Flow-mediated vasodilation (FMD) of the brachial artery is a noninvasive tool used for endothelia... more Flow-mediated vasodilation (FMD) of the brachial artery is a noninvasive tool used for endothelial function evaluation. There is increasing evidence that endothelial dysfunction is a common etiological factor for erectile dysfunction (ED) and cardiovascular events. To evaluate endothelial function with a high-resolution ultrasound device, to assess FMD in men diagnosed with ED and without clinical evidence of significant atherosclerotic disease, classified as "intermediate risk" according to the Framingham risk score (FRS). This is a case-control study that included 52 consecutive men. In all men with ED evaluated by a score less than 22 on International Index of Erectile Function-5 questionnaire (IIEF-5), clinical parameters such as blood pressure, waist circumference, hip circumference, body mass index, lipid profile, fasting glucose, and serum total testosterone were obtained. These parameters were compared with those men without diagnosis of ED (IIEF-5 score≥22) (age-matched, also classified as "intermediate risk" according to the FRS). All underwent brachial artery ultrasound for assessment of FMD, as a noninvasive method to evaluate endothelial function. Statistical analysis was performed considering a P<0.05. Endothelium-dependent FMD was evaluated in the right brachial artery with a high-resolution ultrasound machine following reactive hyperemia. Thirty-four men were included in the ED group, and 18 were included in the group without ED. The mean ages were 59.61±9.87 and 56.18±10.93, respectively (P=0.27). Clinical and laboratory evaluations were similar between men with and without ED (P>0.05) except for waist circumference that was greater in patients with ED (mean=100.85 cm vs. 96.05; P<0.05). The percentage of FMD was higher in men without ED when compared with those with ED (mean FMD 11.33±6.08% vs. 4.24±7.06%, respectively; P=0.001). Men without established atherosclerotic disease presenting with ED demonstrated a worse endothelial function.
Introduction: Nitric oxide (NO), synthesized from L-arginine by the enzyme nitric oxide synthase ... more Introduction: Nitric oxide (NO), synthesized from L-arginine by the enzyme nitric oxide synthase (NOS), seems to play an ambiguous role during tissue ischemia-reperfusion injury. Our objective was to evaluate the effects of L-arginine, a NO donor, and N -nitro-L-arginine-methylester (L-NAME), a NOS inhibitor, on oxidative stress, renal dysfunction, histologic alterations and G surgical mortality rate induced by renal ischemia-reperfusion (RIR) in uninephrectomized rats. Materials and methods: Onehundred and ninety-seven Wistar rats were randomized into five experimental groups. Group 1: sham operation; group 2: right uninephrectomy (UNI); group 3: UNIqRIR in the contralateral kidney; group 4: UNIqL-NAME (20 mgykg; intraperitoneally)q RIR; and group 5: UNIqL-arginineqRIR. The effect of the drugs was evaluated by lipid peroxidation measured by the renal malondialdehyde (MD) content and chemiluminescence (CL) levels, serum creatinine (Cr) levels, urinary volume, tubular necrosis and athrophy, inflammatory infiltrate, interstitial fibrosis as histologic evaluation and surgical mortality rate after the procedures. A P value less than 0.05 was considered significant. Results: Right uninephrectomy did not alter the renal parameters. RIR increased Cr levels (at 24 and 96 h of reperfusion), index of lipid peroxidation (both MD and QL levels), and worsened the histologic aspects. Pretreatment with L-arginine reduced the kidney levels of QL when compared with the non-treated group (5574"909 vs. 13 660"1104 cpsymg of protein; P-0.05) but increased the MD levels (0.97"0.24 vs. 0.79"0.06 nmolymg of protein; P-0.05). Moreover, L-arginine attenuated the increment of Cr levels, inflammatory infiltrate and tubular athrophy in rats subjected to RIR (P-0.05). On the other hand, pretreatment with L-NAME increased both CL (17 482"4397 vs. 13 660"1104 cpsymg of protein; P-0.05) and MD levels (1.16"0.11 vs. 0.79"0.06 nmolymg of protein; P-0.05). Furthermore, L-NAME worsened the renal dysfunction (P-0.05) at 192 h after the RIR, and surgical mortality rates were similar (P)0.05). Conclusion: L-arginine has a tendency to exert a beneficial effect on renal damage during RIR in rats. Moreover, L-NAME seems to worsen the renal damage by increasing the kidney-levels of CL and impairment of renal function probably due to reduction of NO production. ᮊ
