Mutant selection window hypothesis updated. (Q36728061)

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25 December 2019

review article

1 reference

title

Mutant selection window hypothesis updated (English)

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25 December 2019

2

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25 December 2019

author name string

Karl Drlica

series ordinal

1

1 reference

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25 December 2019

language of work or name

English

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publication date

24 January 2007

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Clinical Infectious Diseases

25 December 2019

published in

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25 December 2019

volume

44

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25 December 2019

issue

5

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25 December 2019

page(s)

681-688

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Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies

25 December 2019

cites work

1 reference

Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window

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Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance

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Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia

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Selection of antibiotic-resistant bacterial mutants: allelic diversity among fluoroquinolone-resistant mutations.

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Mutant prevention concentration as a measure of fluoroquinolone potency against mycobacteria

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Mutant prevention concentration for ciprofloxacin and levofloxacin with Pseudomonas aeruginosa

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Effect of chloramphenicol, erythromycin, moxifloxacin, penicillin and tetracycline concentration on the recovery of resistant mutants of Mycobacterium smegmatis and Staphylococcus aureus

21 January 2018

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Selection of Streptococcus pneumoniae mutants having reduced susceptibility to moxifloxacin and levofloxacin.

21 January 2018

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Resistance to antibiotics mediated by target alterations

21 January 2018

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Resistance to beta-lactam antibiotics

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Mutation prevention concentration of ceftriaxone, meropenem, imipenem, and ertapenem against three strains of Streptococcus pneumoniae

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Mutant prevention concentration as a measure of antibiotic potency: studies with clinical isolates of Mycobacterium tuberculosis

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Effect of Rifampin on Nasal Carriage of Staphylococcus aureus

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Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

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Low correlation between MIC and mutant prevention concentration

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Pharmacodynamic modeling of ciprofloxacin resistance in Staphylococcus aureus

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Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

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Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae.

21 January 2018

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The role of PK/PD parameters to avoid selection and increase of resistance: mutant prevention concentration

21 January 2018

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In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus.

21 January 2018

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Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing

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Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus

21 January 2018

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Evolution of ciprofloxacin-resistant Staphylococcus aureus in in vitro pharmacokinetic environments

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Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update

21 January 2018

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Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

21 January 2018

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Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection models

21 January 2018

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Effect of low-level resistance on subsequent enrichment of fluoroquinolone-resistant Streptococcus pneumoniae in rabbits.

21 January 2018

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In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants.

21 January 2018

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The mutant selection window in rabbits infected with Staphylococcus aureus

21 January 2018

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Selection of rifampicin-resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquisition of resistance

21 January 2018

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In vitro activity of ciprofloxacin, a new carboxyquinoline antimicrobial agent

21 January 2018

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Quinolone-resistant Haemophilus influenzae: determination of mutant selection window for ciprofloxacin, garenoxacin, levofloxacin, and moxifloxacin

21 January 2018

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Mobile gene cassettes: a fundamental resource for bacterial evolution

21 January 2018

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The role of mutators in the emergence of antibiotic-resistant bacteria

21 January 2018

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Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infections

21 January 2018

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Staphylococcus aureus mutants selected by BMS-284756.

21 January 2018

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Activity of the novel des-fluoro(6) quinolone BMS-284756 against methicillin-susceptible and -resistant staphylococci

21 January 2018

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Activity and spectrum of BMS 284756, a new des-F (6) quinolone, tested against strains of ciprofloxacin-resistant Gram-positive cocci

21 January 2018

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The in vitro activity of BMS-284756, a new des-fluorinated quinolone

21 January 2018

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Trends in bacterial resistance to fluoroquinolones

21 January 2018

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Fluoroquinolones as pneumococcal therapy: closing the barn door before the horse escapes

21 January 2018

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Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus.

21 January 2018

1 reference

Multiple-dose safety and pharmacokinetics of oral garenoxacin in healthy subjects

21 January 2018

1 reference

The mutant selection window and antimicrobial resistance

21 January 2018

1 reference

ABT492 and levofloxacin: comparison of their pharmacodynamics and their abilities to prevent the selection of resistant Staphylococcus aureus in an in vitro dynamic model

21 January 2018

1 reference

Concentration-dependent changes in the susceptibility and killing of Staphylococcus aureus in an in vitro dynamic model that simulates normal and impaired gatifloxacin elimination.

21 January 2018

1 reference

Multiple-dose pharmacokinetics and safety of ciprofloxacin in normal volunteers

21 January 2018

1 reference

Low-level antibacterial resistance: a gateway to clinical resistance

21 January 2018

1 reference