Molecular mechanisms of curcumin action: gene expression (Q38045211)

27 August 2017

title

Molecular mechanisms of curcumin action: gene expression (English)

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27 August 2017

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Shishir Shishodia

1

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27 August 2017

publication date

20 September 2012

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27 August 2017

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27 August 2017

volume

39

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27 August 2017

issue

1

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27 August 2017

page(s)

37-55

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Curcumin: getting back to the roots.

27 August 2017

cites work

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Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

21 January 2018

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Curcumin: the Indian solid gold

21 January 2018

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Antioxidant and anti-inflammatory properties of curcumin

21 January 2018

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Curcumin and cancer: an "old-age" disease with an "age-old" solution

21 January 2018

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Molecular targets of curcumin

21 January 2018

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Molecular targets of dietary agents for prevention and therapy of cancer

21 January 2018

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AP-1 function and regulation

21 January 2018

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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

21 January 2018

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Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin

21 January 2018

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ATF3 gene. Genomic organization, promoter, and regulation

21 January 2018

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Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells

21 January 2018

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Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling.

21 January 2018

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Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells

21 January 2018

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Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.

21 January 2018

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Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells.

21 January 2018

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Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling

21 January 2018

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Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

21 January 2018

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Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300.

21 January 2018

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C/EBP and DEK coordinately regulate myeloid differentiation

21 January 2018

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Restoration of C/EBPα in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis

21 January 2018

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Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression

21 January 2018

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Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice

21 January 2018

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Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion

21 January 2018

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Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

21 January 2018

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Induction of apoptosis by curcumin in murine myelomonocytic leukemia WEHI-3 cells is mediated via endoplasmic reticulum stress and mitochondria-dependent pathways.

21 January 2018

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Curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded N-CoR protein

21 January 2018

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CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation

21 January 2018

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p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression

21 January 2018

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Coffee, broccoli and spices are strong inducers of electrophile response element‐dependent transcription in vitro and in vivo – Studies in electrophile response element transgenic mice

21 January 2018

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Curcumin, a medicinal herbal compound capable of inducing the heat shock response

21 January 2018

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Induction of heat shock response by curcumin in human leukemia cells

21 January 2018

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Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas

21 January 2018

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Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas

21 January 2018

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Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling

21 January 2018

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Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling

21 January 2018

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Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress

21 January 2018

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Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

21 January 2018

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Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

21 January 2018

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The GI-GPx gene is a target for Nrf2

21 January 2018

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Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

21 January 2018

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Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages

21 January 2018

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Nuclear factor-kappaB: the enemy within

21 January 2018

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Series introduction: the transcription factor NF-kappaB and human disease

21 January 2018

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

21 January 2018

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Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

21 January 2018

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Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia

21 January 2018

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Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo

21 January 2018

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Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

21 January 2018

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Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.

21 January 2018

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Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

21 January 2018

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Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells

21 January 2018

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Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.

21 January 2018

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Inhibition of NF-kappa B activation can attenuate ischemia/reperfusion-induced contractility impairment via decreasing cardiomyocytic proinflammatory gene up-regulation and matrix metalloproteinase expression

21 January 2018

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The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection

21 January 2018

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Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth

21 January 2018

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Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.

21 January 2018

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The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma

21 January 2018

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STATs and Gene Regulation

21 January 2018

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

21 January 2018

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Stat3 activation is required for cellular transformation by v-src

21 January 2018

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

21 January 2018

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Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

21 January 2018

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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

21 January 2018

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Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia

21 January 2018

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Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway

21 January 2018

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Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes

21 January 2018

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Curcumin inhibits WT1 gene expression in human leukemic K562 cells.

21 January 2018

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Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells.

21 January 2018

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Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells

21 January 2018

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Inhibitory mechanism of pure curcumin on Wilms' tumor 1 (WT1) gene expression through the PKCα signaling pathway in leukemic K562 cells.

21 January 2018

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Therapeutic potential of curcumin in human prostate cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells

21 January 2018

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Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells

21 January 2018

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Development of novel CXCR4-based therapeutics

21 January 2018

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Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4.

21 January 2018

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Curcumin modulates SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells (HRECs).

21 January 2018

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Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.

21 January 2018

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Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model

21 January 2018

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Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling

21 January 2018

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Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.

21 January 2018

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Targeting epidermal growth factor receptor signaling in the treatment of head and neck cancer

21 January 2018

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Copper modulates activities of genistein, nitric oxide, and curcumin in breast tumor cells

21 January 2018

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Curcumin exerts multiple suppressive effects on human breast carcinoma cells

21 January 2018

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 January 2018

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Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

21 January 2018

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Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation

21 January 2018

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Curcumin blocks activation of pancreatic stellate cells

21 January 2018

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Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways

21 January 2018

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Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells

21 January 2018

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Curcumin inhibits transforming growth factor-beta activity via inhibition of Smad signaling in HK-2 cells.

21 January 2018

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Molecular mechanisms of anti-angiogenic effect of curcumin

21 January 2018

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Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

21 January 2018

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Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors

21 January 2018

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Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation

21 January 2018

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Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor.

21 January 2018

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The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis

21 January 2018

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Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells

21 January 2018

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Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

21 January 2018

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Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells

21 January 2018

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Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity

21 January 2018

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Switching leukemia cell phenotype between life and death

21 January 2018

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Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines

21 January 2018

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Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor beta 1, and recombinant tumor necrosis factor alpha, in normal and neoplastic cells

21 January 2018

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Signalling pathways of the TNF superfamily: a double-edged sword

21 January 2018

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Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation

21 January 2018

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Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences

21 January 2018

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The paradox of pro-inflammatory cytokines in cancer

21 January 2018

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Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling

21 January 2018

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Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase

21 January 2018

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Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells

21 January 2018

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Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells

21 January 2018

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UVB-induced IL-18 production in human keratinocyte cell line NCTC 2544 through NF-kappaB activation

21 January 2018

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Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

21 January 2018

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Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia

21 January 2018

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Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets

21 January 2018

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Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.

21 January 2018

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Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.

21 January 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

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Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

21 January 2018

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Signal transduction pathways: targets for chemoprevention of skin cancer

21 January 2018

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Mitogen-activated protein kinase activation in UV-induced signal transduction

21 January 2018

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

21 January 2018

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Curcumin attenuates DNB-induced murine colitis.

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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TOR signaling in growth and metabolism

21 January 2018

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Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells

21 January 2018

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Curcumin disrupts the Mammalian target of rapamycin-raptor complex.

21 January 2018

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Cyclooxygenase 2: a molecular target for cancer prevention and treatment

21 January 2018

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Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase

21 January 2018

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Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells

21 January 2018

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The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

21 January 2018

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Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice

21 January 2018

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In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties

21 January 2018

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Inhibitory activity of diarylheptanoids on farnesyl protein transferase

21 January 2018

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Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells

21 January 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

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Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

21 January 2018

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Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.

21 January 2018

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Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells

21 January 2018

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Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias

21 January 2018

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Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells

21 January 2018

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Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model

21 January 2018

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Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells

21 January 2018

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Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines

21 January 2018

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

21 January 2018

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Cycling to cancer with cyclin D1

21 January 2018

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Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1.

21 January 2018

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Overexpression of cyclin D1 is rare in human prostate carcinoma

21 January 2018

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Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

21 January 2018

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Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells

21 January 2018

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Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

21 January 2018

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Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms

21 January 2018

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Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153".

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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p53 function and dysfunction

21 January 2018

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Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

21 January 2018

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Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction

21 January 2018

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Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.

21 January 2018

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Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells

21 January 2018

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Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids

21 January 2018

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In vitro and In silico studies on inhibitory effects of curcumin on multi drug resistance associated protein (MRP1) in retinoblastoma cells

21 January 2018

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Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research

21 January 2018

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Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

21 January 2018

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Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

21 January 2018

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Effect of curcumin on miRNA expression in human Y79 retinoblastoma cells.

21 January 2018

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Curcumin: updated molecular mechanisms and intervention targets in human lung cancer

21 January 2018

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Curcumin Modulates MicroRNA-203–Mediated Regulation of the Src-Akt Axis in Bladder Cancer

21 January 2018

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Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer.

21 January 2018

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Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF

21 January 2018

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Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

21 January 2018

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Cyclin D1 protein expression and function in human breast cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.1041

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27 August 2017

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