DNA sensing by the cGAS-STING pathway in health and disease (Q92267263)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

review article

1 reference

title

DNA sensing by the cGAS-STING pathway in health and disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

author name string

Mona Motwani

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

Scott Pesiridis

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

Katherine A Fitzgerald

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

publication date

29 July 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

published in

Nature Reviews Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

page(s)

657-674

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

28 April 2020

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STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.

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7 January 2021

Structural mechanism of cytosolic DNA sensing by cGAS

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

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7 January 2021

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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7 January 2021

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

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7 January 2021

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

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7 January 2021

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance

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7 January 2021

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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7 January 2021

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

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7 January 2021

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

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7 January 2021

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

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7 January 2021

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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7 January 2021

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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7 January 2021

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

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7 January 2021

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

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7 January 2021

STING is a direct innate immune sensor of cyclic di-GMP

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7 January 2021

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

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7 January 2021

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.

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https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

1 reference

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7 January 2021

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.

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7 January 2021

The Ca sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

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https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

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7 January 2021

Activation of STING requires palmitoylation at the Golgi.

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7 January 2021

Intracellular DNA recognition

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7 January 2021

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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7 January 2021

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter

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7 January 2021

Interferon-stimulated genes: a complex web of host defenses

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7 January 2021

Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1

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7 January 2021

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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7 January 2021

NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.

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7 January 2021

Activation of STAT6 by STING is critical for antiviral innate immunity

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7 January 2021

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

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7 January 2021

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

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7 January 2021

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Zika virus infection activates sting-dependent antiviral autophagy in the Drosophila brain

1 reference

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7 January 2021

Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain

1 reference

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7 January 2021

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Signalling strength determines proapoptotic functions of STING.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Dengue virus activates cGAS through the release of mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-dependent translation inhibition restricts RNA virus replication.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Intracellular Nucleic Acid Detection in Autoimmunity.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS Micro-Manages Genotoxic Stress

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Innate immunity: Nuclear waste ignites cGAS

1 reference

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7 January 2021

Innate immunity and tolerance toward mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

1 reference

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7 January 2021

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

1 reference

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7 January 2021

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

1 reference

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7 January 2021

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

G3BP1 promotes DNA binding and activation of cGAS

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Aicardi-Goutières syndrome and the type I interferonopathies

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Trex1 prevents cell-intrinsic initiation of autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Human disease phenotypes associated with mutations in TREX1.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Immune Diseases Associated with TREX1 and STING Dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Type I interferon-mediated autoinflammation due to DNase II deficiency

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING manifests self DNA-dependent inflammatory disease

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Mutation of DNASE1 in people with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Features of systemic lupus erythematosus in Dnase1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Activated STING in a vascular and pulmonary syndrome

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Stimulator of Interferon Genes-Associated Vasculopathy With Onset in Infancy: A Mimic of Childhood Granulomatosis With Polyangiitis

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Failure to thrive, interstitial lung disease, and progressive digital necrosis with onset in infancy

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Severe Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation).

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-associated vasculopathy develops independently of IRF3 in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-associated lung disease in mice relies on T cells but not type I interferon

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

IRF3 and type I interferons fuel a fatal response to myocardial infarction.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Parkin and PINK1 mitigate STING-induced inflammation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Chromosomal instability drives metastasis through a cytosolic DNA response

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

DNA breaks and chromosome pulverization from errors in mitosis

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Mitotic progression following DNA damage enables pattern recognition within micronuclei.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS surveillance of micronuclei links genome instability to innate immunity

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Fate of micronuclei and micronucleated cells

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Impaired nuclear functions in micronuclei results in genome instability and chromothripsis.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS is essential for cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Emergence of micronuclei and their effects on the fate of cells under replication stress

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Type I interferon response and innate immune sensing of cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Rationally combining immunotherapies to improve efficacy of immune checkpoint blockade in solid tumors

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Combination cancer immunotherapy and new immunomodulatory targets

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Rationale for stimulator of interferon genes-targeted cancer immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Established T Cell-Inflamed Tumors Rejected after Adaptive Resistance Was Reversed by Combination STING Activation and PD-1 Pathway Blockade.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS is essential for the antitumor effect of immune checkpoint blockade

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Design of amidobenzimidazole STING receptor agonists with systemic activity

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Sublingual targeting of STING with 3'3'-cGAMP promotes systemic and mucosal immunity against anthrax toxins.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

A new adjuvant delivery system 'cyclic di-GMP/YSK05 liposome' for cancer immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Natural STING Agonist as an "Ideal" Adjuvant for Cutaneous Vaccination.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING agonists induce an innate antiviral immune response against hepatitis B virus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Rare variants in the TREX1 gene and susceptibility to autoimmune diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Typing TREX1 gene in patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

cGAS in action: Expanding roles in immunity and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cyclic di-GMP sensing via the innate immune signaling protein STING

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The Type I Interferonopathies.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

DNase II: genes, enzymes and function

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

UBXN3B positively regulates STING-mediated antiviral immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Ubiquitination of STING at lysine 224 controls IRF3 activation.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

USP13 negatively regulates antiviral responses by deubiquitinating STING

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

Familial chilblain lupus due to a gain-of-function mutation in STING.

1 reference

https://api.crossref.org/works/10.1038%2FS41576-019-0151-1

7 January 2021

10.1038/S41576-019-0151-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358977%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

1 reference