The TOR pathway comes of age (Q24568353)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19539012%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

review article

1 reference

title

The TOR pathway comes of age (English)

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31 January 2020

3

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31 January 2020

Brian K Kennedy

series ordinal

4

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31 January 2020

author name string

Monique N Stanfel

series ordinal

1

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31 January 2020

Lara S Shamieh

series ordinal

2

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31 January 2020

language of work or name

English

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publication date

16 June 2009

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Biochimica et Biophysica Acta

31 January 2020

published in

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31 January 2020

volume

1790

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31 January 2020

issue

10

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31 January 2020

page(s)

1067-1074

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Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

31 January 2020

cites work

1 reference

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Extension of chronological life span in yeast by decreased TOR pathway signaling

24 March 2017

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

24 March 2017

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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24 March 2017

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24 March 2017

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Regulation of longevity and stress resistance by Sch9 in yeast

24 March 2017

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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

24 March 2017

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TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae

24 March 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

24 March 2017

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An Aging Interventions Testing Program: study design and interim report

24 March 2017

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

24 March 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

24 March 2017

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24 March 2017

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

24 March 2017

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An expanding role for mTOR in cancer

24 March 2017

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Overview of caloric restriction and ageing

24 March 2017

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

24 March 2017

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

24 March 2017

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

24 March 2017

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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

24 March 2017

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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24 March 2017

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7 April 2017

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Genetics: influence of TOR kinase on lifespan in C. elegans

7 April 2017

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7 April 2017

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Extended longevity in mice lacking the insulin receptor in adipose tissue

7 April 2017

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

7 April 2017

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7 April 2017

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mTOR in growth and protection of hypertrophying myocardium

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

27 September 2017

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27 September 2017

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Replicative aging in yeast: the means to the end

27 September 2017

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27 September 2017

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27 September 2017

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Diabetes in Africa: epidemiology, management and healthcare challenges

27 September 2017

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Overview of human obesity and central mechanisms regulating energy homeostasis

27 September 2017

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The mTOR signaling network: insights from its role during embryonic development

27 September 2017

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Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span

27 September 2017

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Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer

27 September 2017

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Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

27 September 2017

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The epidemiology of obesity: the size of the problem

27 September 2017

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Evolutionary origins of obesity

27 September 2017

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Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders

27 September 2017

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Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

27 September 2017

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Eat less, live longer? New insights into the role of caloric restriction in the brain

27 September 2017

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Sirolimus in renal transplantation

27 September 2017

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Lifespan regulation by evolutionarily conserved genes essential for viability

27 September 2017

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Ruminations on dietary restriction and aging.

27 September 2017

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Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice

27 September 2017

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

27 September 2017

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Is dietary restriction beneficial for human health, such as for immune function?

27 September 2017

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

27 September 2017

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Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

27 September 2017

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The TOR signalling network from yeast to man.

27 September 2017

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Drosophila Melted modulates FOXO and TOR activity.

27 September 2017

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Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

27 September 2017

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Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy

27 September 2017

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Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

27 September 2017

1 reference

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The expanding TOR signaling network

27 September 2017

1 reference

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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

27 September 2017

1 reference

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regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis

27 September 2017

1 reference

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Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans

27 September 2017

1 reference

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Hypertrophy of the heart: a new therapeutic target?

27 September 2017

1 reference

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Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

27 September 2017

1 reference

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Yeast TOR Signaling: A Mechanism for Metabolic Regulation

27 September 2017

1 reference

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Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells

27 September 2017

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From instinct to intellect: the challenge of maintaining healthy weight in the modern world

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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New developments in the neurobiology of the tuberous sclerosis complex

27 September 2017

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27 September 2017

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27 September 2017

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Regulation of adipocyte differentiation and insulin action with rapamycin.

30 May 2018

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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

30 May 2018

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Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes

30 May 2018

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Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

30 May 2018

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FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

30 May 2018

1 reference

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Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies

30 May 2018

1 reference

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Autophagy is required for dietary restriction-mediated life span extension in C. elegans

28 November 2018

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

28 November 2018

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Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

28 November 2018

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TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

28 November 2018

1 reference

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Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

28 November 2018

1 reference

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Randomized, double-blind, placebo-controlled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial

28 November 2018

1 reference

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

28 November 2018

1 reference

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Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

28 November 2018

1 reference

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Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma

28 November 2018

1 reference

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Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span

28 November 2018

1 reference

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Rapamycin attenuates load-induced cardiac hypertrophy in mice

28 November 2018

1 reference

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A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

28 November 2018

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Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: role of 70-kDa S6 kinase and extracellular signal-regulated kinase

28 November 2018

1 reference

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Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes

28 November 2018

1 reference

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Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

28 November 2018

1 reference

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Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

28 November 2018

1 reference

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Low body temperature in long-lived Ames dwarf mice at rest and during stress.

28 November 2018

1 reference

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Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex

28 November 2018

1 reference

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Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

28 November 2018

1 reference

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Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis

28 November 2018

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12 December 2020

The chronological life span of Saccharomyces cerevisiae

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12 December 2020

Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy

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12 December 2020

Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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7 January 2021

The role of mTOR in the management of solid tumors: an overview

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7 January 2021

Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization

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7 January 2021

The multiple facets of mTOR in immunity.

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7 January 2021

Dietary energy restriction in breast cancer prevention

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Inhibition of corneal neovascularization by rapamycin

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7 January 2021

Tumours with PI3K activation are resistant to dietary restriction

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7 January 2021

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Caloric restriction and insulin-like growth factors in aging and cancer

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7 January 2021

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

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7 January 2021

MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

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Neovascular age-related macular degeneration: potential therapies.

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7 January 2021

Caloric restriction and cancer.

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Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19539012%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19539012%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

19539012

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19539012%20AND%20SRC:MED&resulttype=core&format=json