Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases (Q90187449)

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12 April 2020

review article

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9 October 2022

Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases (English)

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12 April 2020

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9 October 2022

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lysophospholipids

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sphingosine

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sphingosine 1-phosphate receptor

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6

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12 April 2020

author name string

Lincheng Zhang

1

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12 April 2020

Yutong Dong

2

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12 April 2020

Yiran Wang

3

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12 April 2020

Wenhui Hu

4

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12 April 2020

Shiwu Dong

5

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12 April 2020

publication date

10 March 2020

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Journal of Cellular and Molecular Medicine

12 April 2020

1 April 2020

1 reference

9 October 2022

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32155312%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

9 October 2022

Creative Commons Attribution

1 reference

9 October 2022

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells

1 reference

12 December 2020

Sphingosine-phosphate lyase

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12 December 2020

Activation of mitogen‐activated protein kinase is involved in sphingosine 1‐phosphate‐stimulated interleukin‐6 synthesis in osteoblasts

1 reference

12 December 2020

Identification of the First Mammalian Sphingosine Phosphate Lyase Gene and Its Functional Expression in Yeast

1 reference

12 December 2020

Calcium signals and calcium channels in osteoblastic cells

1 reference

12 December 2020

Changes in sphingolipid levels induced by epidermal growth factor in osteoblastic cells. Effects of these metabolites on cytosolic calcium levels

1 reference

12 December 2020

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

1 reference

12 December 2020

Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells.

1 reference

12 December 2020

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors.

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12 December 2020

Lysophospholipid regulation of mononuclear phagocytes

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12 December 2020

The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase

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12 December 2020

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

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12 December 2020

Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate

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12 December 2020

RANKL Regulates Fas Expression and Fas-Mediated Apoptosis in Osteoclasts

1 reference

12 December 2020

The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration

1 reference

12 December 2020

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

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12 December 2020

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

1 reference

12 December 2020

Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling

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12 December 2020

Deafness and stria vascularis defects in S1P2 receptor-null mice.

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12 December 2020

Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.

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12 December 2020

Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages

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12 December 2020

Adverse effects of bisphosphonates: current issues.

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12 December 2020

Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages

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12 December 2020

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal

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12 December 2020

Osteoclast-osteoblast communication

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12 December 2020

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.

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12 December 2020

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

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12 December 2020

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

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12 December 2020

Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.

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12 December 2020

Calcium signaling in osteoclasts

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12 December 2020

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

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12 December 2020

Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis

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12 December 2020

Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

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12 December 2020

Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass

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12 December 2020

Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.

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12 December 2020

Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

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12 December 2020

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

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12 December 2020

The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages

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12 December 2020

Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation

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12 December 2020

Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis

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12 December 2020

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

1 reference

12 December 2020

Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P₃ receptor and Cdc42.

1 reference

12 December 2020

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways

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12 December 2020

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

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12 December 2020

Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D.

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12 December 2020

Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines

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12 December 2020

Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells

1 reference

12 December 2020

Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model

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12 December 2020

Osteoporosis and fracture risk in older people

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12 December 2020

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.

1 reference

12 December 2020

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

1 reference

12 December 2020

Evaluation of osseous metastasis in bone scintigraphy

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12 December 2020

K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling

1 reference

12 December 2020

The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient

1 reference

12 December 2020

Exit Strategies: S1P Signaling and T Cell Migration

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12 December 2020

Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases

1 reference

12 December 2020

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential

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12 December 2020

Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity

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12 December 2020

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

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12 December 2020

Fingolimod suppresses bone resorption in female patients with multiple sclerosis

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12 December 2020

Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts

1 reference

12 December 2020

The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway

1 reference

12 December 2020

Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment

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12 December 2020

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

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12 December 2020

Romosozumab for the treatment of osteoporosis

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12 December 2020

Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1.

1 reference

12 December 2020

Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration.

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12 December 2020

Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential

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12 December 2020

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

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12 December 2020

Fas/S1P1 crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis

1 reference

12 December 2020

Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair.

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12 December 2020

Increased sphingosine-1-phosphate production in response to osteocyte mechanotransduction

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12 December 2020

RANKL-induced M1 macrophages are involved in bone formation

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12 December 2020

Estrogen Deficiency-Mediated M2 Macrophage Osteoclastogenesis Contributes to M1/M2 Ratio Alteration in Ovariectomized Osteoporotic Mice

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12 December 2020

SPHK1-S1PR1-RANKL axis regulates the interactions between macrophages and BMSCs in inflammatory bone loss

1 reference

12 December 2020

Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming

1 reference

12 December 2020

Effects of an oral bisphosphonate and three intravenous bisphosphonates on several cell types in vitro

1 reference

12 December 2020

Sphingosine-1-phosphate receptor 1 mediates elevated IL-6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease.

1 reference

12 December 2020

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

1 reference

12 December 2020

Inhibitory effect of vanillin on RANKL-induced osteoclast formation and function through activating mitochondrial-dependent apoptosis signaling pathway

1 reference

12 December 2020

Sphingosine-1-Phosphate Modulates the Effect of Estrogen in Human Osteoblasts

1 reference

12 December 2020

Sphingosine 1-Phosphate (S1P)/S1P Receptor2/3 Axis Promotes Inflammatory M1 Polarization of Bone Marrow-Derived Monocyte/Macrophage via G(α)i/o/PI3K/JNK Pathway

1 reference

12 December 2020

Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells

1 reference

12 December 2020

Where Have All the T Cells Gone?

1 reference

12 December 2020

The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability

1 reference

12 December 2020

Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies

1 reference

12 December 2020

S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway

1 reference

12 December 2020

Sphingosine-1-Phosphate Receptor 2 Controls Podosome Components Induced by RANKL Affecting Osteoclastogenesis and Bone Resorption

1 reference

12 December 2020

Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis

1 reference

12 December 2020

Pro-Inflammatory Role of S1P3 in Macrophages

1 reference

12 December 2020

The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

1 reference

12 December 2020

S1P-S1PR1 Signaling: the "Sphinx" in Osteoimmunology

1 reference

12 December 2020

The role of sphingosine 1-phosphate metabolism in bone and joint pathologies and ectopic calcification

1 reference

12 December 2020