Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy (Q64093978)

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scientific article published on 14 March 2019

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English	Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy	scientific article published on 14 March 2019

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scholarly article

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29 April 2020

Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy (English)

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29 April 2020

pharmacokinetics

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corrigendum / erratum

Correction to: Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy

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29 April 2020

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Hang-Ping Yao

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29 April 2020

Liang Feng

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29 April 2020

Sreedhar Reddy Suthe

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29 April 2020

Ling-Hui Chen

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29 April 2020

Tian-Hao Weng

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29 April 2020

Chen-Yu Hu

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29 April 2020

Eun Sung Jun

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29 April 2020

Zhi-Gang Wu

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29 April 2020

Wei-Lin Wang

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29 April 2020

Song Cheol Kim

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29 April 2020

Xiang-Min Tong

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29 April 2020

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14 March 2019

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29 April 2020

Journal for Immunotherapy of Cancer

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29 April 2020

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29 April 2020

1

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29 April 2020

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29 April 2020

copyright license

Creative Commons Attribution 4.0 International

14 March 2019

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April 2022 Public Data File from Crossref

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0 references

A novel putative receptor protein tyrosine kinase of the met family

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the RON gene in human breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of pancreatic cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MET receptor tyrosine kinase in invasion and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering therapeutic monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RON receptor tyrosine kinase as a target for delivery of chemodrugs by antibody directed pathway for cancer cell cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody (mAb)-induced down-regulation of RON receptor tyrosine kinase diminishes tumorigenic activities of colon cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained expression of the RON receptor tyrosine kinase by pancreatic cancer stem cells as a potential targeting moiety for antibody-directed chemotherapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of RON in small and non-small cell lung cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic variant RON160 expression in breast cancer and its potential as a therapeutic target by small molecule tyrosine kinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MSP-RON signalling in cancer: pathogenesis and therapeutic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical safety profile of trastuzumab emtansine (T-DM1): mechanism of action of its cytotoxic component retained with improved tolerability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-independent gene expression mediated by SOX9 promotes aggressive pancreatic tumor biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure-response relationship of T-DM1: insight into dose optimization for patients with HER2-positive metastatic breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of anti-RON antibody Zt/g4-drug maytansinoid conjugation (Anti-RON ADC) as a novel therapeutics for targeted colorectal cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An FDA oncology analysis of antibody-drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic Cancer: A Review

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple negative breast cancer: Emerging therapeutic modalities and novel combination therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-Drug Conjugates for Cancer Treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE

1 reference

https://pubmed.ncbi.nlm.nih.gov/30871619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S40425-019-0525-0

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30871619%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s40425-019-0525-0

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30871619%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30871619%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

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