Individualising Therapy to Minimize Bacterial Multidrug Resistance. (Q53070940)

11 May 2018

http://europepmc.org/abstract/MED/29569104

title

Individualising Therapy to Minimize Bacterial Multidrug Resistance. (English)

1 reference

11 May 2018

http://europepmc.org/abstract/MED/29569104

main subject

multiple drug resistance

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Fekade Bruck Sime

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

J Lipman

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

J A Roberts

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

1 April 2018

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11 May 2018

http://europepmc.org/abstract/MED/29569104

published in

Drugs

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

78

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

621-641

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Comparison of the activity of antibiotic combinations in vitro with clinical outcome and resistance emergence in serious infection by Pseudomonas aeruginosa in non-neutropenic patients

8 June 2020

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Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

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Single-dose daily gentamicin therapy in urinary tract infection

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Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis

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Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients

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Twenty-four-hour area under the concentration-time curve/MIC ratio as a generic predictor of fluoroquinolone antimicrobial effect by using three strains of Pseudomonas aeruginosa and an in vitro pharmacodynamic model

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Adaptive mutations produce resistance to ciprofloxacin.

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Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

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Low dosage and long treatment duration of beta-lactam: risk factors for carriage of penicillin-resistant Streptococcus pneumoniae.

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Pharmacokinetic profiles of high-dose intravenous ciprofloxacin in severe sepsis. The Baragwanath Ciprofloxacin Study Group

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Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria

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The effect of moxifloxacin on its target topoisomerases from Escherichia coli and Staphylococcus aureus.

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12 December 2020

Combinations of vancomycin and beta-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin

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12 December 2020

In vitro exchange of fluoroquinolone resistance determinants between Streptococcus pneumoniae and viridans streptococci and genomic organization of the parE-parC region in S. mitis

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Activity of piperacillin/tazobactam in combination with amikacin, ciprofloxacin, and trovafloxacin against Pseudomonas aeruginosa by time-kill.

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Effect of short-course, high-dose amoxicillin therapy on resistant pneumococcal carriage: a randomized trial

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Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infections

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Pharmacokinetics and pharmacodynamics of aztreonam and tobramycin in hospitalized patients

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12 December 2020

Pharmacodynamics of cefepime in patients with Gram-negative infections

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12 December 2020

Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa

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12 December 2020

Activities of moxifloxacin against, and emergence of resistance in, Streptococcus pneumoniae and Pseudomonas aeruginosa in an in vitro pharmacokinetic model

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12 December 2020

In vitro activity of gatifloxacin alone and in combination with cefepime, meropenem, piperacillin and gentamicin against multidrug-resistant organisms

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12 December 2020

In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus.

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12 December 2020

Streptococcus pneumoniaeBacteremia: Duration of Previous Antibiotic Use and Association with Penicillin Resistance

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12 December 2020

C-reactive protein levels correlate with mortality and organ failure in critically ill patients

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12 December 2020

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

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12 December 2020

Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic model

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12 December 2020

Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing

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12 December 2020

Treatment and outcome of Pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis

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12 December 2020

Steady-state plasma and intrapulmonary concentrations of cefepime administered in continuous infusion in critically ill patients with severe nosocomial pneumonia

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12 December 2020

Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial

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12 December 2020

Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme

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12 December 2020

In vivo pharmacodynamic activity of daptomycin

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12 December 2020

Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid

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12 December 2020

Identification and susceptibility testing of Enterobacteriaceae and Pseudomonas aeruginosa by direct inoculation from positive BACTEC blood culture bottles into Vitek 2.

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12 December 2020

Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus

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12 December 2020

Plasma and lung concentrations of ceftazidime administered in continuous infusion to critically ill patients with severe nosocomial pneumonia

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12 December 2020

“Collateral Damage” from Cephalosporin or Quinolone Antibiotic Therapy

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12 December 2020

Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis

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12 December 2020

Outpatient antibiotic use in Europe and association with resistance: a cross-national database study

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12 December 2020

Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapy

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12 December 2020

In vitro selection of resistance in Pseudomonas aeruginosa and Acinetobacter spp. by levofloxacin and ciprofloxacin alone and in combination with beta-lactams and amikacin

1 reference

12 December 2020

Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials

1 reference

12 December 2020

Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa

1 reference

12 December 2020

Mutant prevention concentration for ciprofloxacin and levofloxacin with Pseudomonas aeruginosa

1 reference

12 December 2020

Effects of prolonged vancomycin administration on methicillin-resistant Staphylococcus aureus (MRSA) in a patient with recurrent bacteraemia

1 reference

12 December 2020

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

1 reference

12 December 2020

Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis.

