Novel Therapeutic Potentials of Taxifolin for Amyloid-β-associated Neurodegenerative Diseases and Other Diseases: Recent Advances and Future Perspectives. (Q64991552)

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scientific article published on 30 April 2019

Novel Therapeutic Potentials of Taxifolin for Amyloid-β-associated Neurodegenerative Diseases and Other Diseases: Recent Advances and Future Perspectives

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English	Novel Therapeutic Potentials of Taxifolin for Amyloid-β-associated Neurodegenerative Diseases and Other Diseases: Recent Advances and Future Perspectives.	scientific article published on 30 April 2019	Novel Therapeutic Potentials of Taxifolin for Amyloid-β-associated Neurodegenerative Diseases and Other Diseases: Recent Advances and Future Perspectives

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24 April 2020

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19 July 2021

Novel Therapeutic Potentials of Taxifolin for Amyloid-β-associated Neurodegenerative Diseases and Other Diseases: Recent Advances and Future Perspectives (English)

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24 April 2020

Alzheimer's disease

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28 October 2020

non-steroidal anti-inflammatory drug

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28 October 2020

cerebral amyloid angiopathy

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6 February 2021

anti-inflammatory agent

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19 July 2021

5

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24 April 2020

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24 April 2020

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Satoshi Saito

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24 April 2020

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Takayuki Inoue

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Noriko Satoh-Asahara

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Masashi Tanaka

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Masafumi Ihara

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International Journal of Molecular Sciences

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toxicity and metabolism of dihydroquercetin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of dementia in diabetes mellitus: a systematic review

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid, blood vessels, and brain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-n oligomers as therapeutic targets of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose tolerance status and risk of dementia in the community: the Hisayama study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic kidney disease, cognitive decline, and incident dementia: the 3C Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimating cerebral microinfarct burden from autopsy samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased number of microinfarcts in Alzheimer disease at 7-T MR imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Janus kinase 3 activity is necessary for phosphorylation of cytosolic phospholipase A2 and prostaglandin E2 synthesis by macrophages infected with Francisella tularensis live vaccine strain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Outcome markers for clinical trials in cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral amyloid angiopathy: emerging concepts

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does the difference between PART and Alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol).

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BMI and risk of dementia in two million people over two decades: a retrospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild Cognitive Impairment: At the Crossroad of Neurodegeneration and Vascular Dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP-Inhibits Cytoplasmic Phospholipase A₂ and Protects Neurons against Amyloid-β-Induced Synapse Damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n).

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-Amyloid in CSF: Biomarker for preclinical cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterozygous knockout of cytosolic phospholipase A2α attenuates Alzheimer's disease pathology in APP/PS1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes: The diabetic brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albuminuria Increases the Risks for Both Alzheimer Disease and Vascular Dementia in Community-Dwelling Japanese Elderly: The Hisayama Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of Lacunar Infarcts in Asians With Intracerebral Hemorrhage: A Magnetic Resonance Imaging and Amyloid Positron Emission Tomography Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxifolin attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Key Residues for the Formation of Aβ42 Amyloid Fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxifolin prevents postprandial hyperglycemia by regulating the activity of α-amylase: Evidence from an in vivo and in silico studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated compounds from Cuscuta pedicellata ameliorate oxidative stress and upregulate expression of some energy regulatory genes in high fat diet induced obesity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-Term Survival and Function After Stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31052203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS20092139

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31052203%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

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Europe PubMed Central

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24 April 2020

PubMed publication ID

1 reference

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24 April 2020

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