An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion (Q58610784)

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1 May 2020

title

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30395540%20AND%20SRC:MED&resulttype=core&format=json

evasion of host immune response

1 May 2020

main subject

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10

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1 May 2020

author name string

John D Klement

1

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1 May 2020

Amy V Paschall

2

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1 May 2020

Priscilla S Redd

3

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1 May 2020

Mohammed L Ibrahim

4

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1 May 2020

Chunwan Lu

5

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1 May 2020

Dafeng Yang

6

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1 May 2020

Esteban Celis

7

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1 May 2020

Scott I Abrams

8

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1 May 2020

Keiko Ozato

9

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1 May 2020

language of work or name

English

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publication date

5 November 2018

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Journal of Clinical Investigation

1 May 2020

published in

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1 May 2020

volume

128

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1 May 2020

issue

12

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1 May 2020

page(s)

5549-5560

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Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody

1 May 2020

cites work

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12 December 2020

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

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Enhancement of antitumor immunity by CTLA-4 blockade

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Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

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CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen

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Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens

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Eradication of established tumors by CD8+ T cell adoptive immunotherapy

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The osteopontin-CD44 survival signal involves activation of the phosphatidylinositol 3-kinase/Akt signaling pathway

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12 December 2020

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling

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Antigen-driven effector CD8 T cell function regulated by T-bet

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Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies

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Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity

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12 December 2020

Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages.

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12 December 2020

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells

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12 December 2020

The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse

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PD-1 and its ligands in tolerance and immunity

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12 December 2020

Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas.

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12 December 2020

IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease

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12 December 2020

DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells

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12 December 2020

CD44 regulates survival and memory development in Th1 cells

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12 December 2020

Blockade of osteopontin reduces alloreactive CD8+ T cell–mediated graft-versus-host disease

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12 December 2020

IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools

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12 December 2020

IRF8 mutations and human dendritic-cell immunodeficiency

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12 December 2020

Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation

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12 December 2020

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

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12 December 2020

NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.

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12 December 2020

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12 December 2020

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors

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12 December 2020

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

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12 December 2020

Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells

1 reference

12 December 2020

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation

1 reference

12 December 2020

Molecular mechanisms of T cell co-stimulation and co-inhibition

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12 December 2020

Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 T-cell responses against established tumors

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12 December 2020

The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation

1 reference

12 December 2020

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation

1 reference

12 December 2020

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

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12 December 2020

TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes

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12 December 2020

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.

1 reference

12 December 2020

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection

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12 December 2020

Transcription factor IRF8 controls Th1-like regulatory T-cell function

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12 December 2020

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

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12 December 2020

CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection

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12 December 2020

Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.

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12 December 2020

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses

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12 December 2020

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

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12 December 2020

IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis.

1 reference

12 December 2020

Th17 cell differentiation proceeds independently of IRF8.

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12 December 2020

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells

1 reference

12 December 2020

Positive predictive value of breast lesions of uncertain malignant potential (B3): Can we identify high risk patients? The value of a multidisciplinary team and implications in the surgical treatment

1 reference

12 December 2020

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively

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12 December 2020

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

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12 December 2020

Biallelic mutations in IRF8 impair human NK cell maturation and function

1 reference

12 December 2020

The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells

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12 December 2020

Osteopontin attenuates acute gastrointestinal graft-versus-host disease by preventing apoptosis of intestinal epithelial cells

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12 December 2020

T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

1 reference

12 December 2020

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

1 reference

12 December 2020

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

1 reference

12 December 2020

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production

1 reference

12 December 2020

Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

1 reference

12 December 2020

Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.

1 reference

12 December 2020

The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors

1 reference

12 December 2020

IRF8-dependent molecular complexes control the Th9 transcriptional program.

1 reference

12 December 2020

PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.

1 reference

12 December 2020

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.

1 reference

12 December 2020

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.

1 reference

12 December 2020

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation

1 reference

12 December 2020

An early history of T cell-mediated cytotoxicity.

1 reference

12 December 2020

Defining and Understanding Adaptive Resistance in Cancer Immunotherapy

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12 December 2020

Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response

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12 December 2020

Identifiers

DOI

10.1172/JCI123360

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30395540%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30395540%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

30395540

1 reference