Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models (Q38891157)

3 June 2018

review article

1 reference

title

Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models (English)

1 reference

3 June 2018

0 references

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1 reference

Elizabeth E Spangenberg

series ordinal

1

1 reference

3 June 2018

Kim N Green

series ordinal

2

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3 June 2018

language of work or name

1 reference

6 July 2016

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3 June 2018

Brain, Behavior, and Immunity

published in

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3 June 2018

volume

61

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3 June 2018

page(s)

1-11

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3 June 2018

IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.

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Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease

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Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease

17 June 2018

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Genetics ignite focus on microglial inflammation in Alzheimer's disease

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

17 June 2018

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Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

17 June 2018

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Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice

17 June 2018

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ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

17 June 2018

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Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

17 June 2018

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Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

17 June 2018

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Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.

17 June 2018

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NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

17 June 2018

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Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease

17 June 2018

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

17 June 2018

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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model

17 June 2018

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

17 June 2018

1 reference

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

17 June 2018

1 reference

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

17 June 2018

1 reference

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IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

17 June 2018

1 reference

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Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

17 June 2018

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Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models.

17 June 2018

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Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia.

17 June 2018

1 reference

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

17 June 2018

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Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

17 June 2018

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Microglial phagocytosis of live neurons

17 June 2018

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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.

17 June 2018

1 reference

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

17 June 2018

1 reference

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Microglia actions in Alzheimer’s disease.

17 June 2018

1 reference

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

17 June 2018

1 reference

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Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior

17 June 2018

1 reference

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Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer's disease model

17 June 2018

1 reference

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Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

17 June 2018

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Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease.

17 June 2018

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Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

17 June 2018

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Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

17 June 2018

1 reference

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

17 June 2018

1 reference

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TREM2 Variants in Alzheimer's Disease

17 June 2018

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Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

17 June 2018

1 reference

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IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

17 June 2018

1 reference

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Information processing during phagocytosis

17 June 2018

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Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

17 June 2018

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

17 June 2018

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

17 June 2018

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Synaptic pruning by microglia is necessary for normal brain development

17 June 2018

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Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

17 June 2018

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

17 June 2018

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

17 June 2018

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17 June 2018

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Microglial interactions with synapses are modulated by visual experience

17 June 2018

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Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline

17 June 2018

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Fate mapping analysis reveals that adult microglia derive from primitive macrophages

17 June 2018

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

17 June 2018

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Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis

17 June 2018

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Microglial activation and chronic neurodegeneration

17 June 2018

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Microglia and neuroprotection: from in vitro studies to therapeutic applications

17 June 2018

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Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation

17 June 2018

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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

17 June 2018

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

17 June 2018

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

17 June 2018

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

17 June 2018

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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

17 June 2018

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IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase

17 June 2018

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Alternative activation of macrophages: immune function and cellular biology

17 June 2018

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Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship

17 June 2018

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Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

17 June 2018

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

17 June 2018

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Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

17 June 2018

1 reference

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No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial

17 June 2018

1 reference

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

17 June 2018

1 reference

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

PirB restricts ocular-dominance plasticity in visual cortex.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

17 June 2018

1 reference

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Evaluating triggers and enhancers of tau fibrillization.

17 June 2018

1 reference

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Alzheimer Disease in the US Population

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Microglia as neuroprotective, immunocompetent cells of the CNS.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

17 June 2018

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

17 June 2018

1 reference

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Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

17 June 2018

1 reference

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Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

17 June 2018

1 reference

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Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging

17 June 2018

1 reference

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Inflammation and Alzheimer's disease

17 June 2018

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Microglial response to amyloid plaques in APPsw transgenic mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

CSF1 overexpression has pleiotropic effects on microglia in vivo

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [¹¹C]DAA1106.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Spreading of neurodegenerative pathology via neuron-to-neuron transmission of β-amyloid.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

In-vivo measurement of activated microglia in dementia

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

The cytoskeleton in Alzheimer disease.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde".

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218993

[11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease

22 August 2018

1 reference

12 December 2020

A new method for removal of mononuclear phagocytes from heterogeneous cell populations in vitro, using the liposome-mediated macrophage 'suicide' technique

1 reference

12 December 2020

3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid

1 reference

12 December 2020

Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

1 reference

12 December 2020

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

1 reference

12 December 2020

Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex

1 reference

12 December 2020

10.1016/J.BBI.2016.07.003

Identifiers

DOI

1 reference

3 June 2018

PMC publication ID

5218993

1 reference

3 June 2018

PubMed publication ID

27395435

1 reference

3 June 2018