Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt (Q80148220)

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scientific article published on 11 April 2007

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English	Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt	scientific article published on 11 April 2007

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29 December 2019

Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt (English)

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29 December 2019

type 2 diabetes

1 reference

based on heuristic

inferred from title

left ventricular hypertrophy

1 reference

based on heuristic

inferred from title

2

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29 December 2019

Catherine Rucker-Martin

5

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29 December 2019

author name string

A Darmellah

1

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29 December 2019

F Prunier

3

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29 December 2019

S Tamareille

4

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29 December 2019

D Feuvray

6

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29 December 2019

publication date

11 April 2007

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29 December 2019

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29 December 2019

50

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29 December 2019

6

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29 December 2019

1335-1344

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29 December 2019

Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of intracellular pH in the diabetic myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac consequences of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes-induced vascular hypertrophy is accompanied by activation of Na(+)-H(+) exchange and prevented by Na(+)-H(+) exchange inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double heterozygosity for mutations in the beta-myosin heavy chain and in the cardiac myosin binding protein C genes in a family with hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expanding family of eucaryotic Na(+)/H(+) exchangers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H11 kinase is a novel mediator of myocardial hypertrophy in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maximal coronary flow reserve and metabolic coronary vasodilation in patients with diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ERK pathway regulates Na(+)-HCO(3)(-) cotransport activity in adult rat cardiomyocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Na(+)-H+ antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular dysfunction in insulin-dependent and non-insulin-dependent animal models of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dedifferentiation of atrial myocytes during atrial fibrillation: role of fibroblast proliferation in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial cell death in human diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+) exchanger

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase-mediated regulation of the Na(+)/H(+) exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of diabetes on cardiac structure and function: the strong heart study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of mitogen-activated protein kinases and protein kinase C in alpha(1A)-adrenoceptor-mediated stimulation of the sarcolemmal Na(+)-H(+) exchanger

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular pH and role of Na+/H+ exchange during ischaemia and reperfusion of normal and diabetic rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of coronary microvascular dilation in response to cold pressor--induced sympathetic stimulation in type 2 diabetic patients with abnormal stress thallium imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse mode of the Na+-Ca2+ exchange after myocardial stretch: underlying mechanism of the slow force response

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation by pH0 and intracellular Ca2+ of Na(+)-H+ exchange in diabetic rat isolated ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NHE-1 inhibition: from protection during acute ischaemia/reperfusion to prevention/reversal of myocardial remodelling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17429605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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