The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism (Q46902000)

26 December 2017

title

The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism (English)

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26 December 2017

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26 December 2017

Marie-Isabel Aguilar

9

object named as

Marie-Isabel Aguilar

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26 December 2017

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Steven Petratos

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26 December 2017

author name string

Qiao-Xin Li

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26 December 2017

Xu Hou

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26 December 2017

Megan L Kerr

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26 December 2017

Sharon E Unabia

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26 December 2017

Irene Hatzinisiriou

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26 December 2017

Danuta Maksel

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26 December 2017

David H Small

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26 December 2017

language of work or name

English

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publication date

13 November 2007

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26 December 2017

published in

Brain

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26 December 2017

volume

131

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26 December 2017

issue

Pt 1

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26 December 2017

page(s)

90-108

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26 December 2017

Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse

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Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones

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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

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Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

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21 January 2018

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Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells

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Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

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Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522

21 January 2018

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Lipid rafts mediate chemotropic guidance of nerve growth cones

21 January 2018

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Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites

21 January 2018

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A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution

21 January 2018

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Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

21 January 2018

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

21 January 2018

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Identifying novel substrates for mouse Cdk5 kinase using the yeast Saccharomyces cerevisiae

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 January 2018

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APP processing and synaptic function

21 January 2018

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The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination

21 January 2018

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Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells

21 January 2018

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Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption

21 January 2018

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Targeting the Nogo receptor to treat central nervous system injuries

21 January 2018

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Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.

21 January 2018

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Beta-amyloid fibril formation is promoted by step edges of highly oriented pyrolytic graphite

21 January 2018

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The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases

21 January 2018

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Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.

21 January 2018

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The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes

21 January 2018

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Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat

21 January 2018

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Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

21 January 2018

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The Nogo-66 receptor: focusing myelin inhibition of axon regeneration

21 January 2018

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Genes necessary for directed axonal elongation or fasciculation in C. elegans

21 January 2018

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition

21 January 2018

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Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice

21 January 2018

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Degenerative and regenerative mechanisms governing spinal cord injury.

21 January 2018

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

21 January 2018

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Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

21 January 2018

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Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues

21 January 2018

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The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Lipid rafts in neuronal signaling and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Rho proteins, mental retardation and the neurobiological basis of intelligence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Delayed Nogo receptor therapy improves recovery from spinal cord contusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Regulators of Rho GTPases in neuronal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Signaling networks in neuronal polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Signalling and crosstalk of Rho GTPases in mediating axon guidance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Axonal morphogenesis controlled by antagonistic roles of two CRMP subtypes in microtubule organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

CRMP-2 induces axons in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWM260

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWM260

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26 December 2017

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26 December 2017