Using a low denaturant model to explore the conformational features of translocation-active SecA. (Q41808503)

12 October 2017

Using a low denaturant model to explore the conformational features of translocation-active SecA. (English)

1 reference

12 October 2017

Jenny L Maki

1

1 reference

PMC publication ID

3290997

12 October 2017

Beena Krishnan

series ordinal

2

1 reference

PMC publication ID

3290997

12 October 2017

Lila M Gierasch

series ordinal

3

1 reference

PMC publication ID

3290997

12 October 2017

language of work or name

English

0 references

publication date

8 February 2012

1 reference

12 October 2017

1 reference

12 October 2017

51

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12 October 2017

7

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12 October 2017

1369-1379

1 reference

Characterization of the Escherichia coli SecA Signal Peptide-Binding Site

12 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

SecA, a remarkable nanomachine

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

SecA: a tale of two protomers

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Mapping of the signal peptide-binding domain of Escherichia coli SecA using Förster resonance energy transfer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

The lateral gate of SecYEG opens during protein translocation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Sending signals dynamically

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Conformational transition of Sec machinery inferred from bacterial SecYE structures

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Structure of a complex of the ATPase SecA and the protein-translocation channel

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Reexamination of the role of the amino terminus of SecA in promoting its dimerization and functional state

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

SecA, the motor of the secretion machine, binds diverse partners on one interactive surface

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Protein translocation across the bacterial cytoplasmic membrane.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Bacterial protein secretion through the translocase nanomachine

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Cross-linked SecA dimers are not functional in protein translocation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Selective photoaffinity labeling identifies the signal peptide binding domain on SecA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Identification of the preprotein binding domain of SecA.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Dimeric SecA is essential for protein translocation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Structure and function of SecA, the preprotein translocase nanomotor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Helicase Motif III in SecA is essential for coupling preprotein binding to translocation ATPase.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

A large conformational change of the translocation ATPase SecA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

VADAR: a web server for quantitative evaluation of protein structure quality

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Complex behavior in solution of homodimeric SecA.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Protein folding intermediates and pathways studied by hydrogen exchange

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Stability and Solvent Accessibility of SecA Protein of Escherichia coli

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Topology of the Integral Membrane Form of Escherichia coli SecA Protein Reveals Multiple Periplasmically Exposed Regions and Modulation by ATP Binding

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Membrane-bound conformation of a signal peptide: a transferred nuclear Overhauser effect analysis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Interaction of an apolipoprotein (apoLP-alanine) with phosphatidylcholine.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

ATP is essential for protein translocation into Escherichia coli membrane vesicles

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

The proton motive force lowers the level of ATP required for the in vitro translocation of a secretory protein in Escherichia coli.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Involvement of denaturation-like changes in Pseudomonas exotoxin a hydrophobicity and membrane penetration determined by characterization of pH and thermal transitions. Roles of two distinct conformationally altered states

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

An improved assay for nanomole amounts of inorganic phosphate

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

A role for the two-helix finger of the SecA ATPase in protein translocation.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Additional in vitro and in vivo evidence for SecA functioning as dimers in the membrane: dissociation into monomers is not essential for protein translocation in Escherichia coli

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Covalently dimerized SecA is functional in protein translocation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Conformational state of the SecYEG-bound SecA probed by single tryptophan fluorescence spectroscopy

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

The bacterial ATPase SecA functions as a monomer in protein translocation.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Functionally significant mobile regions of Escherichia coli SecA ATPase identified by NMR.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Lipid and signal peptide-induced conformational changes within the C-domain of Escherichia coli SecA protein

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Identification of a region of interaction between Escherichia coli SecA and SecY proteins.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

The C terminus of SecA is involved in both lipid binding and SecB binding.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Disorder-order folding transitions underlie catalysis in the helicase motor of SecA

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290997

Nucleotide binding activity of SecA homodimer is conformationally regulated by temperature and altered by prlD and azi mutations

2 December 2018

1 reference

12 December 2020

In vitro translocation of protein across Escherichia coli membrane vesicles requires both the proton motive force and ATP

1 reference

12 December 2020

Separable ATPase and Membrane Insertion Domains of the SecA Subunit of Preprotein Translocase

1 reference

12 December 2020

Thermodynamics of nucleotide binding to NBS-I of the Bacillus subtilis preprotein translocase subunit SecA

1 reference

12 December 2020

Quaternary Structure of SecA in Solution and Bound to SecYEG Probed at the Single Molecule Level

1 reference

12 December 2020

A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA

1 reference

12 December 2020

SecA folds via a dimeric intermediate

1 reference

12 December 2020

A molecular switch in SecA protein couples ATP hydrolysis to protein translocation

1 reference

12 December 2020

https://api.fatcat.wiki/v0/release/mc372ucve5gyvitkpemmokbeoy

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30 July 2022

release_mc372ucve5gyvitkpemmokbeoy

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https://api.fatcat.wiki/v0/release/mc372ucve5gyvitkpemmokbeoy

30 July 2022

https://api.fatcat.wiki/v0/release/mc372ucve5gyvitkpemmokbeoy

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30 July 2022

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30 July 2022