α2-Macroglobulins: Structure and Function (Q40304036)

19 September 2017

title

α2-Macroglobulins: Structure and Function (English)

1 reference

19 September 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Theodoros Goulas

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Irene Garcia-Ferrer

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Aniebrys Marrero

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

publication date

1 January 2017

1 reference

Sub-cellular biochemistry

19 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

83

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

149-183

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of a snake venom hemorrhagic metalloproteinase by human and rat alpha-macroglobulins

31 May 2020

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Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system

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Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?

21 January 2018

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Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome

21 January 2018

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The properties of rabbit alpha1-macroglobulin upon activation are distinct from those of rabbit and human alpha2-macroglobulins.

21 January 2018

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A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

21 January 2018

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21 January 2018

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The electrophoretically ‘slow’ and ‘fast’ forms of the α2-macroglobulin molecule

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Structural basis for conserved complement factor-like function in the antimalarial protein TEP1.

21 January 2018

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Purification and characterization of a tetrameric alpha-macroglobulin proteinase inhibitor from the gastropod mollusc Biomphalaria glabrata

21 January 2018

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21 January 2018

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Tartrate-resistant acid phosphatase forms complexes with alpha2-macroglobulin in serum.

21 January 2018

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Genome-wide analysis of lipoprotein expression in Escherichia coli MG1655.

21 January 2018

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Bacterial alpha2-macroglobulins: colonization factors acquired by horizontal gene transfer from the metazoan genome?

21 January 2018

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IrAM-An alpha2-macroglobulin from the hard tick Ixodes ricinus: characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes

21 January 2018

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Analysing the eosinophil cationic protein - a clue to the function of the eosinophil granulocyte

21 January 2018

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Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor

21 January 2018

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Purification and characterization of alpha 2-, alpha 2-beta- and beta-macroglobulin inhibitors in the hedgehog, Erinaceus europaeus: beta-macroglobulin identified as the plasma antihemorrhagic factor

21 January 2018

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Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3

21 January 2018

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alpha-Macroglobulins are present in some gram-negative bacteria: characterization of the alpha2-macroglobulin from Escherichia coli

21 January 2018

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The reaction mechanism of the internal thioester in the human complement component C4.

21 January 2018

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Localisation of the major reactive lysine residue involved in the self-crosslinking of proteinase-activated Limulus alpha 2-macroglobulin.

21 January 2018

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JPred4: a protein secondary structure prediction server

21 January 2018

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Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system

21 January 2018

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Identification of α2 macroglobulin as a major serum ghrelin esterase

21 January 2018

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Alpha 2-macroglobulin: a binding protein for transforming growth factor-beta and various cytokines

21 January 2018

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The structure of bovine complement component 3 reveals the basis for thioester function

21 January 2018

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Evolution of thioester-containing proteins revealed by cloning and characterization of their genes from a cnidarian sea anemone, Haliplanella lineate

21 January 2018

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Structure of protease-cleaved Escherichia coli α-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment

21 January 2018

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A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis

21 January 2018

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Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition

21 January 2018

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Human α2-Macroglobulin Is an Osteogenic Growth Peptide-Binding Protein

21 January 2018

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Alpha 2-macroglobulin bait region variants. A role for the bait region in tetramer formation

21 January 2018

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Clostridiopeptidase B inhibition by plasma macroglobulins and microbial antiproteases

21 January 2018

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Purification and characterization of alpha 2-macroglobulin from the white shrimp (Penaeus vannamei).

21 January 2018

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Binding of soluble myelin basic protein to various conformational forms of alpha2-macroglobulin.

21 January 2018

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Human plasma alpha 2-macroglobulin. An inhibitor of plasma kallikrein

21 January 2018

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Purification and characterization of an alpha 2-macroglobulin-like proteinase inhibitor from plasma of the crayfish Pacifastacus leniusculus

21 January 2018

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An overview of proteinase inhibitors

21 January 2018

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Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha 2-macroglobulin. Evidence for two forms differing primarily in their bait region sequences

21 January 2018

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A recombinant bait region mutant of human alpha2-macroglobulin exhibiting an altered proteinase-inhibiting spectrum

21 January 2018

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Molecular cloning of Limulus alpha 2-macroglobulin.