Purpose: There is a growing body of evidence in the literature correlating erectile dysfunction t... more Purpose: There is a growing body of evidence in the literature correlating erectile dysfunction to obesity. We investigated the correlation of different anthropometric indexes of central obesity to erectile dysfunction. Materials and Methods: A cross-sectional study was performed including 256 consecutive men 40 years old or older. All men completed the International Index of Erectile Function, and were evaluated routinely with a clinical history, physical examination and blood analysis for fasting serum glucose, lipid profile and serum testosterone. Anthropometric measures included body mass index, waist circumference, sagittal abdominal diameter, maximal abdominal circumference, and waist-hip, waist-thigh, waist-height, sagittal abdominal diameter-thigh and sagittal abdominal diameter-height indexes. Results: In men 40 to 60 years old the different anthropometric indexes of central obesity were not correlated with the presence of erectile dysfunction (p Ͼ0.05). Men older than 60 years (41%, range 61 to 81) demonstrated an association among erectile dysfunction and waist-hip index (p ϭ 0.04), waist-thigh index (p ϭ 0.02), sagittal abdominal diameter (p ϭ 0.03), sagittal abdominal diameter-height index (p ϭ 0.02) and maximal abdominal circumference (p ϭ 0.04). After logistic regression analysis an independent effect on the presence of erectile dysfunction was observed for waist-hip index (OR 8.56, 95% CI 1.44 -50.73), sagittal abdominal diameter (OR 7.87, 95% CI 1.24 -49.75), sagittal abdominal diameter-height index (OR 14.21, 95% CI 1.11-182.32), maximum abdominal circumference (OR 11.72, 95% CI 1.73-79.18) and waist circumference (OR 19.37, 95% CI 1.15-326.55). Conclusions: This study suggests that central obesity, assessed by several anthropometric indicators, is associated to the presence of erectile dysfunction in men older than 60 years. Sagittal abdominal diameter, sagittal abdominal diameter-height index, maximum abdominal circumference, waist circumference and waist-hip index were useful indicators to predict the presence of erectile dysfunction.
To investigate the relationship between lower urinary tract symptoms (LUTS) and erectile dysfunct... more To investigate the relationship between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED), while considering multiple risk factors for ED, including an anthropometric evaluation of central obesity.
Hypogonadism is a clinical and biochemical syndrome associated with a range of disease states tha... more Hypogonadism is a clinical and biochemical syndrome associated with a range of disease states that has significant effects on morbidity and mortality and also affects quality of life. Because of the increase in life expectancy and prostate carcinoma (PCa) survival, a significant increase in the number of men with hypogonadism who have undergone presumably curative treatment of PCa is anticipated. Despite the widespread belief regarding contraindication of testosterone administration to men with known or suspected PCa, there is no convincing evidence that the normalization of testosterone serum levels in men with low levels presents a deleterious effect on the evolution of the disease. In the few available case series describing testosterone replacement therapy (TRT) after treatment of PCa, no case of clinical or biochemical progression was observed. The available data suggest that TRT can be cautiously considered in selected hypogonadal men previously treated for curative intent of low-risk PCa and without evidence of active disease.
The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfuncti... more The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia -reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia -reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia -reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemiareperfusion in uninephrectomized rats. D
... Ernani Luís Rhoden 2 Marcelo Mauri 3 Leonardo Petteffi 4 Francisco Dacanal 3 Marco Pilla 3 Ad... more ... Ernani Luís Rhoden 2 Marcelo Mauri 3 Leonardo Petteffi 4 Francisco Dacanal 3 Marco Pilla 3 Adriane Belló-Klein 5 Cláudio ... mesmos procedimentos realizados no Grupo 2. Entretanto, foi permitida a reperfusão sanguínea arterial por um período de 1 hora, ao final da qual o ...
