Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review. (Q48136845)

PubMed publication ID

29230671

9 February 2018

http://europepmc.org/abstract/MED/29230671

review article

1 reference

title

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6428576&resulttype=core&format=json

13 May 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Fadi Taza

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

6

Michael J Spinella

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Maitri Kalra

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Noah Hahn

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Kenneth P Nephew

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Costantine Albany

7

1 reference

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12 June 2020

publication date

11 December 2017

1 reference

PubMed publication ID

29230671

9 February 2018

http://europepmc.org/abstract/MED/29230671

published in

Targeted oncology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

49-60

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

Hallmarks of Cancer: The Next Generation

12 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetics in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Nucleosome remodeling and epigenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Histone acetylation in chromatin structure and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Non–coding RNA genes and the modern RNA world

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The epigenomics of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

DNA methylome profiling beyond promoters - taking an epigenetic snapshot of the breast tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenome-based personalized medicine in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The evidence for functional non-CpG methylation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Genomic distribution and inter-sample variation of non-CpG methylation across human cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetic Targeting of Platinum Resistant Testicular Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetic synergy between decitabine and platinum derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetic resensitization to platinum in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Prospects for combining targeted and conventional cancer therapy with immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Endogenous retroviruses: acquisition, amplification and taming of genome invaders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Immune responses to endogenous retroelements: taking the bad with the good

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The epigenome of testicular germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Characteristic promoter hypermethylation signatures in male germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Alterations of DNA methylome in human bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Promoter analysis of epigenetically controlled genes in bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Role of DNA methylation in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2'-deoxycytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Methylation of the ASC gene promoter is associated with aggressive prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Phase I/II study of azacitidine, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Transcriptional Repressive H3K9 and H3K27 Methylations Contribute to DNMT1-Mediated DNA Methylation Recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetic mechanisms in penile carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11523-017-0546-X

Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells

21 January 2018

1 reference

12 December 2020

Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms

1 reference

12 December 2020

Activation of the MN/CA9 gene is associated with hypomethylation in human renal cell carcinoma cell lines

1 reference

12 December 2020

Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features

1 reference

12 December 2020

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine

1 reference

12 December 2020

Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

1 reference

12 December 2020

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

1 reference

12 December 2020

Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.

1 reference

12 December 2020

DNA methylation and cancer

1 reference

12 December 2020

Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines

1 reference

12 December 2020

Azacitidine favorably modulates PSA kinetics correlating with plasma DNA LINE-1 hypomethylation in men with chemonaïve castration-resistant prostate cancer

1 reference

12 December 2020

DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells

1 reference

12 December 2020

Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance

1 reference

12 December 2020

An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer

1 reference

12 December 2020

Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: a novel epigenetic approach to human urothelial carcinoma drug development

1 reference

12 December 2020

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

12 December 2020

Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression

1 reference

12 December 2020

5-azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

1 reference

12 December 2020

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

1 reference

12 December 2020

10.1007/S11523-017-0546-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

release_pborudfwmraf5dhyrmua2zq3h4

12 June 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/pborudfwmraf5dhyrmua2zq3h4

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29230671%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

29230671

1 reference