The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update (Q38837451)

6 September 2017

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title

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update (English)

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6 September 2017

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Meng-Chen Lu

series ordinal

1

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6 June 2020

Jian-Ai Ji

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Qi-Dong You

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

18 May 2016

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Medicinal Research Reviews

6 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

36

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

5

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6 June 2020

page(s)

924-963

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

Oxidants, oxidative stress and the biology of ageing

6 June 2020

cites work

1 reference

Neurodegenerative diseases and oxidative stress

21 January 2018

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Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory

21 January 2018

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

21 January 2018

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Ageing, oxidative stress and cancer: paradigms in parallax

21 January 2018

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Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

21 January 2018

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Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

21 January 2018

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Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

21 January 2018

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Small molecule modulators of antioxidant response pathway

21 January 2018

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NRF2 and cancer: the good, the bad and the importance of context.

21 January 2018

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Modulation of oxidative stress as an anticancer strategy

21 January 2018

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Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

21 January 2018

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Keap calm, and carry on covalently

21 January 2018

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Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

21 January 2018

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Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction.

21 January 2018

1 reference

Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

21 January 2018

1 reference

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

21 January 2018

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BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress

21 January 2018

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Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

21 January 2018

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Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

21 January 2018

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

21 January 2018

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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

21 January 2018

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Linking oxidative stress to inflammation: Toll-like receptors

21 January 2018

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Oxidative stress, inflammation, and cancer: how are they linked?

21 January 2018

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Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

21 January 2018

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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Nrf2 is essential for protection against acute pulmonary injury in mice

21 January 2018

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Role of NRF2 in protection against hyperoxic lung injury in mice

21 January 2018

1 reference

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

21 January 2018

1 reference

Discovery of the negative regulator of Nrf2, Keap1: a historical overview

21 January 2018

1 reference

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

21 January 2018

1 reference

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

21 January 2018

1 reference

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

21 January 2018

1 reference

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

21 January 2018

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Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

21 January 2018

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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

21 January 2018

1 reference

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

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Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

21 January 2018

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Monitoring Keap1-Nrf2 interactions in single live cells

21 January 2018

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

21 January 2018

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Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

21 January 2018

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The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

21 January 2018

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Nrf2, a multi-organ protector?

21 January 2018

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The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

21 January 2018

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Nrf2: friend or foe for chemoprevention?

21 January 2018

1 reference

The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer

21 January 2018

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Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

21 January 2018

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Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

21 January 2018

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Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane

21 January 2018

1 reference

The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?

21 January 2018

1 reference

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

21 January 2018

1 reference

Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation Study

21 January 2018

1 reference

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

21 January 2018

1 reference

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

21 January 2018

1 reference

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

21 January 2018

1 reference

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

21 January 2018

1 reference

Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis

21 January 2018

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The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy

21 January 2018

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Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?

21 January 2018

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The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease

21 January 2018

1 reference

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.

21 January 2018

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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

21 January 2018

1 reference

Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra

21 January 2018

1 reference

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

21 January 2018

1 reference

The extinguished BEACON of bardoxolone: not a Monday morning quarterback story

21 January 2018

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Molecular basis of the Keap1-Nrf2 system.

21 January 2018

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Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.

21 January 2018

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Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

21 January 2018

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Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases

21 January 2018

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Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.

21 January 2018

1 reference

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

21 January 2018

1 reference

Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway

21 January 2018

1 reference

Reactive oxygen species have a causal role in multiple forms of insulin resistance

21 January 2018

1 reference

Diabetes, oxidative stress and therapeutic strategies

21 January 2018

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The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes

21 January 2018

1 reference

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

21 January 2018

1 reference

Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity

21 January 2018

1 reference

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats

21 January 2018

1 reference

Global and societal implications of the diabetes epidemic

21 January 2018

1 reference

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

21 January 2018

1 reference

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease

21 January 2018

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Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

21 January 2018

1 reference

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

21 January 2018

1 reference

ROS Acts as a Double-Edged Sword in the Pathogenesis of Type 2 Diabetes Mellitus: Is Nrf2 a Potential Target for the Treatment?

