Challenges in T cell receptor gene therapy. (Q38011650)

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1 February 2020

title

Challenges in T cell receptor gene therapy (English)

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1 February 2020

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3

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1 February 2020

author name string

Benjamin J Uttenthal

series ordinal

1

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1 February 2020

Ignatius Chua

series ordinal

2

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1 February 2020

Hans J Stauss

series ordinal

4

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publication date

1 June 2012

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1 February 2020

published in

Journal of Gene Medicine

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volume

14

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issue

6

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1 February 2020

page(s)

386-399

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1 February 2020

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Selected murine residues endow human TCR with enhanced tumor recognition

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Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells

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Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

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Requirements for effective antitumor responses of TCR transduced T cells

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Recombinant AAV vectors containing the foot and mouth disease virus 2A sequence confer efficient bicistronic gene expression in cultured cells and rat substantia nigra neurons

21 January 2018

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

21 January 2018

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CD3 limits the efficacy of TCR gene therapy in vivo

21 January 2018

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Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR.

21 January 2018

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Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

21 January 2018

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Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

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Monoclonal T-cell receptors: new reagents for cancer therapy.

21 January 2018

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Targeting p53 as a general tumor antigen

21 January 2018

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Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.

21 January 2018

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Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells

21 January 2018

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

21 January 2018

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Transgenic mice with a diverse human T cell antigen receptor repertoire.

21 January 2018

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Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules

21 January 2018

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Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: reagents for tumor immunotherapy

21 January 2018

1 reference

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells

21 January 2018

1 reference

Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen

21 January 2018

1 reference

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity

21 January 2018

1 reference

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors

21 January 2018

1 reference

Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.

21 January 2018

1 reference

Allo-HLA-reactive T cells inducing graft-versus-host disease are single peptide specific

21 January 2018

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Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction

21 January 2018

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Display, engineering, and applications of antigen-specific T cell receptors

21 January 2018

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High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.

21 January 2018

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Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.

21 January 2018

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In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 January 2018

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Selection of functional T cell receptor mutants from a yeast surface-display library

21 January 2018

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

21 January 2018

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Rational design of T cell receptors with enhanced sensitivity for antigen

21 January 2018

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Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.

21 January 2018

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CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.

21 January 2018

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Directed evolution of human T-cell receptors with picomolar affinities by phage display

21 January 2018

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

21 January 2018

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Changing T cell specificity by retroviral T cell receptor display

21 January 2018

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Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

21 January 2018

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

21 January 2018

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TCRs with high affinity for foreign pMHC show self-reactivity

21 January 2018

1 reference

Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

21 January 2018

1 reference

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain

21 January 2018

1 reference

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

21 January 2018

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Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha

21 January 2018

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Generation of T cell help through a MHC class I-restricted TCR.

21 January 2018

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CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model

21 January 2018

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A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection

21 January 2018

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Differentiation of effector CD4 T cell populations (*)

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MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro

21 January 2018

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Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells

21 January 2018

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Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.

21 January 2018

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Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

21 January 2018

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Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

21 January 2018

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Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.

21 January 2018

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Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

21 January 2018

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Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor.

21 January 2018

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Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

21 January 2018

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Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

21 January 2018

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A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

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Long-term functionality of TCR-transduced T cells in vivo.

21 January 2018

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Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

21 January 2018

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CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo

21 January 2018

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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

21 January 2018

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Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

21 January 2018

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Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

21 January 2018

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High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

21 January 2018

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Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.

21 January 2018

1 reference

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

21 January 2018

1 reference

Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.

21 January 2018

1 reference

Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.

21 January 2018

1 reference

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

21 January 2018

1 reference

Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer

21 January 2018

1 reference

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

21 January 2018

1 reference

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

21 January 2018

1 reference

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

21 January 2018

1 reference

A human memory T cell subset with stem cell-like properties

21 January 2018

1 reference

Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination

21 January 2018

1 reference

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

21 January 2018

1 reference

mTOR regulates memory CD8 T-cell differentiation

21 January 2018

1 reference

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity

21 January 2018

1 reference

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

21 January 2018

1 reference

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

21 January 2018

1 reference

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

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HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia

21 January 2018

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Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors

21 January 2018

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Tumor cells escape suicide gene therapy by genetic and epigenetic instability

21 January 2018

1 reference

Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies

21 January 2018

1 reference

Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease.

21 January 2018

1 reference

Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

21 January 2018

1 reference

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

21 January 2018

1 reference

Improved artificial death switches based on caspases and FADD.

21 January 2018

1 reference

Controlling Signal Transduction with Synthetic Ligands

21 January 2018

1 reference

Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model.

21 January 2018

1 reference

Enhanced T cell receptor gene therapy for cancer

21 January 2018

1 reference

Inducible apoptosis as a safety switch for adoptive cell therapy

21 January 2018

1 reference

Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy

21 January 2018

1 reference

Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1

21 January 2018

1 reference

Transfer of Her-2/neu specificity into cytokine-induced killer (CIK) cells with RNA encoding chimeric immune receptor (CIR).

21 January 2018

1 reference

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

21 January 2018

1 reference

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

21 January 2018

1 reference

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

21 January 2018

1 reference

CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

21 January 2018

1 reference

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

21 January 2018

1 reference

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

21 January 2018

1 reference