Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease (Q89470931)

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5 April 2020

review article

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title

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease (English)

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5 April 2020

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3

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5 April 2020

author name string

Tosha Williams

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1

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5 April 2020

David R Borchelt

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2

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5 April 2020

publication date

31 January 2020

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Molecular Neurodegeneration

5 April 2020

published in

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5 April 2020

volume

15

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5 April 2020

issue

1

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5 April 2020

page(s)

8

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

5 April 2020

cites work

1 reference

12 December 2020

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation

1 reference

12 December 2020

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1 reference

12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

12 December 2020

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site

1 reference

12 December 2020

Distribution and characterization of the serum lipoproteins and apoproteins in the mouse, Mus musculus

1 reference

12 December 2020

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

1 reference

12 December 2020

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

12 December 2020

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

1 reference

12 December 2020

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

12 December 2020

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

12 December 2020

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

1 reference

12 December 2020

Apolipoprotein E alleles as risk factors in Alzheimer's disease

1 reference

12 December 2020

Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele

1 reference

12 December 2020

A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele

1 reference

12 December 2020

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1 reference

12 December 2020

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 reference

12 December 2020

Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

1 reference

12 December 2020

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2

1 reference

12 December 2020

Apo E structure determines VLDL clearance and atherosclerosis risk in mice.

1 reference

12 December 2020

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

1 reference

12 December 2020

Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging

1 reference

12 December 2020

Apolipoprotein E: far more than a lipid transport protein

1 reference

12 December 2020

ApoE deficiency compromises the blood brain barrier especially after injury.

1 reference

12 December 2020

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

1 reference

12 December 2020

Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide

1 reference

12 December 2020

1 reference

12 December 2020

The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

1 reference

12 December 2020

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

1 reference

12 December 2020

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

1 reference

12 December 2020

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

1 reference

12 December 2020

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

1 reference

12 December 2020

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

1 reference

12 December 2020

Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?

1 reference

12 December 2020

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior

1 reference

12 December 2020

Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.

1 reference

12 December 2020

Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis

1 reference

12 December 2020

Effect of domain interaction on apolipoprotein E levels in mouse brain.

1 reference

12 December 2020

Risk of dementia in diabetes mellitus: a systematic review

1 reference

12 December 2020

Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

1 reference

12 December 2020

Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.

1 reference

12 December 2020

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E epsilon4 allele frequency in vascular dementia.

1 reference

12 December 2020

Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

1 reference

12 December 2020

Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease

1 reference

12 December 2020

An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction

1 reference

12 December 2020

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

1 reference

12 December 2020

APOE genotype-specific differences in the innate immune response

1 reference

12 December 2020

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

1 reference

12 December 2020

A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.

1 reference

12 December 2020

The impact of voluntary exercise on mental health in rodents: a neuroplasticity perspective

1 reference

12 December 2020

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

1 reference

12 December 2020

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

1 reference

12 December 2020

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

1 reference

12 December 2020

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

1 reference

12 December 2020

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

1 reference

12 December 2020

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.

1 reference

12 December 2020

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

1 reference

12 December 2020

Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease

1 reference

12 December 2020

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

1 reference

12 December 2020

Accumulation of intraneuronal Abeta correlates with ApoE4 genotype

1 reference

12 December 2020

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

1 reference

12 December 2020

ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

1 reference

12 December 2020

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

1 reference

12 December 2020

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

1 reference

12 December 2020

Update on CETP inhibition

1 reference

12 December 2020

Exercise training increases size of hippocampus and improves memory

1 reference

12 December 2020

Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

1 reference

12 December 2020

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

1 reference

12 December 2020

Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects

1 reference

12 December 2020

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

1 reference

12 December 2020

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

1 reference

12 December 2020

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

1 reference

12 December 2020

Therapeutic Potential for HDAC Inhibitors in the Heart

1 reference

12 December 2020

Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

1 reference

12 December 2020

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis

1 reference

12 December 2020

APOE genotype alters glial activation and loss of synaptic markers in mice

1 reference

12 December 2020

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

1 reference

12 December 2020

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

12 December 2020

APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics

1 reference

12 December 2020

Animal models of atherosclerosis

1 reference

12 December 2020

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

1 reference

12 December 2020

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice

1 reference

12 December 2020

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

1 reference

12 December 2020

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

1 reference

12 December 2020

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS

1 reference

12 December 2020

Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice

1 reference

12 December 2020

Insulin and Alzheimer's disease: untangling the web.