21 January 2018

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Structures of complement component C3 provide insights into the function and evolution of immunity

21 January 2018

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Crystal structure of the receptor-binding domain of alpha 2-macroglobulin

21 January 2018

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Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif

21 January 2018

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Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function

21 January 2018

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The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

21 January 2018

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Characterization of an alpha-macroglobulin-like glycoprotein isolated from the plasma of the soft tick Ornithodoros moubata.

21 January 2018

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Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

21 January 2018

1 reference

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An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice

21 January 2018

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Architecture of native human alpha 2-macroglobulin studied by cryoelectron microscopy and three-dimensional reconstruction

21 January 2018

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Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain

21 January 2018

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21 January 2018

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Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins

21 January 2018

1 reference

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Interleukin 1 beta (IL-1 beta) and the IL-1 beta-alpha 2-macroglobulin complex upregulate the platelet-derived growth factor alpha-receptor on rat pulmonary fibroblasts

21 January 2018

1 reference

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Identification of the high affinity binding site in transforming growth factor-beta involved in complex formation with alpha 2-macroglobulin. Implications regarding the molecular mechanisms of complex formation between alpha 2-macroglobulin and grow

21 January 2018

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Proteases: multifunctional enzymes in life and disease

21 January 2018

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Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

21 January 2018

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The crystal structure of human α2-macroglobulin reveals a unique molecular cage

21 January 2018

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Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex

21 January 2018

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Inhibition of Fusiformis nodosus protease and bovine trypsin by serum alpha macroglobulin

21 January 2018

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Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors

21 January 2018

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Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima

21 January 2018

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Conformational states of a bacterial α2-macroglobulin resemble those of human complement C3.

21 January 2018

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Amino acid sequence of hen ovomacroglobulin (ovostatin) deduced from cloned cDNA.

21 January 2018

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Protein glycosylation in bacteria: sweeter than ever

21 January 2018

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Glycosylation patterns of human alpha2-macroglobulin: analysis of lectin binding by electron microscopy

21 January 2018

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Activated alpha 2-macroglobulin is a principal defensin-binding protein

21 January 2018

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Alpha2-macroglobulin from an Atlantic shrimp: biochemical characterization, sub-cellular localization and gene expression upon fungal challenge.

21 January 2018

1 reference

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Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.

21 January 2018

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Interaction and complex-formation between the eosinophil cationic protein and alpha 2-macroglobulin

21 January 2018

1 reference

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Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity

21 January 2018

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Unique features of a Pseudomonas aeruginosa α2-macroglobulin homolog.

21 January 2018

1 reference

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Nerve growth factor binds to serum alpha-2-macroglobulin

21 January 2018

1 reference

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Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeia

21 January 2018

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Structure of the LDL receptor extracellular domain at endosomal pH

21 January 2018

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Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

21 January 2018

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The plasmin–antiplasmin system: structural and functional aspects

21 January 2018

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Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids

21 January 2018

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Three-dimensional structures of the human α2-macroglobulin-methylamine and chymotrypsin complexes

21 January 2018

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Testing the '+2 rule' for lipoprotein sorting in the Escherichia coli cell envelope with a new genetic selection

21 January 2018

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The conformational state of human alpha 2-macroglobulin influences its dissociation into half-molecules by sodium thiocyanate.

21 January 2018

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Partial primary structure of human pregnancy zone protein: extensive sequence homology with human alpha 2-macroglobulin

21 January 2018

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Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4.

21 January 2018

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Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris

21 January 2018

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Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes

21 January 2018

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Normal and pathological serum levels of alpha2-macroglobulins in men and mice

21 January 2018

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Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein

21 January 2018

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The isolation and partial characterization of alpha 2-macroglobulin from the serum of the ostrich (Struthio camelus

21 January 2018

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Binding of lipoprotein lipase to alpha 2-macroglobulin

21 January 2018

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N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli

21 January 2018

1 reference

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Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region

21 January 2018

1 reference

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The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases

21 January 2018

1 reference

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Neurotrophin binding to human alpha 2-macroglobulin under apparent equilibrium conditions

21 January 2018

1 reference

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Structure of a bacterial α2-macroglobulin reveals mimicry of eukaryotic innate immunity

21 January 2018

1 reference

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Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

21 January 2018

1 reference

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Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin

