Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper (Q83200613)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19151748%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

review article

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title

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper (English)

1 reference

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20 January 2020

author name string

Ed Palmer

series ordinal

1

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20 January 2020

Dieter Naeher

series ordinal

2

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20 January 2020

publication date

1 March 2009

1 reference

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Nature Reviews Immunology

20 January 2020

published in

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20 January 2020

volume

9

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20 January 2020

issue

3

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20 January 2020

page(s)

207-213

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Quality control in self/nonself discrimination

20 January 2020

cites work

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The thymus selects the useful, neglects the useless and destroys the harmful

31 March 2020

1 reference

Positive and negative selection of T cells

31 March 2020

1 reference

Signaling life and death in the thymus: timing is everything

31 March 2020

1 reference

Selecting and maintaining a diverse T-cell repertoire

31 March 2020

1 reference

Molecular mechanisms for adaptive tolerance and other T cell anergy models

31 March 2020

1 reference

Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

31 March 2020

1 reference

Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity

31 March 2020

1 reference

Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR

31 March 2020

1 reference

A Murine T Cell Receptor Gene Complex: Isolation, Structure and Rearrangement

31 March 2020

1 reference

Induction of MHC-restricted specificity and tolerance in the thymus

31 March 2020

1 reference

A kinetic differentiation model for the action of altered TCR ligands.

31 March 2020

1 reference

Understanding specificity and sensitivity of T-cell recognition.

31 March 2020

1 reference

Modulation of T cell function by TCR/pMHC binding kinetics

31 March 2020

1 reference

Quantitative challenges in understanding ligand discrimination by alphabeta T cells

31 March 2020

1 reference

A minimal level of MHC class II expression is sufficient to abrogate autoreactivity

31 March 2020

1 reference

Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation

31 March 2020

1 reference

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

31 March 2020

1 reference

T-cell-receptor affinity and thymocyte positive selection

31 March 2020

1 reference

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

31 March 2020

1 reference

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

31 March 2020

1 reference

A constant affinity threshold for T cell tolerance

31 March 2020

1 reference

T cell receptor antagonist peptides induce positive selection

31 March 2020

1 reference

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

31 March 2020

1 reference

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

31 March 2020

1 reference

T cell positive selection by a high density, low affinity ligand

31 March 2020

1 reference

Role of TCR-restricting MHC density and thymic environment on selection and survival of cells expressing low-affinity T cell receptors

31 March 2020

1 reference

Role of self-peptides in positively selecting the T-cell repertoire

31 March 2020

1 reference

The quantity of TCR signal determines positive selection and lineage commitment of T cells

31 March 2020

1 reference

Quantitative impact of thymic clonal deletion on the T cell repertoire

31 March 2020

1 reference

A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection

31 March 2020

1 reference

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

31 March 2020

1 reference

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

31 March 2020

1 reference

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

31 March 2020

1 reference

Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

1 reference

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

31 March 2020

1 reference

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

31 March 2020

1 reference

A kinetic window constricts the T cell receptor repertoire in the thymus.

31 March 2020

1 reference

Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.

31 March 2020

1 reference

Kinetic discrimination in T-cell activation

31 March 2020

1 reference

Partial signaling by CD8+ T cells in response to antagonist ligands

31 March 2020

1 reference

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

31 March 2020

1 reference

A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

31 March 2020

1 reference

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

31 March 2020

1 reference

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

31 March 2020

1 reference

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

31 March 2020

1 reference

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

31 March 2020

1 reference

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

31 March 2020

1 reference

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

31 March 2020

1 reference

The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation

31 March 2020

1 reference

A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation

31 March 2020

1 reference

Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor

31 March 2020

1 reference

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

31 March 2020

1 reference

Roles for glycosylation of cell surface receptors involved in cellular immune recognition

31 March 2020

1 reference

A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change

31 March 2020

1 reference

Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

31 March 2020

1 reference

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

31 March 2020

1 reference

miR-181a is an intrinsic modulator of T cell sensitivity and selection

31 March 2020

1 reference

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

31 March 2020

1 reference

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

31 March 2020

1 reference

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

31 March 2020

1 reference

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

31 March 2020

1 reference

The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function

31 March 2020

1 reference

Ligands for the T-cell receptor: hard times for avidity models

31 March 2020

1 reference

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

31 March 2020

1 reference

Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

31 March 2020

1 reference

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

31 March 2020

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Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

31 March 2020

1 reference

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

31 March 2020

1 reference

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

31 March 2020

1 reference

A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness.

31 March 2020

1 reference

A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

31 March 2020

1 reference

CD3 delta establishes a functional link between the T cell receptor and CD8

31 March 2020

1 reference

Positive selection through a motif in the alphabeta T cell receptor

31 March 2020

1 reference

Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes

31 March 2020

1 reference

Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement

31 March 2020

1 reference

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

31 March 2020

1 reference

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

31 March 2020

1 reference

CD8 lineage commitment in the absence of CD8.

31 March 2020

1 reference

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

31 March 2020

1 reference

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

31 March 2020

1 reference

Photoaffinity labeling of the T cell receptor on cloned cytotoxic T lymphocytes by covalent photoreactive ligand

31 March 2020

1 reference

12 December 2020

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen

1 reference

12 December 2020

Negative selection of T cells occurs throughout thymic development

1 reference

12 December 2020

T cell activation results in physical modification of the mouse CD8 beta chain

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI2469

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19151748%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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