Emerging links among Chromosome Instability (CIN), cancer, and aging (Q38929880)

7 September 2017

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title

Emerging links among Chromosome Instability (CIN), cancer, and aging (English)

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7 September 2017

Chinthalapally V Rao

1

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7 September 2017

Adam S Asch

series ordinal

2

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7 September 2017

Hiroshi Y Yamada

series ordinal

3

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7 September 2017

publication date

17 August 2016

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7 September 2017

published in

Molecular Carcinogenesis

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7 September 2017

volume

56

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7 September 2017

issue

3

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7 September 2017

page(s)

791-803

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Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris

7 September 2017

cites work

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

21 January 2018

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Revisiting tumour aneuploidy - the place of ploidy assessment in the molecular era.

21 January 2018

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The mitotic origin of chromosomal instability

21 January 2018

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Microsatellite instability in colorectal cancer: clinicopathological significance

21 January 2018

1 reference

Microsatellite instability: an update

21 January 2018

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Causes and consequences of microsatellite instability in gastric carcinogenesis.

21 January 2018

1 reference

Replication stress links structural and numerical cancer chromosomal instability

21 January 2018

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Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.

21 January 2018

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The genomic landscapes of human breast and colorectal cancers

21 January 2018

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Genomic instability and colon carcinogenesis: from the perspective of genes

21 January 2018

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Patterns of genomic instability in gastric cancer: clinical implications and perspectives

21 January 2018

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Comprehensive molecular characterization of gastric adenocarcinoma

21 January 2018

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Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability

21 January 2018

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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

21 January 2018

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Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection

21 January 2018

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HBxAPα/Rsf-1-mediated HBx-hBubR1 interactions regulate the mitotic spindle checkpoint and chromosome instability.

21 January 2018

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HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint.

21 January 2018

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Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation

21 January 2018

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Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

21 January 2018

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Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice

21 January 2018

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Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

21 January 2018

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Centrosome clustering and chromosomal (in)stability: A matter of life and death

21 January 2018

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DNA breaks and chromosome pulverization from errors in mitosis

21 January 2018

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Chromothripsis from DNA damage in micronuclei.

21 January 2018

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Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

21 January 2018

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Cellular senescence and tumor suppressor gene p16

21 January 2018

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Cellular senescence and aging: the role of B-MYB

21 January 2018

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DNA damage checkpoint recovery and cancer development

21 January 2018

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The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

21 January 2018

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A multi-targeted approach to suppress tumor-promoting inflammation

21 January 2018

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Chronic inflammation and cytokines in the tumor microenvironment

21 January 2018

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Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence

21 January 2018

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Ink4a/Arf expression is a biomarker of aging

21 January 2018

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Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

21 January 2018

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

21 January 2018

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p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

21 January 2018

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p21WAF1 and tumourigenesis: 20 years after

21 January 2018

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Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis.

21 January 2018

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The function of p27 KIP1 during tumor development.

21 January 2018

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

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Cellular senescence: from physiology to pathology

21 January 2018

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NKG2D ligands mediate immunosurveillance of senescent cells

21 January 2018

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Cellular senescence: from growth arrest to immunogenic conversion

21 January 2018

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Immune surveillance of unhealthy cells by natural killer cells

21 January 2018

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Consensus guidelines for the detection of immunogenic cell death

21 January 2018

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Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

21 January 2018

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Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

21 January 2018

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Identification of aneuploidy-selective antiproliferation compounds

21 January 2018

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Aneuploidy-induced cellular stresses limit autophagic degradation

21 January 2018

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Detectable clonal mosaicism from birth to old age and its relationship to cancer

21 January 2018

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Common genetic and epigenetic syndromes

21 January 2018

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Copy number variants, aneuploidies, and human disease

21 January 2018

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Transcriptional consequences of aneuploidy

21 January 2018

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Unstable genomes elevate transcriptome dynamics

21 January 2018

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Chromosomal instability and transcriptome dynamics in cancer

21 January 2018

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A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis

21 January 2018

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Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

21 January 2018

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Aneuploidy causes premature differentiation of neural and intestinal stem cells

21 January 2018

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A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect

21 January 2018

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JNK signaling is needed to tolerate chromosomal instability

21 January 2018

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Chromosomal instability causes sensitivity to metabolic stress.