1 reference

12 December 2020

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice

1 reference

12 December 2020

Linking epigenetics to lipid metabolism: focus on histone deacetylases.

1 reference

12 December 2020

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

1 reference

12 December 2020

Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging

1 reference

12 December 2020

RNA-guided human genome engineering via Cas9

1 reference

12 December 2020

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

1 reference

12 December 2020

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

1 reference

12 December 2020

APOE ε4 increases risk for dementia in pure synucleinopathies

1 reference

12 December 2020

Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration

1 reference

12 December 2020

Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease.

1 reference

12 December 2020

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

1 reference

12 December 2020

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

1 reference

12 December 2020

Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

1 reference

12 December 2020

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

1 reference

12 December 2020

Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease

1 reference

12 December 2020

Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial

1 reference

12 December 2020

APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis

1 reference

12 December 2020

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown

1 reference

12 December 2020

Ketone bodies as signaling metabolites.

1 reference

12 December 2020

Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis

1 reference

12 December 2020

Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain

1 reference

12 December 2020

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

1 reference

12 December 2020

Dysbetalipoproteinaemia: a mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E.

1 reference

12 December 2020

ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

1 reference

12 December 2020

Heritable multiplex genetic engineering in rats using CRISPR/Cas9.

1 reference

12 December 2020

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls

1 reference

12 December 2020

Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial

1 reference

12 December 2020

Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis

1 reference

12 December 2020

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

1 reference

12 December 2020

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.

1 reference

12 December 2020

Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: a review

1 reference

12 December 2020

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function

1 reference

12 December 2020

Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice.

1 reference

12 December 2020

Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice

1 reference

12 December 2020

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

1 reference

12 December 2020

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.

1 reference

12 December 2020

Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists

1 reference

12 December 2020

Genetics of Vascular Dementia: Systematic Review and Meta-Analysis

1 reference

12 December 2020

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

1 reference

12 December 2020

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

1 reference

12 December 2020

Long Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia

1 reference

12 December 2020

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

1 reference

12 December 2020

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected].

1 reference

12 December 2020

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

1 reference

12 December 2020

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease

1 reference

12 December 2020

Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks

1 reference

12 December 2020

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

1 reference

12 December 2020

Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.

1 reference

12 December 2020

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

1 reference

12 December 2020

microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

1 reference

12 December 2020

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease

1 reference

12 December 2020

APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article.

1 reference

12 December 2020

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease

1 reference

12 December 2020

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice

1 reference

12 December 2020

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

1 reference

12 December 2020

The Role of APOE in the Occurrence of Frontotemporal Dementia in Amyotrophic Lateral Sclerosis

1 reference

12 December 2020

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

1 reference

12 December 2020

ApoE2 and Alzheimer's disease: time to take a closer look

1 reference

12 December 2020

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.

1 reference

12 December 2020

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

1 reference

12 December 2020

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.

1 reference

12 December 2020

Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid.

1 reference

12 December 2020

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies.

1 reference

12 December 2020

Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage

1 reference

12 December 2020

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins

1 reference

12 December 2020

Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis

1 reference

12 December 2020

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

1 reference

12 December 2020

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

1 reference

12 December 2020

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

1 reference

12 December 2020

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review

1 reference

12 December 2020

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

1 reference

12 December 2020

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

1 reference

12 December 2020

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

1 reference

12 December 2020

The role of APOE on lipid homeostasis and inflammation in normal brains

1 reference

12 December 2020

APOE Genotype Effects on Intrinsic Brain Network Connectivity in Patients with Amnestic Mild Cognitive Impairment

1 reference

12 December 2020

Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling

1 reference

12 December 2020

Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.

