The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability (Q58552894)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28149270%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability (English)

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9 April 2020

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4

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9 April 2020

author name string

Ji-Seon Park

1

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9 April 2020

In Jung Ji

2

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9 April 2020

Dong-Hou Kim

3

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9 April 2020

Seung-Yong Yoon

5

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9 April 2020

language of work or name

English

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publication date

1 January 2016

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Frontiers in Neuroscience

9 April 2020

published in

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9 April 2020

volume

10

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9 April 2020

page(s)

618

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

9 April 2020

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The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

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Heterozygous TREM2 mutations in frontotemporal dementia

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TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

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Impaired differentiation of osteoclasts in TREM-2-deficient individuals

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Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

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Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

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Pattern recognition by TREM-2: binding of anionic ligands

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Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

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Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

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Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus

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Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

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Isomer-specific chromatographic profiling yields highly sensitive and specific potential N-glycan biomarkers for epithelial ovarian cancer.

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TREM2 in Alzheimer's disease

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Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

21 January 2018

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Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

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Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

21 January 2018

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

21 January 2018

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Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins

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The development of retrosynthetic glycan libraries to profile and classify the human serum N-linked glycome

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Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease

21 January 2018

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Frontobasal gray matter loss is associated with the TREM2 p.R47H variant

21 January 2018

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Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

21 January 2018

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TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

21 January 2018

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Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

21 January 2018

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TREM2 sustains microglial expansion during aging and response to demyelination

21 January 2018

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

21 January 2018

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An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene

21 January 2018

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Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

21 January 2018

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Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin

21 January 2018

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Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.

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PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241589

30 November 2018

Identifiers

DOI

10.3389/FNINS.2016.00618

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28149270%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

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9 April 2020

PubMed publication ID

28149270

1 reference