To evaluated the effects of L-arginine (a NO donor) and L-NAME (Nw-nitro-L-arginine methyl ester ... more To evaluated the effects of L-arginine (a NO donor) and L-NAME (Nw-nitro-L-arginine methyl ester - a NOS inhibitor) on ischemia-reperfusion in rat livers. One hundred fifty two male Wistar rats were divided into four groups: control (simulated surgery); hepatic IR; pretreatment with L-arginine plus hepatic IR; and L-NAME plus hepatic IR. The hepatocellular damage was evaluated at the first, third and seventh days after the procedures through the alanine-aminotransferase (ALT) and aspartate-aminotransaminase (AST) levels, as well as histopathological features: vascular congestion (VC); steatosis (STE); necrosis (NEC); and inflammatory infiltration (INF). The mortality rate was also evaluated. The pretreatment with L-NAME significantly worsened the AST levels after hepatic IR (p<0.05) at first day and L-arginine demonstrated an attenuating effect on ALT levels at seventh day (p<0.05). Furthermore, the administration of L-arginine was able to reduce the VC and STE in the seventh day after hepatic IR (p<0.05). The analysis of the mortality rates did not demonstrate any difference between the groups. Nevertheless, there was not effect of L-arginine and L-NAME on the mortality of the animals. L-arginine/NO pathway has a role in the hepatic IR because the pretreatment with L-arginine partially had attenuated the hepatocellular damage induced by hepatic IR in rats.
Journal of long-term effects of medical implants, 2003
The past several years have witnessed a veritable revolution in our understanding and management ... more The past several years have witnessed a veritable revolution in our understanding and management of erectile dysfunction. Although surgical implants in the form of penile prostheses continue to be an important part of treatment of end-stage cases, the largest change has been brought about by the introduction of oral medications, such as sildenafil (Viagra). This review addresses the etiology, epidemiology, diagnosis, and treatment of erectile dysfunction in light of the remarkable advances in the field.
Despite the growing interest in cystic neoplasms of the pancreas, their diagnosis, treatment and ... more Despite the growing interest in cystic neoplasms of the pancreas, their diagnosis, treatment and prognosis are still obscure and controversial. We studied, from September 1989 to July 1999, 21 patients (18 women) with an average age of 54.3 years who were submitted to surgical treatment for cystic neoplasms of the pancreas. Ultrasonography and computed tomography were performed in all patients. The treatment performed was surgical resection: cephalic gastroduodenopancreatectomy, 4 patients; body and tail pancreatectomy, 11 patients; only tail pancreatectomy, 2 patients; and two other patients were submitted to enucleation of one small lesion in the head of the pancreas. Internal drainage, through cystogastrostomy or cystojejunostomy, was performed in 3 cases. Site of tumor: body and tail region, 14 cases; head of the pancreas, 7 cases. Three patients had postoperative complications (respiratory tract infection, surgical wound infection, abdominal abscess). Three patients developed d...
The present study was undertaken to determine whether colchicine has a beneficial effect in the p... more The present study was undertaken to determine whether colchicine has a beneficial effect in the prevention of hepatic cirrhosis when it is given simultaneously with CCl4. Wistar rats were employed as experimental animals and divided into 6 groups: Group I received saline solution, Group II, saline solution and mineral oil; Group III, colchicine (10 micrograms/100 g) and mineral oil; Group IV, colchicine (10 micrograms/100 g) and CCl4; Group V, colchicine (5 micrograms/100 g) and CCl4; and, Group VI received saline solution and CCl4. The effect of colchicine was evaluated by liver function tests, serum total proteins, electrolytes and histological evaluation. The results demonstrated higher values of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin in groups IV and V when compared with group VI (p < 0.05). No difference between group VI and groups IV and V was observed in histological evaluation, serum total proteins and electrolytes (...
ObjectivesTo determine the prevalence of prostate cancer in hypogonadal men with a prostate-speci... more ObjectivesTo determine the prevalence of prostate cancer in hypogonadal men with a prostate-specific antigen (PSA) level of 4.0 ng/mL or less.