21 January 2018

1 reference

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

21 January 2018

1 reference

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice

21 January 2018

1 reference

NQO1 rs1800566 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population

21 January 2018

1 reference

Nrf2 protects against airway disorders

21 January 2018

1 reference

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction

21 January 2018

1 reference

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

21 January 2018

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Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema

21 January 2018

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Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

21 January 2018

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Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease

21 January 2018

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Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

21 January 2018

1 reference

Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking

21 January 2018

1 reference

Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction

21 January 2018

1 reference

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

21 January 2018

1 reference

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease.

21 January 2018

1 reference

The acute respiratory distress syndrome

21 January 2018

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Conditional Deletion of Nrf2 in Airway Epithelium Exacerbates Acute Lung Injury and Impairs the Resolution of Inflammation

21 January 2018

1 reference

Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice

21 January 2018

1 reference

The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice

21 January 2018

1 reference

The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice

21 January 2018

1 reference

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

21 January 2018

1 reference

Regulation of Nrf2-an update

21 January 2018

1 reference

Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy

21 January 2018

1 reference

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney

21 January 2018

1 reference

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

21 January 2018

1 reference

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

21 January 2018

1 reference

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

21 January 2018

1 reference

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

21 January 2018

1 reference

Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO

21 January 2018

1 reference

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

21 January 2018

1 reference

Discovery of a potential anti-inflammatory agent: 3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile

21 January 2018

1 reference

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

21 January 2018

1 reference

Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy

21 January 2018

1 reference

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

Cullin3-BTB interface: a novel target for stapled peptides

21 January 2018

1 reference

Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments

21 January 2018

1 reference

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

21 January 2018

1 reference

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.

21 January 2018

1 reference

Natural product inhibitors of the ubiquitin-proteasome pathway

21 January 2018

1 reference

Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance

21 January 2018

1 reference

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.

21 January 2018

1 reference

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

21 January 2018

1 reference

Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review

21 January 2018

1 reference

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction

21 January 2018

1 reference

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models.

21 January 2018

1 reference

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

21 January 2018

1 reference

Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor

21 January 2018

1 reference

Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex

21 January 2018

1 reference

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

21 January 2018

1 reference

Chemistry: Chemical con artists foil drug discovery

21 January 2018

1 reference

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis

21 January 2018

1 reference

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

21 January 2018

1 reference

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.

21 January 2018

1 reference

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

21 January 2018

1 reference

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

21 January 2018

1 reference

Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation.

21 January 2018

1 reference

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling

21 January 2018

1 reference

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

21 January 2018

1 reference

Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line

21 January 2018

1 reference

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs.

21 January 2018

1 reference

Keap1-Nrf2 signalling in pancreatic cancer

21 January 2018

1 reference

A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer

21 January 2018

1 reference

An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses.

21 January 2018

1 reference

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

21 January 2018

1 reference

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.

21 January 2018

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Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.

21 January 2018

1 reference

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

21 January 2018

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

21 January 2018

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21 January 2018

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Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

21 January 2018

1 reference

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

21 January 2018

1 reference

Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells

21 January 2018

1 reference

Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin

21 January 2018

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Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells

21 January 2018

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Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

21 January 2018

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A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity

21 January 2018

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

21 January 2018

1 reference

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

21 January 2018

1 reference

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

21 January 2018

1 reference

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

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Managing the challenge of chemically reactive metabolites in drug development.

21 January 2018

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Idiosyncratic drug reactions: past, present, and future

21 January 2018

1 reference

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

21 January 2018

1 reference

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

21 January 2018

1 reference

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

21 January 2018

1 reference

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

21 January 2018

1 reference

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

21 January 2018

1 reference

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

21 January 2018

1 reference

Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy.

21 January 2018

1 reference

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

21 January 2018

1 reference

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway.

21 January 2018

1 reference

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

21 January 2018

1 reference

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase

21 January 2018

1 reference

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1242/JCS.074286

Identifiers

DOI

10.1002/MED.21396

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192495%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference