U. (Perugia); Ferrucci, L. (Baltimore, Md.) 390 Differential Impact of Apathy and Depression in the Development of Dementia in Mild Cognitive Impairment Patients Vicini Chilovi, B.; Conti, M.; Zanetti, M. (Brescia); Mazzù, I. (Messina); Rozzini, L.; Padovani, A. (Brescia) 399 Differences Exist in the Cognitive Profile of Mild Alzheimer’s Disease and Subcortical Ischemic Vascular Dementia Kandiah, N.; Narasimhalu, K.; Lee, J.; Chen, C.L.P.H. (Singapore) 404 Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment. Design and Cohort Baseline Characteristics of the German Dementia Competence Network Kornhuber, J. (Erlangen); Schmidtke, K. (Freiburg); Frölich, L. (Mannheim); Perneczky, R (Munich); Wolf, S. (Göttingen); Hampel, H. (Munich); Jessen, F. (Bonn); Heuser, I.; Peters, O. (Berlin); Weih, M. (Erlangen); Jahn, H. (Hamburg); Luckhaus, C. (Düsseldorf); Hüll, M. (Freiburg); Gertz, H.-J. (Leipzig); Schröder, J. (Heidelberg); Pantel, J. (Frankfurt); Rienhoff, O. (Göttingen); Seuchter, S.A. (Erlangen); Rüther, E. (Göttingen); Henn, F. (Mannheim); Maier, W. (Bonn); Wiltfang, J. (Erlangen/Essen) 418 Stability of Different Subtypes of Mild Cognitive Impairment among the Elderly over a 2- to 3-Year Follow-Up Period Loewenstein, D.A. (Miami Beach, Fla./Miami, Fla./Tampa, Fla.); Acevedo, A. (Miami, Fla./Tampa, Fla.); Small, B.J. (Tampa, Fla.); Agron, J. (Miami, Fla./ Tampa, Fla.); Crocco, E. (Miami, Fla.); Duara, R. (Miami Beach, Fla./ Miami, Fla.) 424 Comparison of EXIT-25 and the Frontal Assessment Battery for Evaluation of Executive Dysfunction in Patients Attending a Memory Clinic Moorhouse, P.; Gorman, M.; Rockwood, K. (Halifax, N.S.) 429 A Subtest of the MMSE as a Valid Test of Episodic Memory? Comparison with the Free and Cued Reminding Test Carcaillon, L.; Amieva, H.; Auriacombe, S.; Helmer, C.; Dartigues, J.-F. (Bordeaux) 439 Minimizing Misdiagnosis: Psychometric Criteria for Possible or Probable Memory Impairment Brooks, B.L. (Calgary, Alta./Coquitlam, B.C.); Iverson, G.L. (Coquitlam, B.C./ Vancouver, B.C.); Feldman, H.H. (Vancouver, B.C.); Holdnack, J.A. (San Antonio, Tex.) 451 Visuospatial Ability and Memory Are Associated with Falls Risk in Older People. A Population-Based Study Martin, K.; Thomson, R.; Blizzard, L. (Hobart, Tas.); Wood, A. (Clayton, Vic./Parkville, Vic.); Garry, M. (Hobart, Tas.); Srikanth, V. (Hobart, Tas./Clayton, Vic.) 458 Rapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the APOE ␧4/␧4 Genotype Blom, E.S.; Giedraitis, V. (Uppsala); Zetterberg, H. (Mölndal); Fukumoto, H. (Charlestown, Mass.); Blennow, K. (Mölndal); Hyman, B.T.; Irizarry, M.C. (Charlestown, Mass.); Wahlund, L.-O. (Huddinge); Lannfelt, L.; Ingelsson, M. (Uppsala) 465 Population Variation in Glial Fibrillary Acidic Protein Levels in Brain Ageing: Relationship to Alzheimer-Type Pathology and Dementia Wharton, S.B. (Sheffield); O’Callaghan, J.P. (Morgantown, W.Va.); Savva, G.M. (Cambridge); Nicoll, J.A.R. (Southampton); Matthews, F. (Cambridge); Simpson, J.E.; Forster, G.; Shaw, P.J. (Sheffield); Brayne, C. (Cambridge); Ince, P.G. (Sheffield) on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group 474 Brain Metabolic Correlates of Cerebrospinal Fluid Beta-Amyloid 42 and Tau in Alzheimer’s Disease Vukovich, R.; Perneczky, R.; Drzezga, A.; Förstl, H.; Kurz, A. (München); Riemenschneider, M. (München/Homburg/Saar) 481 Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer’s Disease: The OmegAD Study Freund-Levi, Y.; Hjorth, E.; Lindberg, C. (Stockholm); Cederholm, T. (Uppsala); Faxen-Irving, G.; Vedin, I.; Palmblad, J.; Wahlund, L.-O.; Schultzberg, M. (Stockholm); Basun, H. (Uppsala); Eriksdotter Jönhagen, M. (Stockholm) Contents Dement Geriatr Cogn Disord Vol. 27, 2009 V 534 Diagnostic Evaluation of Dementia in the Secondary Health No. 6 Care Sector Original Research Articles 491 Longitudinal Influences of Partner Depression on Cognitive Functioning in Latino Spousal Pairs Hinton, L.; Hagar, Y.; West, N.; González, H.M.; Mungas, D.; Beckett, L.; Haan, M.N. (Sacramento, Calif.) 501 Color Discrimination Performance in Patients with Alzheimer’s Disease Salamone, G.; Di Lorenzo, C.; Mosti, S.; Lupo, F.; Cravello, L.; Palmer, K. (Rome); Musicco, M. (Rome/Milan); Caltagirone, C. (Rome) 508 A Study on the Association of the Chromosome 12p13 Locus with Sporadic Late-Onset Alzheimer’s Disease in Chinese Li, Y.; Chu, L.W. (Hong Kong); Li, Z. (Guangzhou); Yik, P.-Y.; Song, Y.-Q. (Hong Kong) 513 Genetic Variation of CYP19 (Aromatase) Gene Influences Age at Onset of Alzheimer’s Disease in Women Corbo, R.M. (Rome); Gambina, G. (Verona); Ulizzi, L. (Rome); Moretto, G. (Verona); Scacchi, R. (Rome) 519 Long-Term Statin Therapy and CSF Cholesterol Levels: Implications for Alzheimer’s Disease Evans, B.A.; Evans, J.E.; Baker, S.P.; Kane, K.; Swearer, J. (Worcester, Mass.); Hinerfeld, D. (Bar Harbor, Me.); Caselli, R. (Scottsdale, Ariz.); Rogaeva, E.; St. George-Hyslop, P. (Toronto, Ont.); Moonis, M.; Pollen, D.A. (Worcester, Mass.) 525 Association between ApoE ␧4 and Cognitive Impairment after Phung, T.K.T.; Andersen, B.B.; Kessing, L.V. (Copenhagen); Mortensen, P.B. (Århus); Waldemar, G. (Copenhagen) 543 Pro-Inflammatory Cytokine Genes Influence the Clinical Features of Frontotemporal Lobar Degeneration Rainero, I.; Rubino, E.; Cappa, G.; Rota, E.; Valfrè, W.; Ferrero, P.; Fenoglio, P.; Baci, D.; D’Amico, G.; Vaula, G.; Gallone, S.; Pinessi, L. (Turin) 548 Education, Occupation, and Dementia: The Bavarian School Sisters Study Bickel, H.; Kurz, A. (München) 557 Increased Risk for Falling Associated with Subtle Cognitive Impairment: Secondary Analysis of a Randomized Clinical Trial Gleason, C.E.; Gangnon, R.E.; Fischer, B.L.; Mahoney, J.E. (Madison, Wisc.) 564 Cognitive and Noncognitive Neurological Features of Young-Onset Dementia Kelley, B.J.; Boeve, B.F.; Josephs, K.A. (Rochester, Minn.) 572 Spanish Version of the Bayer Activities of Daily Living Scale in Mild Cognitive Impairment and Mild Alzheimer Disease: Discriminant and Concurrent Validity Sánchez-Benavides, G.; Manero, R.M.; Quiñones-Úbeda, S.; de Sola, S.; Quintana, M.; Peña-Casanova, J. (Barcelona) 579 Association between Plasma Homocysteine Levels and Mortality in Elderly Patients with Mental Illness Nilsson, K.; Gustafson, L.; Hultberg, B. (Lund) Stroke Wagle, J.; Farner, L. (Oslo/Sem); Flekkøy, K.; Wyller, T.B.; Sandvik, L.; Eiklid, K.L.; Fure, B.; Stensrød, B.; Engedal, K. (Oslo) 584 Erratum 585 Acknowledgement to Reviewers 586 Author Index Vol. 27, 2009 589 Subject Index Vol. 27, 2009 VI Dement Geriatr Cogn Disord Vol. 27, 2009 Contents