Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer (Q39048792)

5 July 2018

title

Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer (English)

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5 July 2018

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7

Everett E Vokes

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8

Ravi Salgia

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2

Rifat Hasina

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5 July 2018

Qudsia Arif

3

object named as

Qudsia Arif

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author name string

Ichiro Kawada

1

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5 July 2018

Jeffrey Mueller

4

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Erin Smithberger

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Aliya N Husain

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language of work or name

English

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publication date

4 December 2013

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5 July 2018

published in

Cancer Research

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5 July 2018

volume

74

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5 July 2018

issue

3

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5 July 2018

page(s)

884-895

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5 July 2018

MET inhibition in lung cancer

cites work

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Combined treatment with MET inhibitors and other therapies in lung cancer

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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

10 July 2018

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CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases

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Ethnic differences and functional analysis of MET mutations in lung cancer

10 July 2018

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Response prediction to a multitargeted kinase inhibitor in cancer cell lines and xenograft tumors using high-content tyrosine peptide arrays with a kinetic readout

10 July 2018

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RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant

10 July 2018

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Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients

10 July 2018

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10 July 2018

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Expression of the RON receptor tyrosine kinase and its association with gastric carcinoma versus normal gastric tissues

10 July 2018

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Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer

10 July 2018

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The tumor microenvironment and its role in promoting tumor growth

10 July 2018

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Expression and mutational analysis of MET in human solid cancers

10 July 2018

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Imatinib mesylate enhances therapeutic effects of gemcitabine in human malignant mesothelioma xenografts

10 July 2018

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Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion

10 July 2018

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

10 July 2018

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions

10 July 2018

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A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase

10 July 2018

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Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.

10 July 2018

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Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential

10 July 2018

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Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.

10 July 2018

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Cross-talk between the proto-oncogenes Met and Ron

10 July 2018

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10 July 2018

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10 July 2018

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Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841456

MET and phosphorylated MET as potential biomarkers in lung cancer

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841456

Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841456

High MET gene copy number leads to shorter survival in patients with non-small cell lung cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841456

Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients.

21 August 2018

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Inhibition of MET Receptor Tyrosine Kinase and Its Ligand Hepatocyte Growth Factor

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24305878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-12-3583

1 reference

5 July 2018

PMC publication ID

5841456

1 reference

5 July 2018

PubMed publication ID

24305878

1 reference

5 July 2018