PurposeWe evaluated the effects of chronic administration of dehydroepiandrosterone (DHEA) on ser... more PurposeWe evaluated the effects of chronic administration of dehydroepiandrosterone (DHEA) on serum total testosterone and DHEA sulfate (DHEAS), prostatic weight and histological features in the rat.
SOUTO CAV et al. Urethral catheter removal 7 or 14 days after radical retropubic prostatectomy: c... more SOUTO CAV et al. Urethral catheter removal 7 or 14 days after radical retropubic prostatectomy: clinical implications and complications in a randomized study. Rev. Hosp. Clin. Fac. Med. S.Paulo 59(5):262-265, 2004.
PURPOSE:: We tested the hypothesis that early catheter removal may be accomplished safely after r... more PURPOSE:: We tested the hypothesis that early catheter removal may be accomplished safely after radical prostatectomy. MATERIALS AND METHODS:: Cystography on postoperative day 4 or 5 in 42 of 67 consecutive patients who underwent radical ...
International braz j urol : official journal of the Brazilian Society of Urology
Evaluate the ability of serum concentration of prostate specific antigen (PSA) between 2 cutting ... more Evaluate the ability of serum concentration of prostate specific antigen (PSA) between 2 cutting points to predict the existence of bone metastasis confirmed by bone scintigraphy in man with prostate cancer. Two hundred and fourteen consecutive patients with prostate cancer were evaluated during the present study in the period from 1998 to 2001. From all patients, PSA serum concentrations and bone scintigraphy were obtained. For the study, 2 cutting points of PSA (10 and 20 ng/mL) were adopted to predict the existence of bone metastasis. From the 214 patients, 35 (16.3 x 0025;) presented positive scintigraphic examinations for the presence of bone metastasis. No patient presented bone metastasis in scintigraphy if having PSA < 10 ng/mL, and in only 1 patient (0.46 x 0025;) with bone metastasis PSA concentration was < 20 ng/mL. Therefore, when the cutting point adopted for PSA serum concentration was 10 ng/mL, a negative predictive value for bone metastasis was 100 x 0025; with...
Flow-mediated vasodilation (FMD) of the brachial artery is a noninvasive tool used for endothelia... more Flow-mediated vasodilation (FMD) of the brachial artery is a noninvasive tool used for endothelial function evaluation. There is increasing evidence that endothelial dysfunction is a common etiological factor for erectile dysfunction (ED) and cardiovascular events. To evaluate endothelial function with a high-resolution ultrasound device, to assess FMD in men diagnosed with ED and without clinical evidence of significant atherosclerotic disease, classified as &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;intermediate risk&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; according to the Framingham risk score (FRS). This is a case-control study that included 52 consecutive men. In all men with ED evaluated by a score less than 22 on International Index of Erectile Function-5 questionnaire (IIEF-5), clinical parameters such as blood pressure, waist circumference, hip circumference, body mass index, lipid profile, fasting glucose, and serum total testosterone were obtained. These parameters were compared with those men without diagnosis of ED (IIEF-5 score≥22) (age-matched, also classified as &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;intermediate risk&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; according to the FRS). All underwent brachial artery ultrasound for assessment of FMD, as a noninvasive method to evaluate endothelial function. Statistical analysis was performed considering a P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05. Endothelium-dependent FMD was evaluated in the right brachial artery with a high-resolution ultrasound machine following reactive hyperemia. Thirty-four men were included in the ED group, and 18 were included in the group without ED. The mean ages were 59.61±9.87 and 56.18±10.93, respectively (P=0.27). Clinical and laboratory evaluations were similar between men with and without ED (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05) except for waist circumference that was greater in patients with ED (mean=100.85 cm vs. 96.05; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). The percentage of FMD was higher in men without ED when compared with those with ED (mean FMD 11.33±6.08% vs. 4.24±7.06%, respectively; P=0.001). Men without established atherosclerotic disease presenting with ED demonstrated a worse endothelial function.
Introduction: Nitric oxide (NO), synthesized from L-arginine by the enzyme nitric oxide synthase ... more Introduction: Nitric oxide (NO), synthesized from L-arginine by the enzyme nitric oxide synthase (NOS), seems to play an ambiguous role during tissue ischemia-reperfusion injury. Our objective was to evaluate the effects of L-arginine, a NO donor, and N -nitro-L-arginine-methylester (L-NAME), a NOS inhibitor, on oxidative stress, renal dysfunction, histologic alterations and G surgical mortality rate induced by renal ischemia-reperfusion (RIR) in uninephrectomized rats. Materials and methods: Onehundred and ninety-seven Wistar rats were randomized into five experimental groups. Group 1: sham operation; group 2: right uninephrectomy (UNI); group 3: UNIqRIR in the contralateral kidney; group 4: UNIqL-NAME (20 mgykg; intraperitoneally)q RIR; and group 5: UNIqL-arginineqRIR. The effect of the drugs was evaluated by lipid peroxidation measured by the renal malondialdehyde (MD) content and chemiluminescence (CL) levels, serum creatinine (Cr) levels, urinary volume, tubular necrosis and athrophy, inflammatory infiltrate, interstitial fibrosis as histologic evaluation and surgical mortality rate after the procedures. A P value less than 0.05 was considered significant. Results: Right uninephrectomy did not alter the renal parameters. RIR increased Cr levels (at 24 and 96 h of reperfusion), index of lipid peroxidation (both MD and QL levels), and worsened the histologic aspects. Pretreatment with L-arginine reduced the kidney levels of QL when compared with the non-treated group (5574"909 vs. 13 660"1104 cpsymg of protein; P-0.05) but increased the MD levels (0.97"0.24 vs. 0.79"0.06 nmolymg of protein; P-0.05). Moreover, L-arginine attenuated the increment of Cr levels, inflammatory infiltrate and tubular athrophy in rats subjected to RIR (P-0.05). On the other hand, pretreatment with L-NAME increased both CL (17 482"4397 vs. 13 660"1104 cpsymg of protein; P-0.05) and MD levels (1.16"0.11 vs. 0.79"0.06 nmolymg of protein; P-0.05). Furthermore, L-NAME worsened the renal dysfunction (P-0.05) at 192 h after the RIR, and surgical mortality rates were similar (P)0.05). Conclusion: L-arginine has a tendency to exert a beneficial effect on renal damage during RIR in rats. Moreover, L-NAME seems to worsen the renal damage by increasing the kidney-levels of CL and impairment of renal function probably due to reduction of NO production. ᮊ
Purpose: There is a growing body of evidence in the literature correlating erectile dysfunction t... more Purpose: There is a growing body of evidence in the literature correlating erectile dysfunction to obesity. We investigated the correlation of different anthropometric indexes of central obesity to erectile dysfunction. Materials and Methods: A cross-sectional study was performed including 256 consecutive men 40 years old or older. All men completed the International Index of Erectile Function, and were evaluated routinely with a clinical history, physical examination and blood analysis for fasting serum glucose, lipid profile and serum testosterone. Anthropometric measures included body mass index, waist circumference, sagittal abdominal diameter, maximal abdominal circumference, and waist-hip, waist-thigh, waist-height, sagittal abdominal diameter-thigh and sagittal abdominal diameter-height indexes. Results: In men 40 to 60 years old the different anthropometric indexes of central obesity were not correlated with the presence of erectile dysfunction (p Ͼ0.05). Men older than 60 years (41%, range 61 to 81) demonstrated an association among erectile dysfunction and waist-hip index (p ϭ 0.04), waist-thigh index (p ϭ 0.02), sagittal abdominal diameter (p ϭ 0.03), sagittal abdominal diameter-height index (p ϭ 0.02) and maximal abdominal circumference (p ϭ 0.04). After logistic regression analysis an independent effect on the presence of erectile dysfunction was observed for waist-hip index (OR 8.56, 95% CI 1.44 -50.73), sagittal abdominal diameter (OR 7.87, 95% CI 1.24 -49.75), sagittal abdominal diameter-height index (OR 14.21, 95% CI 1.11-182.32), maximum abdominal circumference (OR 11.72, 95% CI 1.73-79.18) and waist circumference (OR 19.37, 95% CI 1.15-326.55). Conclusions: This study suggests that central obesity, assessed by several anthropometric indicators, is associated to the presence of erectile dysfunction in men older than 60 years. Sagittal abdominal diameter, sagittal abdominal diameter-height index, maximum abdominal circumference, waist circumference and waist-hip index were useful indicators to predict the presence of erectile dysfunction.