1 reference

12 December 2020

beta-Lactam MICs correlate poorly with mutant prevention concentrations for clinical isolates of Acinetobacter spp. and Pseudomonas aeruginosa

1 reference

12 December 2020

Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic aspects of antimicrobial agents for the treatment of uncomplicated urinary tract infections.

1 reference

12 December 2020

Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii

1 reference

12 December 2020

Pharmacokinetics and tolerability of daptomycin at doses up to 12 milligrams per kilogram of body weight once daily in healthy volunteers

1 reference

12 December 2020

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model

1 reference

12 December 2020

Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia

1 reference

12 December 2020

The relationship between quinolone exposures and resistance amplification is characterized by an inverted U: a new paradigm for optimizing pharmacodynamics to counterselect resistance

1 reference

12 December 2020

Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy

1 reference

12 December 2020

Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model

1 reference

12 December 2020

Mutant selection window hypothesis updated.

1 reference

12 December 2020

Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis.

1 reference

12 December 2020

Prior antibiotics and risk of antibiotic-resistant community-acquired urinary tract infection: a case-control study

1 reference

12 December 2020

1 reference

12 December 2020

Daptomycin: a review 4 years after first approval

1 reference

12 December 2020

Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model.

1 reference

12 December 2020

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

1 reference

12 December 2020

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

1 reference

12 December 2020

Decrease in bacterial load versus resistance selection of pneumococcal subpopulations by beta-lactam physiological concentrations over time: an in vitro pharmacodynamic simulation

1 reference

12 December 2020

Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia

1 reference

12 December 2020

Evaluation of daptomycin pharmacodynamics and resistance at various dosage regimens against Staphylococcus aureus isolates with reduced susceptibilities to daptomycin in an in vitro pharmacodynamic model with simulated endocardial vegetations

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12 December 2020

Ciprofloxacin pharmacokinetics in critically ill patients: a prospective cohort study

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12 December 2020

Pharmacodynamic modeling of aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: identifying dosing regimens to suppress resistance development

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12 December 2020

Bacterial ventilator-associated pneumonia: bronchoalveolar lavage results are not influenced by dilution

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12 December 2020

Feedback dose alteration significantly affects probability of pathogen eradication in nosocomial pneumonia

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12 December 2020

Prospectively validated dosing nomograms for maximizing the pharmacodynamics of vancomycin administered by continuous infusion in critically ill patients

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12 December 2020

Pharmacokinetic issues for antibiotics in the critically ill patient

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12 December 2020

Differing effects of combination chemotherapy with meropenem and tobramycin on cell kill and suppression of resistance of wild-type Pseudomonas aeruginosa PAO1 and its isogenic MexAB efflux pump-overexpressed mutant

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12 December 2020

Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria.

1 reference

12 December 2020

Ciprofloxacin dosage and emergence of resistance in human commensal bacteria

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12 December 2020

In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing.

1 reference

12 December 2020

Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia

1 reference

12 December 2020

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

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12 December 2020

Sepsis biomarkers: a review

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12 December 2020

Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis

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12 December 2020

In vitro prevention of the emergence of daptomycin resistance in Staphylococcus aureus and enterococci following combination with amoxicillin/clavulanic acid or ampicillin

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12 December 2020

Treatment with fluoroquinolones or with beta-lactam-beta-lactamase inhibitor combinations is a risk factor for isolation of extended-spectrum-beta-lactamase-producing Klebsiella species in hospitalized patients

1 reference

12 December 2020

Extracellular concentrations of fosfomycin in lung tissue of septic patients

1 reference

12 December 2020

Mutant prevention concentrations of four carbapenems against gram-negative rods

1 reference

12 December 2020

Pharmacokinetics of moxifloxacin in patients with severe sepsis or septic shock

1 reference

12 December 2020

MICs, MPCs and PK/PDs: a match (sometimes) made in hosts

1 reference

12 December 2020

Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis.

1 reference

12 December 2020

Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit.

1 reference

12 December 2020

Support for higher ciprofloxacin AUC 24/MIC targets in treating Enterobacteriaceae bloodstream infection

1 reference

12 December 2020

Steady-state pharmacokinetics and BAL concentration of colistin in critically Ill patients after IV colistin methanesulfonate administration

1 reference

12 December 2020

fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.

