A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change (Q34873201)

5 August 2017

title

A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change (English)

1 reference

5 August 2017

Diana Gil

1

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5 August 2017

Adam G Schrum

series ordinal

2

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5 August 2017

Mark A Daniels

series ordinal

3

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5 August 2017

Ed Palmer

series ordinal

4

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5 August 2017

language of work or name

English

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publication date

1 March 2008

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5 August 2017

published in

Journal of Immunology

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5 August 2017

volume

180

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5 August 2017

issue

6

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5 August 2017

page(s)

3900-3909

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miR-181a is an intrinsic modulator of T cell sensitivity and selection

5 August 2017

cites work

1 reference

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

8 July 2018

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Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

8 July 2018

1 reference

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A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection

8 July 2018

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How TCRs bind MHCs, peptides, and coreceptors

8 July 2018

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CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

8 July 2018

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Central tolerance: learning self-control in the thymus

8 July 2018

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Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses

8 July 2018

1 reference

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T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

8 July 2018

1 reference

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A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection

8 July 2018

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Negative selection--clearing out the bad apples from the T-cell repertoire

8 July 2018

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A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

8 July 2018

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Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

8 July 2018

1 reference

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Positive and negative selection of T cells

8 July 2018

1 reference

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Sweet 'n' sour: the impact of differential glycosylation on T cell responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

A novel CD8-independent high-avidity cytotoxic T-lymphocyte response directed against an epitope in the phosphoprotein of the paramyxovirus simian virus 5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Identification of CD8 as a peanut agglutinin (PNA) receptor molecule on immature thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Kinetic discrimination in T-cell activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Role of CD4 and CD8 in T cell activation and differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Coupling of T-cell activation with T-cell receptor assembly.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Selecting the T cell receptor repertoire

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Kinetic proofreading in T-cell receptor signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Developmental alterations in thymocyte sensitivity are actively regulated by MHC class II expression in the thymic medulla

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Alteration of cell surface sialylation regulates antigen-induced naive CD8+ T cell responses

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Developmental regulation of TCR efficiency

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287409

The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development

9 December 2018

1 reference

12 December 2020

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

1 reference

12 December 2020

A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex

1 reference

12 December 2020

T-cell receptor binding kinetics in T-cell development and activation

1 reference

12 December 2020

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

12 December 2020

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

1 reference

12 December 2020

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1 reference

12 December 2020

CD8-dependent CTL require co-engagement of CD8 and the TCR for phosphatidylinositol hydrolysis, but CD8-independent CTL do not and can kill in the absence of phosphatidylinositol hydrolysis

1 reference

12 December 2020

CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics

1 reference

12 December 2020

A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo

1 reference

12 December 2020

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

12 December 2020

10.4049/JIMMUNOL.180.6.3900

Identifiers

DOI

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5 August 2017

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5 August 2017

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