To investigate the relationship between lower urinary tract symptoms (LUTS) and erectile dysfunct... more To investigate the relationship between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED), while considering multiple risk factors for ED, including an anthropometric evaluation of central obesity.
Hypogonadism is a clinical and biochemical syndrome associated with a range of disease states tha... more Hypogonadism is a clinical and biochemical syndrome associated with a range of disease states that has significant effects on morbidity and mortality and also affects quality of life. Because of the increase in life expectancy and prostate carcinoma (PCa) survival, a significant increase in the number of men with hypogonadism who have undergone presumably curative treatment of PCa is anticipated. Despite the widespread belief regarding contraindication of testosterone administration to men with known or suspected PCa, there is no convincing evidence that the normalization of testosterone serum levels in men with low levels presents a deleterious effect on the evolution of the disease. In the few available case series describing testosterone replacement therapy (TRT) after treatment of PCa, no case of clinical or biochemical progression was observed. The available data suggest that TRT can be cautiously considered in selected hypogonadal men previously treated for curative intent of low-risk PCa and without evidence of active disease.
The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfuncti... more The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia -reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia -reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia -reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemiareperfusion in uninephrectomized rats. D
... Ernani Luís Rhoden 2 Marcelo Mauri 3 Leonardo Petteffi 4 Francisco Dacanal 3 Marco Pilla 3 Ad... more ... Ernani Luís Rhoden 2 Marcelo Mauri 3 Leonardo Petteffi 4 Francisco Dacanal 3 Marco Pilla 3 Adriane Belló-Klein 5 Cláudio ... mesmos procedimentos realizados no Grupo 2. Entretanto, foi permitida a reperfusão sanguínea arterial por um período de 1 hora, ao final da qual o ...
To evaluated the effects of L-arginine (a NO donor) and L-NAME (Nw-nitro-L-arginine methyl ester ... more To evaluated the effects of L-arginine (a NO donor) and L-NAME (Nw-nitro-L-arginine methyl ester - a NOS inhibitor) on ischemia-reperfusion in rat livers. One hundred fifty two male Wistar rats were divided into four groups: control (simulated surgery); hepatic IR; pretreatment with L-arginine plus hepatic IR; and L-NAME plus hepatic IR. The hepatocellular damage was evaluated at the first, third and seventh days after the procedures through the alanine-aminotransferase (ALT) and aspartate-aminotransaminase (AST) levels, as well as histopathological features: vascular congestion (VC); steatosis (STE); necrosis (NEC); and inflammatory infiltration (INF). The mortality rate was also evaluated. The pretreatment with L-NAME significantly worsened the AST levels after hepatic IR (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) at first day and L-arginine demonstrated an attenuating effect on ALT levels at seventh day (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). Furthermore, the administration of L-arginine was able to reduce the VC and STE in the seventh day after hepatic IR (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). The analysis of the mortality rates did not demonstrate any difference between the groups. Nevertheless, there was not effect of L-arginine and L-NAME on the mortality of the animals. L-arginine/NO pathway has a role in the hepatic IR because the pretreatment with L-arginine partially had attenuated the hepatocellular damage induced by hepatic IR in rats.
Journal of long-term effects of medical implants, 2003
The past several years have witnessed a veritable revolution in our understanding and management ... more The past several years have witnessed a veritable revolution in our understanding and management of erectile dysfunction. Although surgical implants in the form of penile prostheses continue to be an important part of treatment of end-stage cases, the largest change has been brought about by the introduction of oral medications, such as sildenafil (Viagra). This review addresses the etiology, epidemiology, diagnosis, and treatment of erectile dysfunction in light of the remarkable advances in the field.