1 reference

12 December 2020

Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

1 reference

12 December 2020

Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: A systematic review and meta-analysis of randomized controlled trials

1 reference

12 December 2020

Amikacin monotherapy for sepsis caused by panresistant Pseudomonas aeruginosa

1 reference

12 December 2020

Cephalosporin and fluoroquinolone combinations are highly associated with CTX-M β-lactamase-producing Escherichia coli: a case–control study in a French teaching hospital

1 reference

12 December 2020

Optimization of Aminoglycoside Therapy

1 reference

12 December 2020

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study.

1 reference

12 December 2020

Preferential emergence of reduced vancomycin susceptibility in health care-associated methicillin-resistant Staphylococcus aureus isolates during continuous-infusion vancomycin therapy in an in vitro dynamic model

1 reference

12 December 2020

Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients

1 reference

12 December 2020

Effect of ciprofloxacin concentration on the frequency and nature of resistant mutants selected from Pseudomonas aeruginosa mutS and mutT hypermutators

1 reference

12 December 2020

Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections

1 reference

12 December 2020

Clinical pharmacokinetic/pharmacodynamic profile of linezolid in severely ill Intensive Care Unit patients

1 reference

12 December 2020

TDM-guided therapy with daptomycin and meropenem in a morbidly obese, critically ill patient.

1 reference

12 December 2020

Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms

1 reference

12 December 2020

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula

1 reference

12 December 2020

Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antibacterial agents

1 reference

12 December 2020

The revival of fosfomycin

1 reference

12 December 2020

Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa

1 reference

12 December 2020

In Vitro Pharmacodynamics of Vancomycin and Cefazolin Alone and in Combination against Methicillin-Resistant Staphylococcus aureus

1 reference

12 December 2020

Evaluation of once-daily vancomycin against methicillin-resistant Staphylococcus aureus in a hollow-fiber infection model

1 reference

12 December 2020

High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study.

1 reference

12 December 2020

β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review

1 reference

12 December 2020

Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.

1 reference

12 December 2020

The ciprofloxacin target AUC : MIC ratio is not reached in hospitalized patients with the recommended dosing regimens

1 reference

12 December 2020

Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations

1 reference

12 December 2020

Epidemiological and clinical features associated with colonisation/infection by Acinetobacter baumannii with phenotypic heterogeneous resistance to carbapenems

1 reference

12 December 2020

Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients

1 reference

12 December 2020

Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

1 reference

12 December 2020

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections

1 reference

12 December 2020

Comparative in vitro and in vivo efficacies of human simulated doses of ceftazidime and ceftazidime-avibactam against Pseudomonas aeruginosa

1 reference

12 December 2020

Concentration-resistance relationships with Pseudomonas aeruginosa exposed to doripenem and ciprofloxacin in an in vitro model

1 reference

12 December 2020

Inoculum effects of ceftobiprole, daptomycin, linezolid, and vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at inocula of 10(5) and 10(7) CFU injected into opposite thighs of neutropenic mice

1 reference

12 December 2020

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia

1 reference

12 December 2020

Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis

1 reference

12 December 2020

Gram-negative resistance: can we combat the coming of a new "Red Plague"?

1 reference

12 December 2020

Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections

1 reference

12 December 2020

Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

1 reference

12 December 2020

Relationship between ceftolozane-tazobactam exposure and drug resistance amplification in a hollow-fiber infection model

1 reference

12 December 2020

Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections

1 reference

12 December 2020

Therapeutic drug monitoring of amikacin in septic patients.

1 reference

12 December 2020

Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial

1 reference

12 December 2020

Comparative study of the mutant prevention concentrations of vancomycin alone and in combination with levofloxacin, rifampicin and fosfomycin against methicillin-resistant Staphylococcus epidermidis

1 reference

12 December 2020

Impact of Bolus dosing versus continuous infusion of Piperacillin and Tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa.

1 reference

12 December 2020

Considerations for higher doses of daptomycin in critically ill patients with methicillin-resistant Staphylococcus aureus bacteremia.

1 reference

12 December 2020

Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock--a systematic review and meta-analysis

1 reference

12 December 2020

A randomized double-blind placebo-controlled dose-escalation phase 1 study of aerosolized amikacin and fosfomycin delivered via the PARI investigational eFlow® inline nebulizer system in mechanically ventilated patients

1 reference

12 December 2020

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

1 reference

12 December 2020

Activities of ceftazidime and avibactam against β-lactamase-producing Enterobacteriaceae in a hollow-fiber pharmacodynamic model

1 reference

12 December 2020

Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model

1 reference

12 December 2020

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

1 reference

12 December 2020

Fluoroquinolone- and ceftriaxone-based therapy of community-acquired pneumonia in hospitalized patients: the risk of subsequent isolation of multidrug-resistant organisms

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12 December 2020

How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?

