DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization (Q33773787)

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English	DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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based on heuristic

inferred from title

bites and stings

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based on heuristic

inferred from title

author name string

Charlene M Downey

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Mehrnoosh Aghaei

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Reto A Schwendener

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

Frank R Jirik

4

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Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

18 June 2014

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

PubMed publication ID

29 July 2017

9

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Europe PubMed Central

PubMed publication ID

29 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

e99988

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

copyright license

Creative Commons Attribution 4.0 International

18 June 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants

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STING-dependent cytosolic DNA sensing pathways

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Anticancer flavonoids are mouse-selective STING agonists.

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28 July 2018

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

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Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

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STING is a direct innate immune sensor of cyclic di-GMP

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4062468

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Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

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Mouse models of advanced spontaneous metastasis for experimental therapeutics

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Temporal aspects of the action of ASA404 (vadimezan; DMXAA)

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28 July 2018

Acute vascular disruption by 5,6-dimethylxanthenone-4-acetic Acid in an orthotopic model of human head and neck cancer

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

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Neutrophil influx and chemokine production during the early phases of the antitumor response to the vascular disrupting agent DMXAA (ASA404)

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Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer

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28 July 2018

"Re-educating" tumor-associated macrophages by targeting NF-kappaB.

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The history of the angiogenic switch concept

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p38 mitogen-activated protein kinase is required for the antitumor activity of the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.

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Identifiers

10.1371/JOURNAL.PONE.0099988

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Europe PubMed Central

PubMed publication ID

29 July 2017

2014PLoSO...999988D

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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