Leiomyosarcoma of Mesentery: A Case Report

Iranian Journal of Medical Sciences, 2017

Mesenteric masses are infrequent lesions ranging from benign cysts to aggressive malignancies and often present a diagnostic and therapeutic challenge. The mesentery is a frequent recipient of metastases from the gastrointestinal tract, pancreas, and biliary cancers. Primary mesenteric tumors are relatively rare, mostly mesenchymal in origin and benign in nature. Examples include gastrointestinal stromal tumors and smooth muscle tumors. We describe a 50-year-old woman, who presented with a lump in the left hypochondrium along with altered bowel habits of 2 years’ duration. Imaging revealed a cystic lesion, raising the differentials of a benign lesion. Exploratory laparotomy revealed a large cystic mass in the mesentery closely abutting the jejunal loops. This was followed by mass resection along with a segment of the jejunum. Histopathological examination revealed features of a leiomyosarcoma. Postoperatively, the patient developed a colocutaneous fistula, which was re-excised. At 6...

Polish Journal of Pathology, 2013

Mesenteric leiomyosarcoma (LMS) is a very rare malignancy whose familiar occurrence has not yet been reported. We present two sisters who developed intestinal LMS. Pathological analysis of the tumor samples, including evaluation of smooth muscle actin+, desmin+, Myf4-, DOG-1-, S100-, CD34-and CD117-confirmed LMS diagnosis. Molecular analysis of the lesions, both primary tumors and a liver metastasis, revealed several genomic imbalances, with recurrent chromosomal aberration: interstitial gain at chromosome 17p11.2-13.1 with the minimal overlapping region of 9.2 Mb. Our study provides further evidence for the significant role of the genes located in this region in the early stage of carcinogenesis.

Egyptian Journal of Radiology and Nuclear Medicine

Background Leiomyosarcoma arising from mesentery is a rare tumor associated with worse prognosis. The tumor arises from smooth muscles in vascular wall. Ileal mesentery is common site of this tumor origin. Case presentation A middle age female was presented with complain of abdominal distension. A mass was palpable on abdominal examination. CT scan showed large mesenteric cyst. 15 × 10 cm large mass excised with associated mesentery and small bowel segment and on histopathology was found, and it was diagnosed as mesenteric leiomyosarcoma. The patient was discharged and referred to oncology for chemotherapy. Conclusion Leiomyosarcoma is a rare disease with grave prognosis. There is a paucity of literature and proper guidelines for its management; however, surgical excision with healthy margins is a mainstay of management. Close follow-up is recommended post-operatively because there are high chances of recurrence and metastasis.

Pan African Medical Journal, 2015

Leiomyosarcoma is a rare tumor of the smooth muscle, but relatively frequent in the stomach and the small intestine. The mesocolic site is rare. Globally, leimyosarcoma represents less than 0, 1% of the malignant tumors found in the colon and the anus. Because of the similarities with other digestive tumors, namely mesenchymatous or benign tumors of the smooth muscle, the diagnosis of a pleomorphic sarcoma remains difficult even at the histological stage. Surgery is the mainstay of the therapy. We report a case of leiomyosarcoma of the mesocolon and discuss about its main characteristics in the view of the current literature about this pathological condition.

Clinical sarcoma research, 2016

Abdominal leiomyosarcoma arising from the mesentery is a rare malignancy. It is an aggressive entity with an overall 5 year survival rate between 20 and 30 %. Surgical resection is the cornerstone of primary treatment and may be curative for localized disease. However, patients often develop intra-abdominal relapse and/or metastatic disease. If surgical resection is not feasible, palliative chemotherapy is the treatment of choice. However, there are no clear guidelines regarding chemotherapy; neither in the adjuvant nor advanced setting. We present a 40 year-old woman, with a mesenteric leiomyosarcoma, who underwent radical tumor resection and did not receive adjuvant oncological therapy. Three months postoperatively, she developed metastatic disease to the lungs and liver. After multidisciplinary assessment she received an unconventional histological-subtype-tailored chemotherapy comprising 3-4 regimens. Initially, there was a decrease both in number and size of metastases. Ultimat...

Molecular and clinical oncology, 2016

Mesenteric leiomyosarcoma is a rare disease with poor prognosis. Previously, mesenteric leiomyosarcoma was not differentiated from gastrointestinal stromal tumor (GIST), which is the most common mesenchymal tumor of the gastrointestinal tract, and several cases of GIST may have been misclassified as mesenteric leiomyosarcoma. Thus, the actual clinicopathological characteristics of mesenteric leiomyosarcomas remain unclear. We herein describe a case of leiomyosarcoma arising in the descending mesocolon in a patient who developed metachronous liver metastasis. A 76-year-old woman reported a mass in her left upper abdomen. Computed tomography imaging revealed a low-density tumor adjacent to the descending colon. The patient underwent surgery and the tumor was resected along with part of the descending colon. Immunohistochemical differential diagnosis revealed that the tumor was positive for smooth muscle actin and desmin, and negative for CD117 (c-KIT) and S-100, which are characterist...

Cureus, 2022

The mesentery constitutes a common location for the metastatic spread of malignant gastrointestinal tumors. Primary mesenteric tumors, on the other hand, are very rare; lymphomas are the most common, followed by benign and malignant mesenchymal tumors. We present a case of a 43-year-old patient operated on for a primary mesenteric leiomyosarcoma with a positive immunostain for DOG1, despite having no KIT or PDGFRa mutations on molecular analysis. Moreover, we review the pertinent literature.

International Surgery Journal, 2021

Mesenteric masses are infrequent lesions ranging from benign cyst to aggressive malignancies and often present as diagnostic and therapeutic challenge. The mesentery is a frequent recipient of metastasis from the gastrointestinal tract, pancreas, and biliary cancers. Primary mesenteric tumours are relatively rare, mostly mesenchymal in origin and benign in nature. Examples include gastrointestinal stromal tumours and smooth muscle tumours. Pleomorphic leiomyosarcoma of mesocolon is extremely rare with a reported incidence of 1:350,000. So accurate preoperative diagnosis of mesenteric soft tissue tumours is generally difficult. It accounts for less than 1% of the malignant tumours found in colon. Leiomyosarcoma is a malignant tumour arising from smooth cell lineage. These tumours occur most commonly in middle aged individuals. We describe a case of pleomorphic leiomyosarcoma arising from the colonic mesentery in a 27-year-old male patient, with massive lower gastrointestinal bleed (L...

Informes De La Construcción, 76(574), 6656., 2024

The construction of gunpowder stores in Spain (XVIII - XIX) is a faithful reflection of the construction mechanics of the Illustration in the different domains of the Hispanic monarchy developed by military engineers. The morphological and typological classification of the projects kept in the Spanish archives allows a chronological reading of the powder magazines, and at the same time makes it possible to understand the evolution of these constructions. In conclusion, it is established that the peak of these projects was between 1715-1755 using bomb-proof barrel vaults. From this date onwards, structurally simpler models of masonry with wooden structures were imposed, changing the concept of the strength of the vaults for a strategy of increasing the protective enclosures, and moving the gunpowder stores away from the fortified squares. La construcción de almacenes de pólvora en la España de los siglos XVIII-XIX es un fiel reflejo de la mecánica constructiva de la Ilustración en los diferentes dominios de la Monarquía Hispánica, desarrollada por los ingenieros militares. La clasificación morfológica y tipológica de 271 proyectos de almacenes, custodiados en diferentes archivos españoles, nos permite una lectura cronológica de tales edificios adecuada para entender su evolución. Dentro de la gran variedad de modelos existentes puede establecerse el momento álgido en la realización de estos trabajos entre 1715-1755, en virtud de la utilización de bóvedas de cañón a prueba de bomba. A partir de estas fechas se imponen ejemplos de obras de fábrica con estructuras de madera más sencillas, hasta el punto de sacrificar el concepto de la resistencia de las bóvedas por la estrategia de aumentar los recintos de protección de los almacenes y alejarlos fuera de las plazas fortificadas.

This study examines the expectations, benefits and challenges of adoption of International Public Sector Accounting Standards (IPSAS) in Nigeria. The objective of this study is to determine the benefits, expectations and the challenges that Nigeria will face in her quest to adopt IPSAS. This study is based on data obtained from literature survey and archival sources in the context of IPSAS adoption in Nigeria. Content analysis was used to analyze the relevant literatures. It was observed that adoption of IPSAS is expected to increase the level of accountability, transparency, comparability and international best practices in public sector of Nigeria. Also, it was discovered that adoption of IPSAS based standards will provide more meaningful information for decision makers and improve the quality of the financial reporting system in Nigeria. Hence, the study concludes that the adoption of IPSAS in Nigeria is expected to impact operating procedures, reporting practices thereby strengthening good governance and relations with the government and the governed. The study recommends that the government should provide the legal framework for proper and effective implementation of IPSAS accrual basis of accounting in Nigeria. Efforts should be made to enshrine the requirements of IPSAS accrual basis into the appropriate regulatory systems such as the constitution of the Federal Republic of Nigeria and the Financial Regulations and public sector accounting staff should be properly trained on IPSAS.