The MET axis as a therapeutic target (Q24609682)

22 June 2017

title

The MET axis as a therapeutic target (English)

1 reference

22 June 2017

2

Ravi Salgia

1 reference

22 June 2017

Martin Sattler

1

1 reference

22 June 2017

publication date

1 April 2009

1 reference

Update on Cancer Therapeutics

22 June 2017

published in

1 reference

22 June 2017

volume

3

1 reference

22 June 2017

issue

3

1 reference

22 June 2017

page(s)

109-118

1 reference

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

22 June 2017

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A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor

7 April 2017

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Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase

7 April 2017

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

7 April 2017

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

7 April 2017

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7 April 2017

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Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion

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A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo

7 April 2017

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Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

7 April 2017

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A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo

7 April 2017

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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

7 April 2017

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K252a inhibits the oncogenic properties of Met, the HGF receptor

7 April 2017

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

7 April 2017

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

7 April 2017

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Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development

7 April 2017

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

7 April 2017

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Met receptor tyrosine kinase: enhanced signaling through adapter proteins

7 April 2017

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Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase

7 April 2017

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

7 April 2017

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Scatter factor/hepatocyte growth factor is essential for liver development

7 April 2017

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

7 April 2017

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

7 April 2017

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Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase

7 April 2017

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Expression and mutational analysis of MET in human solid cancers

7 April 2017

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Cell cycle regulation by oncogenic tyrosine kinases in myeloid neoplasias: from molecular redox mechanisms to health implications

27 September 2017

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A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras

27 September 2017

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C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes

27 September 2017

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High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

27 September 2017

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Preclinical efficacy of the c-Met inhibitor CE-355621 in a U87 MG mouse xenograft model evaluated by 18F-FDG small-animal PET.

27 September 2017

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AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts

27 September 2017

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NK4 gene therapy targeting HGF-Met and angiogenesis.

27 September 2017

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An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms

27 September 2017

1 reference

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c-Met is a potentially new therapeutic target for treatment of human melanoma

27 September 2017

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Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival

27 September 2017

1 reference

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A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

27 September 2017

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EGFR targeting therapies: monoclonal antibodies versus tyrosine kinase inhibitors. Similarities and differences.

27 September 2017

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Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

MicroRNAs and the hallmarks of cancer

27 September 2017

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Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

MET overexpression turns human primary osteoblasts into osteosarcomas.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Structural basis of hepatocyte growth factor/scatter factor and MET signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma

27 September 2017

1 reference

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Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation

27 September 2017

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Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML).

27 September 2017

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Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion

27 September 2017

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RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival

27 September 2017

1 reference

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The odd couple: signal transduction and endocytosis

27 September 2017

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c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions

27 September 2017

1 reference

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

27 September 2017

1 reference

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A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase

27 September 2017

1 reference

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Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.

27 September 2017

1 reference

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Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

27 September 2017

1 reference

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

A novel germ line juxtamembrane Met mutation in human gastric cancer

27 September 2017

1 reference

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Activation of hepatocyte growth factor-met autocrine loop enhances tumorigenicity in a human lung adenocarcinoma cell line.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells

27 September 2017

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The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network

27 September 2017

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Hepatocyte growth factor, a versatile signal for developing neurons

27 September 2017

1 reference

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Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

The mutationally activated Met receptor mediates motility and metastasis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Molecular abnormalities in lung cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Met and hepatocyte growth factor/scatter factor expression in human gliomas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

27 September 2017

1 reference

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Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma

27 September 2017

1 reference

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Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

An 11-amino acid sequence from c-met initiates epithelial chemotaxis via phosphatidylinositol 3-kinase and phospholipase C.

27 September 2017

1 reference

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The HGF receptor family: unconventional signal transducers for invasive cell growth

27 September 2017

1 reference

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Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Identification of a novel germline MET mutation in dogs.

30 May 2018

1 reference

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Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Structural and functional domains critical for constitutive activation of the HGF-receptor (Met).

30 May 2018

1 reference

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A Prospective Study of Congenital Cytomegalovirus Infection in Japan

30 May 2018

1 reference

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Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure

30 May 2018

1 reference

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Purification and subunit structure of hepatocyte growth factor from rat platelets

30 May 2018

1 reference

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

30 May 2018

1 reference

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Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung

28 November 2018

1 reference

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Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis.

28 November 2018

1 reference

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The Sema domain of Met is necessary for receptor dimerization and activation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847295

Down-regulation of MET, the receptor for hepatocyte growth factor.

28 November 2018

1 reference

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Molecular cloning of a new transforming gene from a chemically transformed human cell line.

28 November 2018

1 reference

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The clinical significance of hepatocyte growth factor for non-small cell lung cancer

28 November 2018

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A role for common fragile site induction in amplification of human oncogenes

7 January 2021

1 reference

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A Peptide Representing the Carboxyl-terminal Tail of the Met Receptor Inhibits Kinase Activity and Invasive Growth

7 January 2021

1 reference

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HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.UCT.2009.01.001

Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.UCT.2009.01.001

Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer

7 January 2021

1 reference

12 December 2020

Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model

1 reference

12 December 2020

Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model

1 reference

12 December 2020

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit

1 reference

12 December 2020

10.1016/J.UCT.2009.01.001

Identifiers

DOI

1 reference

OpenCitations bibliographic resource ID

22 June 2017

4905141

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4905141

1 reference