Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease? (Q37985671)

26 August 2017

title

Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease? (English)

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26 August 2017

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Zhiyou Cai

1

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26 August 2017

Bin Zhao

2

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26 August 2017

Keshen Li

3

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26 August 2017

Liangqing Zhang

4

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26 August 2017

Chunhua Li

5

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26 August 2017

Sohel H Quazi

6

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26 August 2017

Yan Tan

7

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26 August 2017

publication date

16 February 2012

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Journal of Neuroscience Research

26 August 2017

published in

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26 August 2017

volume

90

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26 August 2017

issue

6

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26 August 2017

page(s)

1105-1118

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Autophagy in yeast: mechanistic insights and physiological function

26 August 2017

cites work

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A caspase cleaved form of tau is preferentially degraded through the autophagy pathway

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Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

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mTOR-what does it do?

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Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

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mTOR's role in ageing: protein synthesis or autophagy?

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Autophagy and Neurodegeneration

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The role of mTOR inhibition in augmenting radiation induced autophagy

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Beclin 1 complex in autophagy and Alzheimer disease

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Regulation of amyloid precursor protein processing by the Beclin 1 complex

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Immune regulation by rapamycin: moving beyond T cells

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Systems biology of the autophagy-lysosomal pathway

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Selective autophagy mediated by autophagic adapter proteins

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mTOR regulation of autophagy

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Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

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Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells

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Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A in AD models

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Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

21 January 2018

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Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Physiological significance of selective degradation of p62 by autophagy

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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DAP1, a novel substrate of mTOR, negatively regulates autophagy

21 January 2018

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Ordered organelle degradation during starvation-induced autophagy

21 January 2018

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Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

21 January 2018

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mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

21 January 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

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Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

21 January 2018

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

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A central role for autophagy in Alzheimer-type neurodegeneration

21 January 2018

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Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

21 January 2018

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Vesicular trafficking and autophagosome formation

21 January 2018

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Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease

21 January 2018

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Mechanisms of chaperone-mediated autophagy

21 January 2018

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Variations in the effects on synthesis of amyloid beta protein in modulated autophagic conditions

21 January 2018

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BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis

21 January 2018

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Chaperone-mediated autophagy in aging and disease

21 January 2018

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The role of autophagy in age-related neurodegeneration

21 January 2018

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Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

21 January 2018

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Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases

21 January 2018

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Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

21 January 2018

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Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E.

21 January 2018

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A(beta) generation in autophagic vacuoles

21 January 2018

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Autophagy: process and function

21 January 2018

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Physiological functions of autophagy

21 January 2018

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PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

21 January 2018

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Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity: role of p53, Redd1 and TSC2.

21 January 2018

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Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

21 January 2018

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Accumulation of tau in autophagic vacuoles in chloroquine myopathy

21 January 2018

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Tau expression in denervated rat muscles

21 January 2018

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Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner

21 January 2018

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Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.

21 January 2018

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Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

21 January 2018

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Autophagy in neurodegenerative disease: friend, foe or turncoat?

21 January 2018

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Autophagy, amyloidogenesis and Alzheimer disease

21 January 2018

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Delivery of cytoplasmic proteins to autophagosomes

21 January 2018

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Autophagy impairment stimulates PS1 expression and gamma-secretase activity

21 January 2018

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Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease

21 January 2018

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Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

21 January 2018

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mTOR-dependent signalling in Alzheimer's disease

21 January 2018

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The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice

21 January 2018

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Activation of mammalian target of rapamycin signaling in spatial learning

21 January 2018

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ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

21 January 2018

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

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Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

21 January 2018

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Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?

21 January 2018

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Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

21 January 2018

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

21 January 2018

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Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.

21 January 2018

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mTOR regulates autophagy-associated genes downstream of p73.

21 January 2018

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The mTOR pathway and its role in human genetic diseases

21 January 2018

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Dyneins, autophagy, aggregation and neurodegeneration

21 January 2018

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Chasing the elusive mammalian microautophagy

21 January 2018

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Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease

21 January 2018

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Tau as a biomarker of neurodegenerative diseases.

21 January 2018

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The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy.

21 January 2018

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AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

21 January 2018

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Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

21 January 2018

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Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

21 January 2018

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Tau protein pathology in neurodegenerative diseases

21 January 2018

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

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The TOR pathway comes of age

21 January 2018

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Apomorphine and Alzheimer Aβ: Roles for regulated α cleavage, autophagy, and antioxidation?

21 January 2018

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Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells

21 January 2018

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Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites

21 January 2018

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Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

21 January 2018

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Adaptive autophagy in Alexander disease-affected astrocytes

21 January 2018

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Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease.

21 January 2018

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A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway

21 January 2018

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Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

21 January 2018

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Autophagy: principles and significance in health and disease

21 January 2018

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Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

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Targeting mammalian target of rapamycin (mTOR) for health and diseases.

21 January 2018

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Parkin ubiquitinates and promotes the degradation of RanBP2

21 January 2018

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Autophagy and neurodegeneration

21 January 2018

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Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

21 January 2018

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AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

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Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

21 January 2018

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The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

21 January 2018

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

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Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

21 January 2018

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Enhancement of autophagy during lytic replication by the Kaposi's sarcoma-associated herpesvirus replication and transcription activator

21 January 2018

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

21 January 2018

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Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

21 January 2018

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Amelioration of protein misfolding disease by rapamycin: translation or autophagy?

21 January 2018

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

21 January 2018

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Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

21 January 2018

1 reference

Eaten alive: a history of macroautophagy

21 January 2018

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Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease

21 January 2018

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Autophagy mediates the mitotic senescence transition

21 January 2018

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Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease

21 January 2018

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Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

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Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain

21 January 2018

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Rapamycin promotes beta-amyloid production via ADAM-10 inhibition

21 January 2018

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APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells.

21 January 2018

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Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.23011

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26 August 2017

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