Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. (Q36144939)

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23 February 2020

title

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators (English)

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23 February 2020

1

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23 February 2020

Andrew D. Mesecar

9

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23 February 2020

Terry W. Moore

11

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23 February 2020

author name string

Haranatha Potteti

2

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23 February 2020

Benjamin G Richardson

3

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23 February 2020

Laura Kingsley

4

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23 February 2020

Julia P Luciano

5

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23 February 2020

Aya F Ryuzoji

6

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23 February 2020

Hyun Lee

7

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23 February 2020

Aleksej Krunic

8

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23 February 2020

Sekhar P Reddy

10

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23 February 2020

publication date

4 September 2015

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European Journal of Medicinal Chemistry

23 February 2020

published in

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23 February 2020

volume

103

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23 February 2020

page(s)

252-268

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Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

23 February 2020

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2 October 2017

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Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.

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Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination

2 October 2017

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Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR

2 October 2017

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Modification of keap1 cysteine residues by sulforaphane

2 October 2017

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Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

2 October 2017

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Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance

2 October 2017

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Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

2 October 2017

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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

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2 October 2017

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2 October 2017

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol

2 October 2017

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

2 October 2017

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

2 October 2017

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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

2 October 2017

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2 October 2017

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2 October 2017

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2 July 2018

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Keap calm, and carry on covalently

2 July 2018

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Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

23 September 2018

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Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.

23 September 2018

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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

23 September 2018

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12 December 2020

Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress

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A new short synthesis of 3-substituted 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (amino-CBIs)

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Evaluation of hydrogen bonding complementarity between a secondary sulfonamide and an alpha-amino acid residue

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Effect of sulfonyl protecting groups on the neighboring group participation ability of sulfonamido nitrogen

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10.1016/J.EJMECH.2015.08.049

Identifiers

DOI

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23 February 2020

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23 February 2020

PubMed publication ID

26363505

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26363505%20AND%20SRC:MED&resulttype=core&format=json