EGF receptor family: twisting targets for improved cancer therapies (Q39228711)

10 September 2017

title

EGF receptor family: twisting targets for improved cancer therapies (English)

1 reference

10 September 2017

2

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10 June 2020

Ronit Pinkas-Kramarski

6

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10 June 2020

author name string

Antony W Burgess

1

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10 June 2020

Nancy E Hynes

3

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10 June 2020

Thomas Jovin

4

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10 June 2020

Alexander Levitzki

5

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10 June 2020

Yosef Yarden

7

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10 June 2020

publication date

18 March 2014

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10 September 2017

published in

Growth Factors Journal

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10 June 2020

volume

32

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10 June 2020

issue

2

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10 June 2020

page(s)

74-81

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Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

10 June 2020

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RabGEFs are a major determinant for specific Rab membrane targeting

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Regulation of human EGF receptor by lipids

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Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope

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Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling

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Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis

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Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy

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Loss of Memo, a novel FGFR regulator, results in reduced lifespan

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Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.

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Lysine 63-linked polyubiquitination is required for EGF receptor degradation

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Oncogenic ERBB3 mutations in human cancers

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Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2

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MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor

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Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2

21 January 2018

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Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose.

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Network quantification of EGFR signaling unveils potential for targeted combination therapy.

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Exploring higher-order EGFR oligomerisation and phosphorylation--a combined experimental and theoretical approach

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Piecing together the extracellular puzzle

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Immuno-PET quantitation of de2-7 epidermal growth factor receptor expression in glioma using 124I-IMP-R4-labeled antibody ch806.

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A single ligand is sufficient to activate EGFR dimers

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Macromolecular juggling by ubiquitylation enzymes

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The epidermal growth factor receptor and its ligands in cardiovascular disease

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Memo mediates ErbB2-driven cell motility.

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Endocytosis and cancer

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Personalizing oncology: perspectives and prospects

21 January 2018

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Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching.

21 January 2018

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When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

21 January 2018

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Dual targeting of HER2-positive cancer with trastuzumab emtansine and pertuzumab: critical role for neuregulin blockade in antitumor response to combination therapy.

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The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor

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Automated multidimensional single molecule fluorescence microscopy feature detection and tracking.

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MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth

21 January 2018

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Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

21 January 2018

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Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death

21 January 2018

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Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy

21 January 2018

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Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes.

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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.

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LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor

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Targeted cancer immunotherapy

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