21 January 2018

1 reference

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Structure of a rat α1-macroglobulin receptor-binding domain dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Isolation and characterization of an alpha-macroglobulin from the gastropod mollusc Helix pomatia with tetrameric structure and preserved activity after methylamine treatment

21 January 2018

1 reference

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An α2-macroglobulinlike activity in the blood of chelicerate and mandibulate arthropods

21 January 2018

1 reference

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Human T cell responses against the major cysteine proteinase (cruzipain) of Trypanosoma cruzi: role of the multifunctional alpha 2- macroglobulin receptor in antigen presentation by monocytes

21 January 2018

1 reference

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Proteinase inhibitory spectrum of mouse murinoglobulin and alpha-macroglobulin

21 January 2018

1 reference

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Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes

31 March 2020

1 reference

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Crystallization of proteins of the alpha 2-macroglobulin superfamily

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP.

31 March 2020

1 reference

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Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism

31 March 2020

1 reference

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The biosynthesis of acute-phase proteins in primary cultures of rat hepatocytes

31 March 2020

1 reference

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Human leptin forms complexes with alpha 2-macroglobulin which are recognized by the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein

31 March 2020

1 reference

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Bait region involvement in the dimer-dimer interface of human alpha 2-macroglobulin and in mediating gross conformational change. Evidence from cysteine variants that form interdimer disulfides

31 March 2020

1 reference

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Mechanism of insulin incorporation into .alpha.2-macroglobulin: implications for the study of peptide and growth factor binding

31 March 2020

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Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids1a,b,c,d

31 March 2020

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Three complement-like repeats compose the complete alpha2-macroglobulin binding site in the second ligand binding cluster of the low density lipoprotein receptor-related protein

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Epidermal growth factor binding to human .alpha.2-macroglobulin. Implications for .alpha.2-macroglobulin-growth factor interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Characterization of functional human .alpha.2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Crystallization and preliminary X-ray diffraction analysis of eukaryotic α2 -macroglobulin family members modified by methylamine, proteases and glycosidases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

NMR solution structure of the receptor binding domain of human alpha(2)-macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Conformational changes of alpha-macroglobulin and ovomacroglobulin from the green turtle (Chelonia mydas japonica)

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

The novel three-dimensional structure of native human alpha 2-macroglobulin and comparisons with the structure of the methylamine derivative

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Three-dimensional structure of the human plasmin alpha2-macroglobulin complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

The three-dimensional structure of the human alpha 2-macroglobulin dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Comparative Binding of Neurotrophins (NT-3, CNTF and NGF) and Various Cytokines to α2-Macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Multiple forms of alpha2-macroglobulin from a bony fish, the common carp (Cyprinus carpio): striking sequence diversity in functional sites

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Alpha 2-macroglobulin conformation determines binding affinity for activin A and plasma clearance of activin A/alpha 2-macroglobulin complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Amniotic fluid embolism: the complication of known pathomechanism but without pathogenetic therapy?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Inhibin, activin and follistatin bind preferentially to the transformed species of alpha 2-macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Dissociation of alpha 2 M-macroglobulin into functional half-molecules by mild acid treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Structural details of proteinase entrapment by human alpha2-macroglobulin emerge from three-dimensional reconstructions of Fab labeled native, half-transformed, and transformed molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

The structure of the C949S mutant human alpha(2)-macroglobulin demonstrates the critical role of the internal thiol esters in its proteinase-entrapping structural transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Role of Internal Thiol Esters in the α‐Macroglobulin‐Proteinase Binding Mechanisma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Evolution of alpha 2-macroglobulin. The demonstration in a variety of vertebrate species of a protein resembling human alpha 2-macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Critical Role of Asparagine 1065 of Human α2-Macroglobulin in Formation and Reactivity of the Thiol Ester

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Complexes between insulin-like growth factor binding proteins and alpha-2-macroglobulin in patients with tumor

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Design of a new protease inhibitor by the manipulation of the bait region of alpha 2-macroglobulin: inhibition of the tobacco etch virus protease by mutant alpha 2-macroglobulin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

Highly efficient inhibition of human chymase by alpha(2)-macroglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-46503-6_6

10.1007/978-3-319-46503-6_6

31 March 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28271476%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference