Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin (Q33665370)

24799681

28 July 2017

title

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin (English)

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28 July 2017

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1

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2 June 2020

Mark R. Wilson

5

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2 June 2020

2

Janet R Kumita

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2 June 2020

author name string

Richard W Mifsud

3

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2 June 2020

Cherrie A Gooden

4

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2 June 2020

Christopher M Dobson

6

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2 June 2020

language of work or name

English

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publication date

5 May 2014

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24799681

Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

published in

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2 June 2020

volume

111

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2 June 2020

issue

20

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2 June 2020

page(s)

E2081-90

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Molecular chaperone functions in protein folding and proteostasis

2 June 2020

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils.

21 June 2018

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21 June 2018

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21 June 2018

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The oxidant hypochlorite (OCl−), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate

21 June 2018

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39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Heat-induced fragmentation of human alpha 2-macroglobulin

21 June 2018

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Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

21 June 2018

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Inhibition of β2-Microglobulin Amyloid Fibril Formation by α2-Macroglobulin

21 January 2018

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The subunits of alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein, native and transformed alpha2-macroglobulin and interleukin 6 in Alzheimer's disease

21 January 2018

1 reference

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3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome

21 January 2018

1 reference

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Effects of oxidized fibrinogen on the functions of blood cells, blood clotting, and rheology.

21 January 2018

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Neurodegenerative diseases and oxidative stress

21 January 2018

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Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes

21 January 2018

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Aggregates of denatured proteins stimulate nitric oxide and superoxide production in macrophages

21 January 2018

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The Acid Ionization Constant of HOCl from 5 to 35°

21 January 2018

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Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

21 January 2018

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Generation of IgG aggregates by the myeloperoxidase-hydrogen peroxide system

30 October 2018

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Oxidized low-density lipoprotein induces macrophage respiratory burst via its protein moiety: A novel pathway in atherogenesis?

30 October 2018

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12 December 2020

Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha 2-macroglobulin

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12 December 2020

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin

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12 December 2020

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

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12 December 2020

Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers

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12 December 2020

Alpha-crystallin can act as a chaperone under conditions of oxidative stress

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12 December 2020

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

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12 December 2020

Myeloperoxidase and oxidative stress in rheumatoid arthritis

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12 December 2020

The contact zones in human alpha2-macroglobulin--functional domains important for the regulation of the trapping mechanism

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12 December 2020

The Binding of Receptor-recognized α2-Macroglobulin to the Low Density Lipoprotein Receptor-related Protein and the α2M Signaling Receptor Is Decoupled by Oxidation

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12 December 2020

Bait region involvement in the dimer-dimer interface of human alpha 2-macroglobulin and in mediating gross conformational change. Evidence from cysteine variants that form interdimer disulfides

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Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure

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Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro

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Identifiers

DOI

10.1073/PNAS.1403379111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

24799681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json