Causes and consequences of aneuploidy in cancer. (Q37978107)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Causes and consequences of aneuploidy in cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Benjamin Resio

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

David Pellman

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

language of work or name

1 reference

24 January 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

published in

Nature Reviews Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

189-203

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22269907%20AND%20SRC:MED&resulttype=core&format=json

The impact of translocations and gene fusions on cancer causation

21 January 2020

cites work

1 reference

Whole chromosome instability and cancer: a complex relationship

31 March 2020

1 reference

Multiple numerical chromosome aberrations in cancer: what are their causes and what are their consequences?

31 March 2020

1 reference

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

31 March 2020

1 reference

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

31 March 2020

1 reference

Chromosomes and cancer cells.

31 March 2020

1 reference

Mechanisms of chromosomal instability.

31 March 2020

1 reference

A little CIN may cost a lot: revisiting aneuploidy and cancer

31 March 2020

1 reference

The landscape of somatic copy-number alteration across human cancers

31 March 2020

1 reference

Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy

31 March 2020

1 reference

Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma

31 March 2020

1 reference

Trisomies 8 and 20 in desmoid tumors

31 March 2020

1 reference

Acute myeloid leukemia and myelodysplastic syndrome in children treated for cancer: comparison with primary presentation.

31 March 2020

1 reference

Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

31 March 2020

1 reference

Examining the link between chromosomal instability and aneuploidy in human cells

31 March 2020

1 reference

Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells

31 March 2020

1 reference

31 March 2020

Mechanisms of aneuploidy

1 reference

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

31 March 2020

1 reference

Merotelic kinetochore attachment: causes and effects.

31 March 2020

1 reference

A mechanism linking extra centrosomes to chromosomal instability

31 March 2020

1 reference

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

31 March 2020

1 reference

Deviant kinetochore microtubule dynamics underlie chromosomal instability.

31 March 2020

1 reference

Condensin association with histone H2A shapes mitotic chromosomes

31 March 2020

1 reference

The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments

31 March 2020

1 reference

Genome stability is ensured by temporal control of kinetochore-microtubule dynamics

31 March 2020

1 reference

Origins and consequences of centrosome aberrations in human cancers

31 March 2020

1 reference

Centrosome aberrations: cause or consequence of cancer progression?

31 March 2020

1 reference

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

31 March 2020

1 reference

Managing the centrosome numbers game: from chaos to stability in cancer cell division

31 March 2020

1 reference

Mitosis in a cell with multiple centrioles

31 March 2020

1 reference

Genetic instability in colorectal cancers

31 March 2020

1 reference

The significance of unstable chromosomes in colorectal cancer.

31 March 2020

1 reference

Characterization of MAD2B and other mitotic spindle checkpoint genes

31 March 2020

1 reference

Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.

31 March 2020

1 reference

Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.

31 March 2020

1 reference

On the road to cancer: aneuploidy and the mitotic checkpoint

31 March 2020

1 reference

Three classes of genes mutated in colorectal cancers with chromosomal instability

31 March 2020

1 reference

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

31 March 2020

1 reference

Aneuploid colon cancer cells have a robust spindle checkpoint

31 March 2020

1 reference

Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes.

31 March 2020

1 reference

Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells

31 March 2020

1 reference

The spindle-assembly checkpoint in space and time

31 March 2020

1 reference

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

31 March 2020

1 reference

Mutational inactivation of STAG2 causes aneuploidy in human cancer

31 March 2020

1 reference

Cohesin: genomic insights into controlling gene transcription and development

31 March 2020

1 reference

Aneuploidy: cells losing their balance

31 March 2020

1 reference

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

31 March 2020

1 reference

Aneuploidy drives genomic instability in yeast

31 March 2020

1 reference

Growth arrest and chromosome instability in aneuploid yeast.

31 March 2020

1 reference

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

31 March 2020

1 reference

Population-based analyses of mortality in trisomy 13 and trisomy 18.

31 March 2020

1 reference

Studies on Down's syndrome in tissue culture. I. Growth rates and protein contents of fibroblast cultures

31 March 2020

1 reference

Cell Selection in vivo in Normal/G Trisomic Mosaics

31 March 2020

1 reference

Aneuploidy and confined chromosomal mosaicism in the developing human brain.

31 March 2020

1 reference

The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study.

31 March 2020

1 reference

Genomic expression programs in the response of yeast cells to environmental changes

31 March 2020

1 reference

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

31 March 2020

1 reference

The cellular level of yeast ribosomal protein L25 is controlled principally by rapid degradation of excess protein

31 March 2020

1 reference

The accumulation of three yeast ribosomal proteins under conditions of excess mRNA is determined primarily by fast protein decay

31 March 2020

1 reference

Identification of aneuploidy-tolerating mutations

31 March 2020

1 reference

Comparison of stable-isotope labeling with amino acids in cell culture and spectral counting for relative quantification of protein expression.

31 March 2020

1 reference

Direct comparison of stable isotope labeling by amino acids in cell culture and spectral counting for quantitative proteomics.

31 March 2020

1 reference

Meiotic chromosome segregation in triploid strains of Saccharomyces cerevisiae

31 March 2020

1 reference

Genome-wide genetic analysis of polyploidy in yeast

31 March 2020

1 reference

Tetraploidy, aneuploidy and cancer

31 March 2020

1 reference

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

31 March 2020

1 reference

The impact of p53 and p73 on aneuploidy and cancer

31 March 2020

1 reference

Aneuploid neurons are functionally active and integrated into brain circuitry

31 March 2020

1 reference

Chromosomal variation in neurons of the developing and adult mammalian nervous system

31 March 2020

1 reference

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

31 March 2020

1 reference

ATM Activation by Oxidative Stress

31 March 2020

1 reference

Aneuploidy acts both oncogenically and as a tumor suppressor

31 March 2020

1 reference

The role of aneuploidy in promoting and suppressing tumors

31 March 2020

1 reference

The aneuploidy paradox in cell growth and tumorigenesis

31 March 2020

1 reference

Loss of pRB causes centromere dysfunction and chromosomal instability

31 March 2020

1 reference

Retinoblastoma tumor suppressor and genome stability

31 March 2020

1 reference

pRB, a tumor suppressor with a stabilizing presence

31 March 2020

1 reference

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive

31 March 2020

1 reference

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

31 March 2020

1 reference

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

31 March 2020

1 reference

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

31 March 2020

1 reference

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer

31 March 2020

1 reference

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor

31 March 2020

1 reference

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors

31 March 2020

1 reference

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

31 March 2020

1 reference

Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours

31 March 2020

1 reference

Trisomy 4 Leading to Duplication of a Mutated KIT Allele in Acute Myeloid Leukemia with Mast Cell Involvement

31 March 2020

1 reference

AML with t(8;21) and trisomy 4: possible involvement of c-kit?

31 March 2020

1 reference

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

31 March 2020

1 reference

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

31 March 2020

1 reference

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

31 March 2020

1 reference

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

31 March 2020

1 reference

Revealing hidden relationships among yeast genes involved in chromosome segregation using systematic synthetic lethal and synthetic dosage lethal screens

31 March 2020

1 reference

Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation

31 March 2020

1 reference

Polyploids require Bik1 for kinetochore-microtubule attachment

31 March 2020

1 reference

Centrosome clustering and chromosomal (in)stability: A matter of life and death

31 March 2020

1 reference

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

31 March 2020

1 reference

Identification of aneuploidy-selective antiproliferation compounds

31 March 2020

1 reference

Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

31 March 2020

1 reference

Outcome according to cytogenetic abnormalities and DNA ploidy in myeloma patients receiving short induction with weekly bortezomib followed by maintenance

31 March 2020

1 reference

17 AAG for HSP90 inhibition in cancer--from bench to bedside

31 March 2020

1 reference

Down syndrome, drug metabolism and chromosome 21.

31 March 2020

1 reference

The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.

31 March 2020

1 reference

Microcell-mediated chromosome transfer (MMCT): small cells with huge potential

31 March 2020

1 reference

Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells

31 March 2020

1 reference

Widespread aneuploidy revealed by DNA microarray expression profiling.

31 March 2020

1 reference

Aneuploidy and isochromosome formation in drug-resistant Candida albicans

31 March 2020

1 reference

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.

31 March 2020

1 reference

Aneuploidy and cancer: from correlation to causation

31 March 2020

1 reference

Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8.

31 March 2020

1 reference

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

31 March 2020

1 reference

Merotelic kinetochore orientation, aneuploidy, and cancer.

31 March 2020

1 reference

12 December 2020

Targeted inactivation of p53 in human cells does not result in aneuploidy

1 reference

12 December 2020

Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation

1 reference

12 December 2020

Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas

1 reference

12 December 2020

Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy

1 reference

12 December 2020

Morphologic, immunologic, and cytogenetic classification of acute myeloid leukemia and myelodysplastic syndrome in childhood: a report from the Childrens Cancer Group

1 reference

12 December 2020

Role of the retinoblastoma tumor suppressor in the maintenance of genome integrity

1 reference

12 December 2020

How aneuploidy may cause cancer and genetic instability

1 reference

12 December 2020

Centrosome defects and genetic instability in malignant tumors

1 reference

12 December 2020