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12 December 2020

Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study

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12 December 2020

Emergence of quinolone resistance in the microbiota of hospitalized patients treated or not with a fluoroquinolone

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12 December 2020

Vancomycin and piperacillin-tazobactam against methicillin-resistant Staphylococcus aureus and vancomycin-intermediate Staphylococcus aureus in an in vitro pharmacokinetic/pharmacodynamic model

1 reference

12 December 2020

Relationship between ceftolozane-tazobactam exposure and selection for Pseudomonas aeruginosa resistance in a hollow-fiber infection model

1 reference

12 December 2020

Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment

1 reference

12 December 2020

Evaluation of meropenem regimens suppressing emergence of resistance in Acinetobacter baumannii with human simulated exposure in an in vitro intravenous-infusion hollow-fiber infection model

1 reference

12 December 2020

Modelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study

1 reference

12 December 2020

Population pharmacokinetics of single-dose amikacin in critically ill patients with suspected ventilator-associated pneumonia.

1 reference

12 December 2020

A randomized trial of loading vancomycin in the emergency department

1 reference

12 December 2020

Mutant prevention concentrations of imipenem and meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii

1 reference

12 December 2020

Impact of imipenem and amikacin pharmacokinetic/pharmacodynamic parameters on microbiological outcome of Gram-negative bacilli ventilator-associated pneumonia.

1 reference

12 December 2020

Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development

1 reference

12 December 2020

Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii

1 reference

12 December 2020

Cefepime free minimum concentration to minimum inhibitory concentration (fCmin/MIC) ratio predicts clinical failure in patients with Gram-negative bacterial pneumonia

1 reference

12 December 2020

Risk factors for acquisition of multidrug-resistant bacteria in patients with anastomotic leakage after colorectal cancer surgery

1 reference

12 December 2020

Killing of Streptococcus pneumoniae by azithromycin, clarithromycin, erythromycin, telithromycin and gemifloxacin using drug minimum inhibitory concentrations and mutant prevention concentrations

1 reference

12 December 2020

Even high-dose extended infusions may not yield desired concentrations of β-lactams: the value of therapeutic drug monitoring.

1 reference

12 December 2020

Standard dosing of amikacin and gentamicin in critically ill patients results in variable and subtherapeutic concentrations

1 reference

12 December 2020

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics

1 reference

12 December 2020

Trial of short-course antimicrobial therapy for intraabdominal infection.

1 reference

12 December 2020

Exploration of the Pharmacokinetic-Pharmacodynamic Relationships for Fosfomycin Efficacy Using an In Vitro Infection Model

1 reference

12 December 2020

Pharmacodynamics of fosfomycin: insights into clinical use for antimicrobial resistance

1 reference

12 December 2020

Vancomycin-associated nephrotoxicity: A meta-analysis of administration by continuous versus intermittent infusion

1 reference

12 December 2020

Antimicrobial Activity of Fosfomycin-Tobramycin Combination against Pseudomonas aeruginosa Isolates Assessed by Time-Kill Assays and Mutant Prevention Concentrations

1 reference

12 December 2020

Population Pharmacokinetics of Fosfomycin in Critically Ill Patients.

1 reference

12 December 2020

Polymyxin B in Combination with Antimicrobials Lacking In Vitro Activity versus Polymyxin B in Monotherapy in Critically Ill Patients with Acinetobacter baumannii or Pseudomonas aeruginosa Infections

1 reference

12 December 2020

Pharmacokinetic/pharmacodynamic considerations for the optimization of antimicrobial delivery in the critically ill.

1 reference

12 December 2020

Combination of Vancomycin and β-Lactam Therapy for Methicillin-ResistantStaphylococcus aureusBacteremia: A Pilot Multicenter Randomized Controlled Trial

1 reference

12 December 2020

Are ciprofloxacin dosage regimens adequate for antimicrobial efficacy and prevention of resistance? Pseudomonas aeruginosa bloodstream infection in elderly patients as a simulation case study

1 reference

12 December 2020

Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis.

1 reference

12 December 2020

Defining Clinical Exposures of Cefepime for Gram-Negative Bloodstream Infections That Are Associated with Improved Survival.

1 reference

12 December 2020

Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure.