Despite the growing interest in cystic neoplasms of the pancreas, their diagnosis, treatment and ... more Despite the growing interest in cystic neoplasms of the pancreas, their diagnosis, treatment and prognosis are still obscure and controversial. We studied, from September 1989 to July 1999, 21 patients (18 women) with an average age of 54.3 years who were submitted to surgical treatment for cystic neoplasms of the pancreas. Ultrasonography and computed tomography were performed in all patients. The treatment performed was surgical resection: cephalic gastroduodenopancreatectomy, 4 patients; body and tail pancreatectomy, 11 patients; only tail pancreatectomy, 2 patients; and two other patients were submitted to enucleation of one small lesion in the head of the pancreas. Internal drainage, through cystogastrostomy or cystojejunostomy, was performed in 3 cases. Site of tumor: body and tail region, 14 cases; head of the pancreas, 7 cases. Three patients had postoperative complications (respiratory tract infection, surgical wound infection, abdominal abscess). Three patients developed d...
The present study was undertaken to determine whether colchicine has a beneficial effect in the p... more The present study was undertaken to determine whether colchicine has a beneficial effect in the prevention of hepatic cirrhosis when it is given simultaneously with CCl4. Wistar rats were employed as experimental animals and divided into 6 groups: Group I received saline solution, Group II, saline solution and mineral oil; Group III, colchicine (10 micrograms/100 g) and mineral oil; Group IV, colchicine (10 micrograms/100 g) and CCl4; Group V, colchicine (5 micrograms/100 g) and CCl4; and, Group VI received saline solution and CCl4. The effect of colchicine was evaluated by liver function tests, serum total proteins, electrolytes and histological evaluation. The results demonstrated higher values of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin in groups IV and V when compared with group VI (p < 0.05). No difference between group VI and groups IV and V was observed in histological evaluation, serum total proteins and electrolytes (...
ObjectivesTo determine the prevalence of prostate cancer in hypogonadal men with a prostate-speci... more ObjectivesTo determine the prevalence of prostate cancer in hypogonadal men with a prostate-specific antigen (PSA) level of 4.0 ng/mL or less.
PurposeWe evaluated the effects of chronic administration of dehydroepiandrosterone (DHEA) on ser... more PurposeWe evaluated the effects of chronic administration of dehydroepiandrosterone (DHEA) on serum total testosterone and DHEA sulfate (DHEAS), prostatic weight and histological features in the rat.
SOUTO CAV et al. Urethral catheter removal 7 or 14 days after radical retropubic prostatectomy: c... more SOUTO CAV et al. Urethral catheter removal 7 or 14 days after radical retropubic prostatectomy: clinical implications and complications in a randomized study. Rev. Hosp. Clin. Fac. Med. S.Paulo 59(5):262-265, 2004.
PURPOSE:: We tested the hypothesis that early catheter removal may be accomplished safely after r... more PURPOSE:: We tested the hypothesis that early catheter removal may be accomplished safely after radical prostatectomy. MATERIALS AND METHODS:: Cystography on postoperative day 4 or 5 in 42 of 67 consecutive patients who underwent radical ...
International braz j urol : official journal of the Brazilian Society of Urology
Evaluate the ability of serum concentration of prostate specific antigen (PSA) between 2 cutting ... more Evaluate the ability of serum concentration of prostate specific antigen (PSA) between 2 cutting points to predict the existence of bone metastasis confirmed by bone scintigraphy in man with prostate cancer. Two hundred and fourteen consecutive patients with prostate cancer were evaluated during the present study in the period from 1998 to 2001. From all patients, PSA serum concentrations and bone scintigraphy were obtained. For the study, 2 cutting points of PSA (10 and 20 ng/mL) were adopted to predict the existence of bone metastasis. From the 214 patients, 35 (16.3 x 0025;) presented positive scintigraphic examinations for the presence of bone metastasis. No patient presented bone metastasis in scintigraphy if having PSA < 10 ng/mL, and in only 1 patient (0.46 x 0025;) with bone metastasis PSA concentration was < 20 ng/mL. Therefore, when the cutting point adopted for PSA serum concentration was 10 ng/mL, a negative predictive value for bone metastasis was 100 x 0025; with...
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Papers by Ernani Rhoden