Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. (Q41825142)

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scientific article published on 29 May 2011

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English	Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.	scientific article published on 29 May 2011

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2 February 2020

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection (English)

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2 February 2020

Kenneth J Oestreich

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2 February 2020

Michael A Paley

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Alison Crawford

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Andrew Intlekofer

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2 February 2020

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E John Wherry

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2 February 2020

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Charlly Kao

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Jill M Angelosanto

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2 February 2020

Mohammed-Alkhatim A Ali

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2 February 2020

Jeremy M Boss

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Steven L Reiner

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2 February 2020

Amy S Weinmann

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2 February 2020

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29 May 2011

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2 February 2020

Nature Immunology

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2 February 2020

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2 February 2020

663-671

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2 February 2020

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels

1 reference

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6 June 2018

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

1 reference

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6 June 2018

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Redefining chronic viral infection

1 reference

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6 June 2018

Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

NFATc1 regulates PD-1 expression upon T cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Molecular signature of CD8+ T cell exhaustion during chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus

1 reference

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6 June 2018

Effector and memory CTL differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Restoring function in exhausted CD8 T cells during chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306165

6 June 2018

NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression

1 reference

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

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HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

1 reference

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Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.

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Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection

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IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

1 reference

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

1 reference

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 reference

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12 December 2020

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Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21623380

12 December 2020

based on heuristic

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10.1038/NI.2046

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2 February 2020

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2 February 2020

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