1 reference

12 December 2020

Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia

1 reference

12 December 2020

Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model

1 reference

12 December 2020

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

1 reference

12 December 2020

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

1 reference

12 December 2020

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism

1 reference

12 December 2020

Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015.

1 reference

12 December 2020

CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels

1 reference

12 December 2020

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

1 reference

12 December 2020

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

1 reference

12 December 2020

Apolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features

1 reference

12 December 2020

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

1 reference

12 December 2020

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

1 reference

12 December 2020

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

1 reference

12 December 2020

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

1 reference

12 December 2020

Alzheimer's disease: A matter of blood-brain barrier dysfunction?

1 reference

12 December 2020

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

1 reference

12 December 2020

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

1 reference

12 December 2020

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

1 reference

12 December 2020

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.

1 reference

12 December 2020

ApoE4 Accelerates Early Seeding of Amyloid Pathology

1 reference

12 December 2020

Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial

1 reference

12 December 2020

AAVrh.10-mediated APOE2 CNS Gene Therapy for APOE4-associated Alzheimer's Disease

1 reference

12 December 2020

A transcriptomic atlas of aged human microglia.

1 reference

12 December 2020

Systematic review of the efficacy of statins for the treatment of Alzheimer's disease.

1 reference

12 December 2020

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats

1 reference

12 December 2020

Cell-specific production, secretion, and function of apolipoprotein E.

1 reference

12 December 2020

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

1 reference

12 December 2020

Histone deacetylase-mediated regulation of endolysosomal pH.

1 reference

12 December 2020

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.

1 reference

12 December 2020

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

1 reference

12 December 2020

Targeting the accomplice to thwart the culprit: a new target for the prevention of amyloid deposition.

1 reference

12 December 2020

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.

1 reference

12 December 2020

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice.

1 reference

12 December 2020

Metabolic syndrome marks early risk for cognitive decline with APOE4 gene variation: A case study

1 reference

12 December 2020

Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2

1 reference

12 December 2020

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

1 reference

12 December 2020

CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response

1 reference

12 December 2020

Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area.

1 reference

12 December 2020

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH.

1 reference

12 December 2020

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types

1 reference

12 December 2020

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

1 reference

12 December 2020

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

1 reference

12 December 2020

High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia

1 reference

12 December 2020

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

1 reference

12 December 2020

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model

1 reference

12 December 2020

High-affinity interactions and signal transduction between Aβ oligomers and TREM2

1 reference

12 December 2020

APOE ε2 is associated with increased tau pathology in primary tauopathy

1 reference

12 December 2020

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

1 reference

12 December 2020

Effects of Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

1 reference

12 December 2020

Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH.

1 reference

12 December 2020

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line

1 reference

12 December 2020

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

1 reference

12 December 2020

Assessment of APOE in atypical parkinsonism syndromes

1 reference

12 December 2020

Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease

1 reference

12 December 2020

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

1 reference

12 December 2020

Harnessing Immunoproteostasis to Treat Neurodegenerative Disorders

1 reference

12 December 2020

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model

1 reference

12 December 2020

Patients with Alzheimer's disease who carry the ε4 allele benefit more from physical exercise

1 reference

12 December 2020

Antisense oligonucleotides: A primer

1 reference

12 December 2020

A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition

1 reference

12 December 2020

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

1 reference

12 December 2020

Alzheimer's disease drug development pipeline: 2019

1 reference

12 December 2020

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

1 reference

12 December 2020

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

1 reference

12 December 2020

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

1 reference

12 December 2020

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

1 reference

12 December 2020

10.1186/S13024-020-0358-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32005122%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32005122%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

PubMed publication ID

32005122

1 reference