1 reference

12 December 2020

Predicting and preventing antimicrobial resistance utilizing pharmacodynamics: Part I gram positive bacteria

1 reference

12 December 2020

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.

1 reference

12 December 2020

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

1 reference

12 December 2020

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa

1 reference

12 December 2020

Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial.

1 reference

12 December 2020

Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials

1 reference

12 December 2020

Therapeutic drug monitoring of anti-infective agents in critically ill patients

1 reference

12 December 2020

Is high-dose β-lactam therapy associated with excessive drug toxicity in critically ill patients?

1 reference

12 December 2020

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance

1 reference

12 December 2020

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

1 reference

12 December 2020

Clinically relevant concentrations of fosfomycin combined with polymyxin B, tobramycin or ciprofloxacin enhance bacterial killing of Pseudomonas aeruginosa, but do not suppress the emergence of fosfomycin resistance.

1 reference

12 December 2020

Procalcitonin-guided therapy for the initiation of antibiotics in the ED: a systematic review

1 reference

12 December 2020

Progress in the Fight Against Multidrug-Resistant Bacteria? A Review of U.S. Food and Drug Administration-Approved Antibiotics, 2010-2015.

1 reference

12 December 2020

Pharmacodynamics of carbapenems for the treatment of Pseudomonas aeruginosa ventilator-associated pneumonia: associations with clinical outcome and recurrence

1 reference

12 December 2020

Bacteremia due to carbapenem-resistant Enterobacteriaceae in neutropenic patients with hematologic malignancies

1 reference

12 December 2020

Daptomycin Pharmacokinetics and Pharmacodynamics in Septic and Critically Ill Patients

1 reference

12 December 2020

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

1 reference

12 December 2020

Absence of obvious link between supra-therapeutic serum levels of β lactams and clinical toxicity in ICU patients with acute renal failure treated with intermittent hemodialysis

1 reference

12 December 2020

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

1 reference

12 December 2020

Mutant prevention concentration of colistin alone and in combination with rifampicin for multidrug-resistant Acinetobacter baumannii.

1 reference

12 December 2020

Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

1 reference

12 December 2020

Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii

1 reference

12 December 2020

Pharmacodynamics of Aerosolized Fosfomycin and Amikacin against Resistant Clinical Isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a Hollow-Fiber Infection Model: Experimental Basis for Combination Therapy

1 reference

12 December 2020

Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock.

1 reference

12 December 2020

Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling

1 reference

12 December 2020

Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients

1 reference

12 December 2020

Procalcitonin-guided diagnosis and antibiotic stewardship revisited

1 reference

12 December 2020

Determining β-lactam exposure threshold to suppress resistance development in Gram-negative bacteria

1 reference

12 December 2020

Nebulization of Antiinfective Agents in Invasively Mechanically Ventilated Adults: A Systematic Review and Meta-analysis

1 reference

12 December 2020

Pharmacodynamics of tigecycline alone and in combination with colistin against clinical isolates of multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

1 reference

12 December 2020

In Vivo Pharmacokinetics and Pharmacodynamics of ZTI-01 (Fosfomycin for Injection) in the Neutropenic Murine Thigh Infection Model against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

1 reference

12 December 2020

A 10-Year Experience of Therapeutic Drug Monitoring (TDM) of Linezolid in a Hospital-wide Population of Patients Receiving Conventional Dosing: Is there Enough Evidence for Suggesting TDM in the Majority of Patients?

1 reference

12 December 2020

Biomarker-guided antibiotic therapy-strengths and limitations

1 reference

12 December 2020

Emergence of antimicrobial resistance to Pseudomonas aeruginosa in the intensive care unit: association with the duration of antibiotic exposure and mode of administration.

1 reference

12 December 2020

Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact

1 reference

12 December 2020

Is a randomized trial of a short course of aminoglycoside added to β-lactam antibiotics for empirical treatment in critically ill patients with sepsis justified?

1 reference

12 December 2020

Evaluation of Activity and Emergence of Resistance of Polymyxin B and ZTI-01 (Fosfomycin for Injection) against KPC-Producing Klebsiella pneumoniae

1 reference

12 December 2020

MIC-based dose adjustment: facts and fables

1 reference

12 December 2020

Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model.

1 reference

12 December 2020

Is a randomized trial of a short course of aminoglycoside added to beta lactam antibiotics for empirical treatment in critically ill patients with sepsis justified?

1 reference

12 December 2020

10.1007/S40265-018-0891-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29569104%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference