Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues (Q30432271)

18 August 2017

Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues (English)

1 reference

18 August 2017

9

Kazuhiro Irie

1 reference

18 August 2017

Mizuho Sato

1

1 reference

18 August 2017

Kazuma Murakami

2

1 reference

18 August 2017

Mayumi Uno

3

1 reference

18 August 2017

Yu Nakagawa

4

1 reference

18 August 2017

Sumie Katayama

5

1 reference

18 August 2017

Ken-ichi Akagi

6

1 reference

18 August 2017

Yuichi Masuda

7

1 reference

18 August 2017

Kiyonori Takegoshi

8

1 reference

18 August 2017

language of work or name

English

0 references

publication date

21 June 2013

1 reference

Journal of Biological Chemistry

18 August 2017

1 reference

18 August 2017

288

1 reference

18 August 2017

32

1 reference

18 August 2017

23212-23224

1 reference

Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Hydrophobicity and conformational change as mechanistic determinants for nonspecific modulators of amyloid β self-assembly

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Dihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1-42) oligomers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Structurally distinct toxicity inhibitors bind at common loci on β-amyloid fibril

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Current therapeutic targets for the treatment of Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Elderberry flavonoids bind to and prevent H1N1 infection in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Stereospecific high-performance liquid chromatography of taxifolin, applications in pharmacokinetics, and determination in tu fu ling (Rhizoma smilacis glabrae) and apple (Malus x domestica).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Amyloid beta-protein assembly and Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Cytotoxic constituents from the bark of Salix hulteni

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Benefits from dietary polyphenols for brain aging and Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Oxidative stress and neurotoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Amyloid plaque core protein in Alzheimer disease and Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

The role of 2,4,5-trihydroxyphenylalanine in melanin biosynthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Drugs: A tangled web of targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Methylation of dihydroquercetin acetates: synthesis of 5-O-methyldihydroquercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Theory of covariance nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Covariance NMR spectroscopy by singular value decomposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Identification of physiological and toxic conformations in Abeta42 aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Catechol derivatives inhibit the fibril formation of amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.464222

Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743493

Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine

26 November 2018

1 reference

12 December 2020

Solid phase peptide synthesis of 15N-gramicidins A, B, and C and high performance liquid chromatographic purification

1 reference

12 December 2020

Comparative pharmacokinetics of silipide and silymarin in rats

1 reference

12 December 2020

Kinetic analysis of amyloid fibril formation

1 reference

12 December 2020

The toxicity and metabolism of dihydroquercetin

1 reference

12 December 2020

Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils

1 reference

12 December 2020

Chemical studies on the constituents of Polygonum nodosum.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1248/CPB.30.1602

Identifiers

DOI

10.1074/JBC.M113.464222

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

23792961

1 reference