21 January 2018

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Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.

21 January 2018

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Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.

21 January 2018

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TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.

21 January 2018

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Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human

21 January 2018

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

21 January 2018

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Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells

21 January 2018

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Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

21 January 2018

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Aneuploidy in health, disease, and aging

21 January 2018

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CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us?

21 January 2018

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Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice

21 January 2018

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Whole chromosome instability and cancer: a complex relationship

21 January 2018

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Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

21 January 2018

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Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model

21 January 2018

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Structure of an intermediate conformer of the spindle checkpoint protein Mad2

21 January 2018

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Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

21 January 2018

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Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

21 January 2018

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MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

21 January 2018

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Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells

21 January 2018

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Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

21 January 2018

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Polyploidy can drive rapid adaptation in yeast

21 January 2018

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Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap

21 January 2018

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Chromosomal Instability (CIN) Phenotype, CIN High or CIN Low, Predicts Survival for Colorectal Cancer

21 January 2018

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Chromosomal instability as a prognostic marker in cervical cancer

21 January 2018

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Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

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Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

21 January 2018

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Epidermal development, growth control, and homeostasis in the face of centrosome amplification

21 January 2018

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Chronic centrosome amplification without tumorigenesis

21 January 2018

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Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.

21 January 2018

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BUBR1 deficiency results in abnormal megakaryopoiesis

21 January 2018

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Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

21 January 2018

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BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

21 January 2018

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BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

21 January 2018

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Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation

21 January 2018

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

21 January 2018

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

21 January 2018

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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

21 January 2018

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BubR1 kinase: protection against aneuploidy and premature aging

21 January 2018

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Mammalian sirtuins: biological insights and disease relevance

21 January 2018

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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

21 January 2018

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Spartan deficiency causes genomic instability and progeroid phenotypes

21 January 2018

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Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

21 January 2018

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Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model

21 January 2018

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Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.

21 January 2018

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Senescence-associated inflammatory responses: aging and cancer perspectives

21 January 2018

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Senescent cells: SASPected drivers of age-related pathologies

21 January 2018

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Cellular senescence and its effector programs

21 January 2018

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The senescence-associated secretory phenotype: the dark side of tumor suppression

21 January 2018

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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

21 January 2018

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Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.

21 January 2018

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Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype

21 January 2018

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Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

21 January 2018

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

21 January 2018

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

21 January 2018

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Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

21 January 2018

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Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

21 January 2018

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Rapamycin extends murine lifespan but has limited effects on aging

21 January 2018

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Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence

21 January 2018

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Longevity, aging and rapamycin

21 January 2018

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Cancer immunotherapy: the beginning of the end of cancer?

21 January 2018

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The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

21 January 2018

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The Basis of Oncoimmunology

21 January 2018

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Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

21 January 2018

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Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

21 January 2018

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Immune checkpoint therapy for non-small-cell lung cancer: an update

21 January 2018

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Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology

21 January 2018

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Cellular senescence impact on immune cell fate and function

21 January 2018

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Granule exocytosis mediates immune surveillance of senescent cells.

21 January 2018

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

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Failure of cell cleavage induces senescence in tetraploid primary cells

21 January 2018

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The inner centromere-shugoshin network prevents chromosomal instability.

21 January 2018

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Sgo1 is a potential therapeutic target for hepatocellular carcinoma

21 January 2018

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SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers

21 January 2018

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Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer

21 January 2018

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Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice

21 January 2018

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Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung

21 January 2018

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Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation

21 January 2018

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Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.22539

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7 September 2017

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