Overview of Basic Immunology for Clinical Investigators. (Q52699143)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28321810%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Overview of Basic Immunology for Clinical Investigators (English)

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13 March 2020

2

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13 March 2020

author name string

Bettzy Stephen

series ordinal

1

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13 March 2020

language of work or name

English

0 references

publication date

1 January 2017

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Advances in Experimental Medicine and Biology

13 March 2020

published in

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13 March 2020

volume

995

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13 March 2020

page(s)

1-31

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The new deal: a potential role for secreted vesicles in innate immunity and tumor progression

13 March 2020

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Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

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The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

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The neutrophil as a cellular source of chemokines

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Role of tumor-associated macrophages in tumor progression and invasion

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Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy

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Vascular endothelial growth factor-165 overexpression stimulates angiogenesis and induces cyst formation and macrophage infiltration in human ovarian cancer xenografts

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Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy

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High macrophage infiltration along the tumor front correlates with improved survival in colon cancer.

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Targeting eosinophils in allergy, inflammation and beyond

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Eosinophils: multifaceted biological properties and roles in health and disease

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Eosinophil crystalloid granules: structure, function, and beyond

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CD40 expression by human peripheral blood eosinophils

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Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon gamma): inhibition by immunoglobulin a complexes

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Lymph node trafficking and antigen presentation by endobronchial eosinophils

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Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

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Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

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IgE, mast cells, basophils, and eosinophils

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Mast cells and mastocytosis

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Characterization of mast cell subpopulations in lip cancer

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Mast cells as target in cancer therapy

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The role of mast cells in tumour angiogenesis

21 January 2018

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Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases

21 January 2018

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Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer

21 January 2018

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Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer

21 January 2018

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Mast cell-mediated apoptosis of endothelial cells in vitro: a paracrine mechanism involving TNF-alpha-mediated down-regulation of bcl-2 expression

21 January 2018

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Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions

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Molecular control of steady-state dendritic cell maturation and immune homeostasis

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Origin and development of dendritic cells

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Steady-state and inflammatory dendritic-cell development

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Cell biology of antigen processing in vitro and in vivo

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Decisions About Dendritic Cells: Past, Present, and Future

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In search of the 'missing self': MHC molecules and NK cell recognition

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Natural killer cell signaling pathways

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IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

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The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic

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Developing a new paradigm for thymus organogenesis.

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The thymus selects the useful, neglects the useless and destroys the harmful

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Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

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Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

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T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

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Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

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T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

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CTLA-4 is a second receptor for the B cell activation antigen B7

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

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PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

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The blockade of immune checkpoints in cancer immunotherapy

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Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

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GITR: a modulator of immune response and inflammation.

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The role of TNF superfamily members in T-cell function and diseases

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Microenvironmental niches in the bone marrow required for B-cell development

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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Receptor editing in self-reactive bone marrow B cells

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Transitional B cells are the target of negative selection in the B cell compartment

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B-cell biology and development

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Germinal center selection and the development of memory B and plasma cells

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Structure and function of immunoglobulins

21 January 2018

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Monoclonal versus polyclonal antibodies: distinguishing characteristics, applications, and information resources

21 January 2018

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Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

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Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains

21 January 2018

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Reshaping human antibodies for therapy

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The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

21 January 2018

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Antibody therapy of cancer

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The immune contexture in human tumours: impact on clinical outcome

21 January 2018

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The three Es of cancer immunoediting

21 January 2018

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Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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From mice to humans: developments in cancer immunoediting

21 January 2018

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Cancer immunotherapy comes of age

21 January 2018

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Coordinated regulation of myeloid cells by tumours

21 January 2018

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The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

21 January 2018

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Rationally engineered proteins or antibodies with absent or reduced immunogenicity

21 January 2018

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Monoclonal antibodies: versatile platforms for cancer immunotherapy

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

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Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

21 January 2018

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Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

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Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

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Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

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Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

21 January 2018

1 reference

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Rationale for anti-OX40 cancer immunotherapy

21 January 2018

1 reference

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Cancer immunotherapy comes of age

21 January 2018

1 reference

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Targeting the indoleamine 2,3-dioxygenase pathway in cancer

21 January 2018

1 reference

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Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors

21 January 2018

1 reference

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Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

21 January 2018

1 reference

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IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.

21 January 2018

1 reference

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Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

21 January 2018

1 reference

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Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

21 January 2018

1 reference

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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

21 January 2018

1 reference

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The future of immune checkpoint therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Effector CD4 and CD8 T cells and their role in the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

21 January 2018

1 reference

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Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

21 January 2018

1 reference

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Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

21 January 2018

1 reference

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Genetic basis for clinical response to CTLA-4 blockade in melanoma

21 January 2018

1 reference

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Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

21 January 2018

1 reference

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PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials

21 January 2018

1 reference

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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

21 January 2018

1 reference

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Immuno-oncology: understanding the function and dysfunction of the immune system in cancer

31 March 2020

1 reference

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Close encounters of neutrophils and DCs

31 March 2020

1 reference

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Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF- B Activation in Tumor-Associated Macrophages

31 March 2020

1 reference

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Prognostic value of tumor-associated macrophage count in human bladder cancer

31 March 2020

1 reference

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Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas

31 March 2020

1 reference

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Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas

31 March 2020

1 reference

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[Eosinophils and antitumour response]

31 March 2020

1 reference

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Granulocytes: Eosinophils enable the antitumour T cell response

31 March 2020

1 reference

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Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease

31 March 2020

1 reference

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Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer

31 March 2020

1 reference

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Mast cells in diffuse large B-cell lymphoma; their role in fibrosis

31 March 2020

1 reference

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Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer

31 March 2020

1 reference

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The Interactions of Multiple Cytokines Control NK Cell Maturation

31 March 2020

1 reference

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Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment

31 March 2020

1 reference

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-53156-4_1

Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients

31 March 2020

1 reference

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Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival

31 March 2020

1 reference

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10.1007/978-3-319-53156-4_1

31 March 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28321810%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference