Adenoid Cystic Carcinoma of Palate-A Difficult Diagnosis

Dental Research Journal, 2013

Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, slow growing, characteristically shows infiltrative growth and perineural invasion. This paper reports a case of Adenoid Cystic Carcinoma in a 35 year old female man reported with a swelling on the left side of palate involving the hard and soft palate since 8 months which was diagnosed histopathologically and review of literature of the peculiar clinical, and histopathological features.

Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, slow growing, characteristically shows infiltrative growth and perineural invasion. This paper reports a case of Adenoid Cystic Carcinoma in a 35 year old female man reported with a swelling on the left side of palate involving the hard and soft palate since 8 months which was diagnosed histopathologically and review of literature of the peculiar clinical, and histopathological features.

International Journal of Medical Science and Current Research , 2020

Adenoid cystic carcinoma (ADCC) is rare malignant tumor of secretory gland. It accounts for 10% of all salivary gland tumors. Minor salivary glands, particularly palate involve in about 75% cases with 25% in major salivary glands mainly the Parotid gland. The tumor is most often clinically deceptive due to its small size and slow growth, which actually overlies its extensive subclinical invasion, multiple recurrence and delayed onset of distant metastasis making the prognosis questionable, aptly referred as "wolf in sheep's clothing." Metastasis is common to regional lymph node, lung, liver and kidney. Wide local excision, with adjuvant radiotherapy, offers the best diagnostic modality. The aim of the present case series is to focus on its clinical presentation and its differential diagnosis.

SRM Journal of Research in Dental Sciences, 2014

tumors is the hard palate, followed by the base of the tongue, [1] whereas the lower lip, retro molar-tonsilar pillar region and sublingual gland are affected less frequently. [2] Other primary sites are breast, lacrimal glands, lung, and prostate. [3] Adenoid cystic carcinoma (ACC) of salivary glands is a rare slow growing malignant tumor, characterized by wide local infiltration and accounts about 1% of all malignant tumors of the oral and maxillofacial region. [4] It is the second most common malignancy to occur in salivary glands, and the most common malignancy found in minor salivary glands. [5] Upto 96% of all salivary gland tumors are malignant, and ACC represents about 30% of them. [1] We hereby present two cases of a malignant salivary gland tumor (one each in the tongue and palate).

BJGP Open, 2017

IOSR Journals , 2019

Adenoid cystic carcinoma (ACC) is the one of the most common malignancy of the salivary gland. It is considered as one of the intermediate grade of salivary gland neoplasms. ACC shows slow growth with high propensity for spread through perineural sheath, local recurrence and distant metastatic deposits involving bones, lung, and liver. Here, reporting a case of ACC in 60 yr male patient involving the left posterolateral part of the hard palate. Taking consideration of clinical presentation, past history of maxillary sinus drainage provisionally it was diagnosed as Mucous retention cyst wrt 24,25,26. The sections under H&E suggested that, it is adenoid cystic carcinoma. The section also shows the infiltration to the adjacent bone.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2002

Adenoid cystic carcinoma is a tumor arising from the minor salivary glands, the palate being the commonest site. It accounts for about 1% of all head and neck malignancies. We report a case with the typical presentation of a palatal growth with extensive intra-cranial invasion. The diagnosis of this case and a brief review of literature is discussed. Final diagnosis of this case was made from cytological reports. The dry smears stained with MGG were found to be definitely superior to the alcohol fixed slides stained with papanicolaou. The aim here is to highlight the importance of cytology in the diagnosis of such tumors.

Acta Scientific Dental Scienecs, 2021

Adenoid cystic carcinoma is regarded as a rare malignant neoplasm of the salivary gland. The clinical as well as pathological features of this neoplasm include slow growth, perineural invasion and the potential for local recurrence. The total incidence rate is about 2-4% of head and neck tumors. It involves palate most commonly among the minor salivary glands, and parotid and submandibular salivary glands among the majors. Here, we describe two cases of adenoid cystic carcinoma involving the parotid salivary gland and the palate regions.

IP Innovative Publication Pvt. Ltd., 2018

Introduction: Adenoid cystic carcinoma (ACC) is a malignant tumor affecting mainly the salivary glands. It can also occur in other sites like breast and skin. It is important to diagnose adenoid cystic carcinoma at its early stage because this tumor is well known for its local recurrence and distant metastasis. This tumor accounts for about 1% of all head and neck malignancies and 6-10% of all salivary gland neoplasms. Adenoid cystic carcinoma occurs in any salivary gland site, but approximately 50-60% develop within minor salivary gland especially palate. The tumor is seen to arise from the pluripotent stem cell which gives rise to ductal epithelial and myoepithelial cells. Three patterns occur in ACC namely cribriform, tubular and solid. The cribriform pattern is the most common form and the solid pattern is the least common. However, in most cases combination of two or more patterns are seen. The solid variant of ACC has significant morphological and immunohistochemical overlap with a large range of tumors including others carcinoma and sarcoma. Case Report: In this study, we describe three cases of oral cavity lesions with different clinical presentations. Histopathological examination was done and a diagnosis was made. Immunohistochemistry was further done to support the diagnosis. Discussion: Solid variant of ACC was diagnosed on histopathological examination of all three cases. Solid variant of ACC may be misinterpreted for many other benign and malignant tumors, in oral cavity, because cribriform pattern which is seen in most cases of ACC is lacking in this variant. These three cases are presented here because of rarity and difficulties in diagnosis of this pattern of ACC exist in microscopic examination. These patients need to be treated with intensive therapy to avoid recurrence and further spread. Keywords: Adenoid cystic carcinoma, Solid variant, Poor prognosis

Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology, 2019

Introduction: Adenoid cystic carcinoma (ACC) is a malignant tumor affecting mainly the salivary glands. It can also occur in other sites like breast and skin. It is important to diagnose adenoid cystic carcinoma at its early stage because this tumor is well known for its local recurrence and distant metastasis. This tumor accounts for about 1% of all head and neck malignancies and 6-10% of all salivary gland neoplasms. Adenoid cystic carcinoma occurs in any salivary gland site, but approximately 50-60% develop within minor salivary gland especially palate. The tumor is seen to arise from the pluripotent stem cell which gives rise to ductal epithelial and myoepithelial cells. Three patterns occur in ACC namely cribriform, tubular and solid. The cribriform pattern is the most common form and the solid pattern is the least common. However, in most cases combination of two or more patterns are seen. The solid variant of ACC has significant morphological and immunohistochemical overlap with a large range of tumors including others carcinoma and sarcoma. Case Report: In this study, we describe three cases of oral cavity lesions with different clinical presentations. Histopathological examination was done and a diagnosis was made. Immunohistochemistry was further done to support the diagnosis. Discussion: Solid variant of ACC was diagnosed on histopathological examination of all three cases. Solid variant of ACC may be misinterpreted for many other benign and malignant tumors, in oral cavity, because cribriform pattern which is seen in most cases of ACC is lacking in this variant. These three cases are presented here because of rarity and difficulties in diagnosis of this pattern of ACC exist in microscopic examination. These patients need to be treated with intensive therapy to avoid recurrence and further spread.